Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Nigel P. S. Crawford"'
Autor:
Jean M. Winter, Natasha L. Curry, Derek M. Gildea, Kendra A. Williams, Minnkyong Lee, Ying Hu, Nigel P. S. Crawford
Publikováno v:
BMC Genomics, Vol 19, Iss 1, Pp 1-16 (2018)
Abstract Background It is well known that development of prostate cancer (PC) can be attributed to somatic mutations of the genome, acquired within proto-oncogenes or tumor-suppressor genes. What is less well understood is how germline variation cont
Externí odkaz:
https://doaj.org/article/cc2a9841f5f646f29d5b05b7ef2950d6
Autor:
Theresa T. Pham, Allena J. Ji, Jyoti Sharma, Sebastiaan J.M. Gaemers, M. Judith Peterschmitt, Nigel P. S. Crawford
Publikováno v:
Clinical Pharmacology in Drug Development
Venglustat is a small‐molecule glucosylceramide synthase (GCS) inhibitor designed to reduce the production of glucosylceramide (GL‐1) and thus is expected to substantially reduce formation of glucosylceramide‐based glycosphingolipids. Because o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::860129f2f4e029ab551b1a78f4bfbf7d
https://doi.org/10.1002/cpdd.865
https://doi.org/10.1002/cpdd.865
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e61848 (2013)
Neuroendocrine (NE) differentiation has gained increased attention as a prostate cancer (PC) prognostic marker. The aim of this study is to determine whether host germline genetic variation influences tumor progression and metastasis in C57BL/6-Tg(TR
Externí odkaz:
https://doaj.org/article/98df94023eb24663a41da0fd4f7b9870
Autor:
Jude Alsarraj, Farhoud Faraji, Thomas R Geiger, Katherine R Mattaini, Mia Williams, Josephine Wu, Ngoc-Han Ha, Tyler Merlino, Renard C Walker, Allen D Bosley, Zhen Xiao, Thorkell Andresson, Dominic Esposito, Nicholas Smithers, Dave Lugo, Rab Prinjha, Anup Day, Nigel P S Crawford, Keiko Ozato, Kevin Gardner, Kent W Hunter
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e80746 (2013)
Recent studies suggest that BET inhibitors are effective anti-cancer therapeutics. Here we show that BET inhibitors are effective against murine primary mammary tumors, but not pulmonary metastases. BRD4, a target of BET inhibitors, encodes two isofo
Externí odkaz:
https://doaj.org/article/c2c9aa744b3a4146a566e38515814caa
Autor:
Eugen Mengel, Derralynn Hughes, Ana Jovanovic, Sebastiaan J.M. Gaemers, Jyoti Sharma, Tanya Fischer, Raphael Schiffmann, Nigel P. S. Crawford, Pascal Minini
Publikováno v:
Molecular Genetics and Metabolism. 126:S131
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::550df714d0b841d3ccd0c177995ab7b1
https://doi.org/10.1016/j.ymgme.2018.12.336
https://doi.org/10.1016/j.ymgme.2018.12.336
Publikováno v:
Discovery medicine. 5(30)
Extract: Metastasis, the spread of cancer throughout the body, remains the leading cause of cancer-related death despite decades of investigation and the efforts of thousands of doctors and scientists. Over the past thirty to forty years tremendous s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c866e7a31c4008640c6a844deb65f610
https://pubmed.ncbi.nlm.nih.gov/20704832
https://pubmed.ncbi.nlm.nih.gov/20704832
Autor:
Kendra A Williams, Minnkyong Lee, Ying Hu, Jonathan Andreas, Shashank J Patel, Suiyuan Zhang, Peter Chines, Abdel Elkahloun, Settara Chandrasekharappa, J Silvio Gutkind, Alfredo A Molinolo, Nigel P S Crawford
Publikováno v:
PLoS Genetics, Vol 10, Iss 11, p e1004809 (2014)
Although prostate cancer typically runs an indolent course, a subset of men develop aggressive, fatal forms of this disease. We hypothesize that germline variation modulates susceptibility to aggressive prostate cancer. The goal of this work is to id
Externí odkaz:
https://doaj.org/article/37dcb56c93a64c16bce461847a4a366a
Autor:
Mitsuaki Ono, Colette A Inkson, Robert Sonn, Tina M Kilts, Luis F de Castro, Azusa Maeda, Larry W Fisher, Pamela G Robey, Agnes D Berendsen, Li Li, Nancy McCartney-Francis, Aaron C Brown, Nigel P S Crawford, Alfredo Molinolo, Alka Jain, Neal S Fedarko, Marian F Young
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e71709 (2013)
Prostate cancer (PC) is a leading cause of death in men however the factors that regulate its progression and eventual metastasis to bone remain unclear. Here we show that WISP1/CCN4 expression in prostate cancer tissues was up-regulated in early sta
Externí odkaz:
https://doaj.org/article/d9b68d067f9747fd8bf3cf2c671ad8fb
Autor:
Nigel P S Crawford, Xiaolan Qian, Argyrios Ziogas, Alex G Papageorge, Brenda J Boersma, Renard C Walker, Luanne Lukes, William L Rowe, Jinghui Zhang, Stefan Ambs, Douglas R Lowy, Hoda Anton-Culver, Kent W Hunter
Publikováno v:
PLoS Genetics, Vol 3, Iss 11, p e214 (2007)
A novel candidate metastasis modifier, ribosomal RNA processing 1 homolog B (Rrp1b), was identified through two independent approaches. First, yeast two-hybrid, immunoprecipitation, and functional assays demonstrated a physical and functional interac
Externí odkaz:
https://doaj.org/article/024d35a8a3384db88bf5b2ceca00f697