Výsledky vyhledávání - "Nigel Silman"

Akademický článek

Temporal Expression of Peripheral Blood Leukocyte Biomarkers in a Macaca fascicularis Infection Model of Tuberculosis; Comparison with Human Datasets and Analysis with Parametric/Non-parametric Tools for Improved Diagnostic Biomarker Identification.

Autor: Sajid Javed, Leanne Marsay, Alice Wareham, Kuiama S Lewandowski, Ann Williams, Michael J Dennis, Sally Sharpe, Richard Vipond, Nigel Silman, Graham Ball, Karen E Kempsell

Publikováno v: PLoS ONE, Vol 11, Iss 5, p e0154320 (2016)

A temporal study of gene expression in peripheral blood leukocytes (PBLs) from a Mycobacterium tuberculosis primary, pulmonary challenge model Macaca fascicularis has been conducted. PBL samples were taken prior to challenge and at one, two, four and

Externí odkaz: https://doaj.org/article/ac8b5b308364458d806563b68366957d

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Real-time bacterial detection with an intracellular ROS sensing platform

Autor: Jacqueline M. Hicks, R. Halkerston, Frankie J. Rawson, Nigel Silman, Jonathan W. Aylott, Simon K. Jackson

Publikováno v: Biosensorsbioelectronics. 141

Reactive oxygen species are highly reactive molecules that as well as being ubiquitously expressed throughout the body, are also known to be involved in many diseases and disorders including bacterial infection. Current technology has limited success

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb4af42fcc0266b4c88145d1130a55e1
https://pubmed.ncbi.nlm.nih.gov/31299629

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Mass transport of lipopolysaccharide induced H2O2 detected by an intracellular carbon nanoelectrode sensor

Autor: Jacqueline Hicks, Frankie J. Rawson, Jonathan W. Aylott, Simon K. Jackson, Nigel Silman

Publikováno v: Bioelectrochemistry. 135:107547

Hydrogen peroxide is a key component of the innate immune response, regulating how a cell responds to a bacterial threat; however, being transient in nature makes it extremely difficult to detect. We show the development of an improved biosensor capa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::538a29368287b71b7fdf1d6843999036
https://doi.org/10.1016/j.bioelechem.2020.107547

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Development and Assessment of a Diagnostic DNA Oligonucleotide Microarray for Detection and Typing of Meningitis-Associated Bacterial Species

Autor: Sonal Shah, Peter Marsh, Stephen P Kidd, Michael J. Elmore, Andrew Telfer Brunton, Richard Vipond, Steve M. Green, Stephanie A Bannister, Anvy Thomas, Karen E. Kempsell, Elizabeth Kirby, Nigel Silman

Publikováno v: High-Throughput
Volume 7
Issue 4
High-Throughput, Vol 7, Iss 4, p 32 (2018)

Meningitis is commonly caused by infection with a variety of bacterial or viral pathogens. Acute bacterial meningitis (ABM) can cause severe disease, which can progress rapidly to a critical life-threatening condition. Rapid diagnosis of ABM is criti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a6bc93977b2337a702b7c49bb04b818

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Comparison of a novel microcrystalline tyrosine adjuvant with aluminium hydroxide for enhancing vaccination against seasonal influenza

Autor: Nicola Swan, Karen E. Gooch, C. Prevosto, Bassam Hallis, Murray A. Skinner, Nigel Silman, Anthony C. Marriott, Matthew D. Heath

Publikováno v: BMC Infectious Diseases, Vol 17, Iss 1, Pp 1-9 (2017)
BMC Infectious Diseases

Background Vaccination against seasonal influenza strains is recommended for “high risk” patient groups such as infants, elderly and those with respiratory or circulatory diseases. However, efficacy of the trivalent influenza vaccine (TIV) is poo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7e41683bf9da80af1a51be39bc45e87
https://doi.org/10.1186/s12879-017-2329-5

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Case study: design and implementation of training for scientists deploying to Ebola diagnostic field laboratories in Sierra Leone: October 2014 to February 2016

Autor: Sonal Shah, Nigel Silman, Tim Brooks, Suzanna Lewis, Amanda Semper, Jane Shallcross, Liz Evans, Christopher H. Logue, Jason Busuttil, Miles W. Carroll, Sara Fraser, Daniel Bailey, Amber Lansley, Clare Shieber

Publikováno v: Philosophical transactions of the Royal Society of London. Series B, Biological sciences. 372(1721)

As part of the UK response to the 2013–2016 Ebola virus disease (EVD) epidemic in West Africa, Public Health England (PHE) were tasked with establishing three field Ebola virus (EBOV) diagnostic laboratories in Sierra Leone by the UK Department for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cacbc2eb90f53dc9406209620fa1992
https://pubmed.ncbi.nlm.nih.gov/28396470

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Autor: Graham Ball, Mike Dennis, Sally Sharpe, Ann Williams, Sajid Javed, Richard Vipond, Nigel Silman, Alice Wareham, Kuiama S. Lewandowski, Leanne Marsay, Karen E. Kempsell

Publikováno v: PLoS ONE
PLoS ONE, Vol 11, Iss 5, p e0154320 (2016)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::898f98d695f45122046998c869172e70
http://europepmc.org/articles/PMC4882019

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Cellular immune response to human influenza viruses differs between H1N1 and H3N2 subtypes in the ferret lung

Autor: Anthony C. Marriott, Catherine J. Whittaker, Kathryn A. Ryan, Gillian S. Slack, Nigel Silman, Miles W. Carroll, Karen E. Gooch, Jennifer A. Kane

Publikováno v: PLoS ONE
PLoS ONE, Vol 13, Iss 9, p e0202675 (2018)

Seasonal influenza virus infections cause yearly epidemics which are the source of a significant public health burden worldwide. The ferret model for human influenza A virus (IAV) is widely used and has several advantages over other animal models suc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a9d9f6e2f61a8bb75d75bc0e7d96bd4
https://doi.org/10.1371/journal.pone.0202675

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