Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Nigel Ramsden"'
Autor:
Florio Dalla Vedova, Pierre Morin, Thibault Roux, Roberta Brombin, Alberto Piccinini, Nigel Ramsden
Publikováno v:
Aerospace, Vol 5, Iss 2, p 48 (2018)
The paper introduces and describes the recent and still ongoing development activities performed in Luxembourg for In-Orbit Attach Mechanisms for (Drag) Sails Modules to be operated from Space Tugs. After some preparatory work aiming at understanding
Externí odkaz:
https://doaj.org/article/b03ec04eb461468e94f508e9d000b7b9
Autor:
Sophie Weil, Daniel Domínguez Azorín, Erik Jung, Josie Higgins, Hafeez Mohammed, Jill Reckless, Nigel Ramsden, Peter Keller, David Grainger, Wolfgang Wick, Frank Winkler
Publikováno v:
Neuro-Oncology. 24:vii210-vii210
Glioblastomas are known to be highly therapy resistant tumors. The description of tumor microtubes (TMs) as long cellular protrusions that connect glioblastoma cells to a network resistant against all standard therapies advanced the basic biological
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::551a6de0e254b6c11b47dbd9123c893f
https://doi.org/10.1093/neuonc/noac209.806
https://doi.org/10.1093/neuonc/noac209.806
Autor:
Rab K. Prinjha, Anne Rueger, Neil Stuart Garton, Dirk Eberhard, David Matthew Wilson, Marcus Bantscheff, Robert J. Sheppard, Kevin Lee, Jack A. Brown, Nigel Ramsden, Susan Marie Westaway, Gerard Drewes, Philip G. Humphreys, Toby Mathieson, Gerard Joberty, Marcel Muelbaier, Valerie Reader, Markus Boesche
Publikováno v:
ACS Chemical Biology. 11:2002-2010
The 2-oxoglutarate-dependent dioxygenase target class comprises around 60 enzymes including several subfamilies with relevance to human disease, such as the prolyl hydroxylases and the Jumonji-type lysine demethylases. Current drug discovery approach
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1e514fee0ea43db13a3bff9292a026a
https://doi.org/10.1021/acschembio.6b00080
https://doi.org/10.1021/acschembio.6b00080
Autor:
Pierre Morin, Alberto Piccinini, Thibault Roux, Florio Dalla Vedova, Nigel Ramsden, Roberta Brombin
Publikováno v:
Aerospace
Aerospace, Vol 5, Iss 2, p 48 (2018)
Aerospace; Volume 5; Issue 2; Pages: 48
Aerospace, Vol 5, Iss 2, p 48 (2018)
Aerospace; Volume 5; Issue 2; Pages: 48
The paper introduces and describes the recent and still ongoing development activities performed in Luxembourg for In-Orbit Attach Mechanisms for (Drag) Sails Modules to be operated from Space Tugs. After some preparatory work aiming at understanding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::831dd8bda16bf73eedbc5fca073d036f
Autor:
Linda E. Fellows, Nigel Ramsden, Bryan Winchester, George W. J. Fleet, Robert J. Nash, A C Richardson, I. Cenci Di Bello
A series of epimers and deoxy derivatives of castanospermine has been synthesized to investigate the contribution of the different chiral centres to the specificity and potency of inhibition of human liver glycosidases. Castanospermine inhibits all f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7481e74174ba9cb70a17fee3ff72a2d
https://ora.ox.ac.uk/objects/uuid:d0f814f5-4729-47df-95d3-b78b04e29d1c
https://ora.ox.ac.uk/objects/uuid:d0f814f5-4729-47df-95d3-b78b04e29d1c
Short syntheses of D-deoxymannojirimycin and of D-mannonolactam from L-gulonolactone are reported; identical sequences on D-gulonolactone lead to L-deoxymannojirimycin and L-mannonolactam.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e2144ecdaa7922069fbcb7010e6e819
https://ora.ox.ac.uk/objects/uuid:f4fffed7-4326-4e87-b890-9d5f2ec62848
https://ora.ox.ac.uk/objects/uuid:f4fffed7-4326-4e87-b890-9d5f2ec62848
The efficient formation of a bicyclic oxazolidine by lithium aluminium hydride reduction of a tertiary amide provides an example of intramolecular nucleophilic capture of an iminium ion equivalent by the oxygen of a silyl ether.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e630d6e64807831d7c814efbaafff6ff
https://doi.org/10.1039/p29910001991
https://doi.org/10.1039/p29910001991
Reaction of 2- O -trifluoromethanesulphonate esters of 1,4- and 1,5-α-hydroxy lactones with lithium iodide trihydrate in tetrahydrofuran gives good to excellent yields of the corresponding 2-deoxy lactones.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfad634a851d68177791d179a8d083f5
https://doi.org/10.1016/s0040-4039(00)97471-9
https://doi.org/10.1016/s0040-4039(00)97471-9
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:4546-4549
Dual PI3Kγ/δ inhibitors have recently been shown to be suitable targets for inflammatory and respiratory diseases. In a recent study we described the discovery of selective PI3Kγ inhibitors based on a triazolopyridine scaffold. Herein, we describe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57cdb8d7c2c1418318280fb642d6f511
https://doi.org/10.1016/j.bmcl.2012.05.121
https://doi.org/10.1016/j.bmcl.2012.05.121