Zobrazeno 1 - 10
of 453
pro vyhledávání: '"Nigel W. Bunnett"'
Autor:
Ashlee Caldwell, Luke Grundy, Andrea M. Harrington, Sonia Garcia-Caraballo, Joel Castro, Nigel W. Bunnett, Stuart M. Brierley
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-19 (2022)
Abstract The mechanisms underlying chronic bladder conditions such as interstitial cystitis/bladder pain syndrome (IC/BPS) and overactive bladder syndrome (OAB) are incompletely understood. However, targeting specific receptors mediating neuronal sen
Externí odkaz:
https://doaj.org/article/e6c2108661e44edea86c27c271ba7cfa
Autor:
Nicole N. Scheff, Ian M. Wall, Sam Nicholson, Hannah Williams, Elyssa Chen, Nguyen H. Tu, John C. Dolan, Cheng Z. Liu, Malvin N. Janal, Nigel W. Bunnett, Brian L. Schmidt
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Oral cancer patients report sensitivity to spicy foods and liquids. The mechanism responsible for chemosensitivity induced by oral cancer is not known. We simulate oral cancer-induced chemosensitivity in a xenograft oral cancer mouse model u
Externí odkaz:
https://doaj.org/article/18f2ffcae6f84a02abb412b9786e83d1
Autor:
Francesco De Logu, Romina Nassini, Alan Hegron, Lorenzo Landini, Dane D. Jensen, Rocco Latorre, Julia Ding, Matilde Marini, Daniel Souza Monteiro de Araujo, Paulina Ramírez-Garcia, Michael Whittaker, Jeffri Retamal, Mustafa Titiz, Alessandro Innocenti, Thomas P. Davis, Nicholas Veldhuis, Brian L. Schmidt, Nigel W. Bunnett, Pierangelo Geppetti
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
The mechanism of CGRP-evoked peripheral pain is unclear. Here, the authors show that the CGRP-mediated neuronal/Schwann cell pathway mediates allodynia associated with neurogenic inflammation, contributing to the algesic action of CGRP in mice.
Externí odkaz:
https://doaj.org/article/279bcfd8279341c7ae1422cec3fc2183
Autor:
Nguyen Huu Tu, Kenji Inoue, Parker K. Lewis, Ammar Khan, Jun Hyeong Hwang, Varun Chokshi, Branka Brukner Dabovic, Shanmugapriya Selvaraj, Aditi Bhattacharya, Zinaida Dubeykovskaya, Nathalie M. Pinkerton, Nigel W. Bunnett, Cynthia A. Loomis, Donna G. Albertson, Brian L. Schmidt
Publikováno v:
Cells, Vol 12, Iss 13, p 1675 (2023)
Oral cancer patients suffer pain at the site of the cancer. Calcitonin gene related polypeptide (CGRP), a neuropeptide expressed by a subset of primary afferent neurons, promotes oral cancer growth. CGRP also mediates trigeminal pain (migraine) and n
Externí odkaz:
https://doaj.org/article/4ad97754b9c84ef08dfb3e97512427c3
Autor:
Francesco De Logu, Romina Nassini, Serena Materazzi, Muryel Carvalho Gonçalves, Daniele Nosi, Duccio Rossi Degl’Innocenti, Ilaria M. Marone, Juliano Ferreira, Simone Li Puma, Silvia Benemei, Gabriela Trevisan, Daniel Souza Monteiro de Araújo, Riccardo Patacchini, Nigel W. Bunnett, Pierangelo Geppetti
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
Following peripheral nerve injury, influx of immune cells to the site may contribute to the development of chronic pain. Here the authors show that TRPA1 is expressed on Schwann cells and contributes to immune cell influx in a mouse model of neuropat
Externí odkaz:
https://doaj.org/article/cc21242beb744e37aeabdb35c1c9899c
Autor:
Maria Roitman, Laura E. Edgington-Mitchell, Jon Mangum, James Ziogas, Alexios A. Adamides, Paul Myles, Hearan Choo-Bunnett, Nigel W. Bunnett, Jenny M. Gunnersen
Publikováno v:
PAIN Reports, Vol 4, Iss 2, p e719 (2019)
Abstract. Introduction:. Seizure-related protein 6 (Sez6) contributes to chronic pain development as sez6 knockout mice show attenuated pain behaviours after peripheral nerve injury, compared with control mice. The type I transmembrane isoform of Sez
Externí odkaz:
https://doaj.org/article/ea892000455c4cb09635c7b83052428c
Publikováno v:
Frontiers in Endocrinology, Vol 5 (2015)
Externí odkaz:
https://doaj.org/article/575fd773d831463abba33e6ba328ff2c
Publikováno v:
Physiological reviews. 103(1)
Proteases are signaling molecules that specifically control cellular functions by cleaving protease-activated receptors (PARs). The four known PARs are members of the large family of G protein-coupled receptors. These transmembrane receptors control
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::271d6d12f5e8233913f3b2a8e603cc4e
https://pubmed.ncbi.nlm.nih.gov/35901239
https://pubmed.ncbi.nlm.nih.gov/35901239
Autor:
Schmidt, Nguyen Huu Tu, Kenji Inoue, Parker K. Lewis, Ammar Khan, Jun Hyeong Hwang, Varun Chokshi, Branka Brukner Dabovic, Shanmugapriya Selvaraj, Aditi Bhattacharya, Zinaida Dubeykovskaya, Nathalie M. Pinkerton, Nigel W. Bunnett, Cynthia A. Loomis, Donna G. Albertson, Brian L.
Publikováno v:
Cells; Volume 12; Issue 13; Pages: 1675
Oral cancer patients suffer pain at the site of the cancer. Calcitonin gene related polypeptide (CGRP), a neuropeptide expressed by a subset of primary afferent neurons, promotes oral cancer growth. CGRP also mediates trigeminal pain (migraine) and n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::5fd6f735c35c806ccf80e59c80061016
Autor:
Alan Hegron, Chloe J. Peach, Raquel Tonello, Philipp Seemann, Shavonne Teng, Rocco Latorre, Harald Huebner, Dorothee Weikert, Jeanette Rientjes, Nicholas A. Veldhuis, Daniel P. Poole, Dane D. Jensen, Alex R. B. Thomsen, Brian L. Schmidt, Wendy L. Imlach, Peter Gmeiner, Nigel W. Bunnett
Publikováno v:
Proceedings of the National Academy of Sciences. 120
The hypothesis that sustained G protein-coupled receptor (GPCR) signaling from endosomes mediates pain is based on studies with endocytosis inhibitors and lipid-conjugated or nanoparticle-encapsulated antagonists targeted to endosomes. GPCR antagonis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc8246a969b2b8c49fad75dacbbedbf6
https://doi.org/10.1073/pnas.2220979120
https://doi.org/10.1073/pnas.2220979120