Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Nigel P. Hurst"'
Autor:
Veena Dhillon, Euan McRorie, Alison Lochhead, Nigel P. Hurst, Sharron Sandhu, C. Michael Lambert
Publikováno v:
Arthritis & Rheumatism. 50:364-371
To examine whether dose escalation of intramuscular (IM) methotrexate (MTX) up to 45 mg/week improves disease control in patients who have active rheumatoid arthritis (RA) despite receiving conventional doses (15 mg/week) of IM MTX, and to obtain pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d03a988c7374e63000733df26e99bec6
https://doi.org/10.1002/art.20167
https://doi.org/10.1002/art.20167
Publikováno v:
Free Radical Biology and Medicine. 9:271-277
The Ca++ ionophore A23187 and phorbol 12-myristate 13-myristate 13-acetate (PMA) caused dose-dependent inhibition of phospholipid (PL) methylation in unfractionated mononuclear cells (MNC), monocytes, and lymphocytes as measured by incorporation of 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d3325463938024df4e7a47102efe3c9
https://doi.org/10.1016/0891-5849(90)90001-y
https://doi.org/10.1016/0891-5849(90)90001-y
Publikováno v:
Biochemical pharmacology. 39(7)
The effect of auranofin on the 5-lipoxygenase pathway was studied in human neutrophils stimulated with either fMLP or A23187 (with or without arachidonic acid). The synthesis of leukotriene B4 (LTB4), 5-HETE and the all-trans isomers of LTB4 was meas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fb35237c9ad6946d710583190d50a96
https://pubmed.ncbi.nlm.nih.gov/2157444
https://pubmed.ncbi.nlm.nih.gov/2157444
Autor:
C. Michael Lambert, Sharron Sandhu, Alison Lochhead, Nigel P. Hurst, Euan McRorie, Veena Dhillon
Publikováno v:
Arthritis & Rheumatism; Feb2004, Vol. 50 Issue 2, p364-371, 8p
Publikováno v:
Rheumatology International. 8:245-250
The effect of auranofin (AF) was examined on human neutrophil superoxide production and protein phosphorylation stimulated by phorbol esters. Low concentrations of auranofin (less than or equal to 0.5 microM) enhanced while higher concentrations (0.5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::007b1db473bbbf8a94c02c5f19c49e69
https://doi.org/10.1007/bf00270979
https://doi.org/10.1007/bf00270979
Publikováno v:
Annals of the Rheumatic Diseases. 46:750-756
The effect of chloroquine and hydroxychloroquine on neutrophil superoxide release stimulated by the chemotactic tripeptide N-formyl-methionyl-leucyl-phenylalanine (FMLP) was examined. Both drugs caused time and dose dependent inhibition of superoxide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4773c27d64d4921d23b8096214c890a1
https://doi.org/10.1136/ard.46.10.750
https://doi.org/10.1136/ard.46.10.750
Publikováno v:
Biochemical Pharmacology. 35:3083-3089
The 4-aminoquinolines chloroquine (CQ) and hydroxychloroquine (HCQ), and previously the 9-aminoacridine mepacrine (quinacrine) (MP), have been widely used in the treatment of inflammatory disorders such as rheumatoid arthritis and systemic lupus eryt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a575e3964e658907827ba469884e7dbb
https://doi.org/10.1016/0006-2952(86)90390-4
https://doi.org/10.1016/0006-2952(86)90390-4
Publikováno v:
Biochemical Pharmacology. 36:769-772
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::562d9275638d8f22bab5d0939a788ebf
https://doi.org/10.1016/0006-2952(87)90733-7
https://doi.org/10.1016/0006-2952(87)90733-7
Publikováno v:
Annals of the Rheumatic Diseases. 46:42-45
The accumulation of chloroquine and hydroxychloroquine in unfractionated mononuclear cells and in purified monocytes, lymphocytes, and neutrophil polymorphonuclear leucocytes (PMN) was measured in vitro. Accumulation of both drugs in leucocytes was t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::981563be5970d5f3c7cb0c8c8faf957c
https://doi.org/10.1136/ard.46.1.42
https://doi.org/10.1136/ard.46.1.42
Publikováno v:
Biochemical pharmacology. 37(7)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6896f44d0bf6b0e099e44aa49adbd372
https://pubmed.ncbi.nlm.nih.gov/3162678
https://pubmed.ncbi.nlm.nih.gov/3162678