Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Nigel St John"'
Publikováno v:
Smart Materials and Structures. 31:015025
Fibre reinforced composites materials offer a pathway to produce passive shape adaptive smart marine propellers, which have improved performance characteristics over traditional metallic alloys. Automated fibre placement (AFP) technology can provide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d43e631d1367bcbde5bd98d9231f00c
https://doi.org/10.1088/1361-665x/ac3b21
https://doi.org/10.1088/1361-665x/ac3b21
Autor:
Manudha T. Herath, Nigel St John, Paul A. Brandner, Gangadhara B Prusty, Bryce W. Pearce, Andrew W. Phillips
Publikováno v:
Marine Structures. 80:103084
The primary objective of this paper is to present cavitation tunnel tests performed on an optimised shape-adaptive composite hydrofoil and compare the results to other composite hydrofoils. The optimised composite hydrofoil was designed based on prio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd99db2370b2aa3498a217b02aa59a7a
https://doi.org/10.1016/j.marstruc.2021.103084
https://doi.org/10.1016/j.marstruc.2021.103084
Publikováno v:
Composite Structures. 176:359-378
This paper presents a novel optimisation scheme using a Genetic Algorithm (GA) to produce a shape-adaptable composite hydrofoil. Importantly the scheme included additional constraints that ensure that the hydrofoils produced were able to be manufactu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2398e5f8bd967cea233c901aad68e60c
https://doi.org/10.1016/j.compstruct.2017.05.012
https://doi.org/10.1016/j.compstruct.2017.05.012
Publikováno v:
Composite Structures. 255:112961
The propulsive efficiency of a shape adaptive composite propeller increases with passive pitch (twist) change under a hydrodynamic load. These adaptive marine propellers are usually designed using straight fibre tows to obtain optimised layup with su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::521cf8ffc7302198a73b7a2322626aed
https://doi.org/10.1016/j.compstruct.2020.112961
https://doi.org/10.1016/j.compstruct.2020.112961
Autor:
Dan Shi, Moore Nigel St John, Donald B. Konopacki, Kelly J. Larson, Gary Gintant, Kathy K. Sarris, Peter F. Bousquet, Sean C. Turner, Peng Zhang, Ayome Abibi, Christopher M. Harris, Tegest Kebede, Xiubo Tang, Adrian D. Hobson, John W. Maull, Elizabeth Louise van der Kam, Ana L. Aguirre, Youngjae Kim, Anurupa Shrestha
Publikováno v:
Journal of Medicinal Chemistry. 58:9154-9170
S1P5 is one of 5 receptors for sphingosine-1-phosphate and is highly expressed on endothelial cells within the blood-brain barrier, where it maintains barrier integrity in in vitro models (J. Neuroinflamm. 2012, 9, 133). Little more is known about th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e55edd033a09d0a8757996d1588c7cf
https://doi.org/10.1021/acs.jmedchem.5b00928
https://doi.org/10.1021/acs.jmedchem.5b00928
Publikováno v:
Computer Methods in Applied Mechanics and Engineering. 284:835-860
This paper presents a layup optimisation algorithm for composite marine propellers, including the hygrothermal effects, using Non-Uniform Rational B-Splines (NURBS) based FEM coupled with real-coded Genetic Algorithm (GA). The use of Iso-Geometric An
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b85130430461e9855a25cdf88a1bd7dd
https://doi.org/10.1016/j.cma.2014.10.028
https://doi.org/10.1016/j.cma.2014.10.028
An optimization scheme using the Cell-based Smoothed Finite Element Method (CS-FEM) combined with a Genetic Algorithm (GA) framework is proposed in this paper to design shape adaptive laminated composite marine propellers. The proposed scheme utilize
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::807b5665bf087de6ce13b34e3658c0a9
http://arxiv.org/abs/1310.4617
http://arxiv.org/abs/1310.4617
Autor:
Valerie L. Pivorunas, Douglas Marcotte, Andrew Burchat, Maria A. Argiriadi, Eric R. Goedken, David Banach, Woller Kevin R, Ramkrishna Sadhukhan, Lu Wang, Neil Wishart, Gary Overmeyer, Robert V. Talanian, Dixon Richard W, Medha J. Tomlinson, Jeffrey W. Voss, David W. Borhani, Silvino Sousa, Moore Nigel St John
Publikováno v:
BMC Structural Biology, Vol 12, Iss 1, p 22 (2012)
BMC Structural Biology
BMC Structural Biology
Background Structure-based drug design (SBDD) can accelerate inhibitor lead design and optimization, and efficient methods including protein purification, characterization, crystallization, and high-resolution diffraction are all needed for rapid, it
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d20a2fcfe03e8fdfd40a82f7a43bf999
http://www.biomedcentral.com/1472-6807/12/22
http://www.biomedcentral.com/1472-6807/12/22
Autor:
Nathan S. Josephsohn, John W. Maull, Moore Nigel St John, Brian Bettencourt, Morytko Michael J, Lu Wang, Edit Tarcsa, Jonathan George, Biqin Li, Paul Rafferty, Diana L. Donnelly-Roberts, Marian T. Namovic, Patrick Betschmann, Michael Friedman, Jose-Andres Salmeron-Garcia, Gavin C. Hirst, Donald Konopacki, Woller Kevin R
Publikováno v:
Bioorganicmedicinal chemistry letters. 18(14)
A novel series of cyanoguanidine-piperazine P2X(7) antagonists were identified and structure-activity relationship (SAR) studies described. Compounds were assayed for activity at human and rat P2X(7) receptors in addition to their ability to inhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ebdea569c3d25c50a55301e1139af93
https://pubmed.ncbi.nlm.nih.gov/18595695
https://pubmed.ncbi.nlm.nih.gov/18595695