Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Nigel P. Dolman"'
Autor:
Robert U. Muller, John R Huxter, David E. Jane, Graham L. Collingridge, Julia C. A. More, Nigel P. Dolman, Vernon R. J. Clarke, Larissa E. Zinyuk, Eva v. L. Roloff
Publikováno v:
The Journal of Neuroscience. 27:2212-2223
We investigated the role of kainate receptors in the generation of theta oscillations using (S)-1-(2-amino-2-carboxyethyl)-3-(2-carboxythiophene-3-yl-methyl)pyrimidine-2,4-dione (UBP304), a novel, potent and highly selective antagonist of GLUK5-conta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1b3ba6440bcf552f878a659e3f87dd0
https://doi.org/10.1523/jneurosci.3954-06.2007
https://doi.org/10.1523/jneurosci.3954-06.2007
Publikováno v:
British Journal of Pharmacology. 138:1093-1100
The natural product willardiine is an AMPA receptor agonist. We have examined the structural changes required to convert willardiine into an antagonist at AMPA and kainate receptors. Structure–activity analysis has been carried out to discover the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc3e52d18cd30741bdb3e67800159506
https://doi.org/10.1038/sj.bjp.0705148
https://doi.org/10.1038/sj.bjp.0705148
Autor:
Julia C. A. More, Olli T. Pentikäinen, Andrew Alt, David E. Jane, Jody L. Knauss, Mark Mayer, Graham L. Collingridge, Nigel P. Dolman, Carla R. Glasser, David Bleakman
Publikováno v:
Journal of medicinal chemistry. 50(7)
Some N3-substituted analogues of willardiine such as 11 and 13 are selective kainate receptor antagonists. In an attempt to improve the potency and selectivity for kainate receptors, a range of analogues of 11 and 13 were synthesized with 5-substitue
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d78e8cdba71299fd44215d3c3115c06
https://pubmed.ncbi.nlm.nih.gov/17348638
https://pubmed.ncbi.nlm.nih.gov/17348638
Autor:
Julia C. A. More, David E. Jane, Graham L. Collingridge, David Bleakman, Jody L. Knauss, Helen M Troop, Andrew Alt, Nigel P. Dolman
Publikováno v:
Journal of medicinal chemistry. 49(8)
N3-substitution of the uracil ring of willardiine with a variety of carboxyalkyl or carboxybenzyl substituents produces AMPA and kainate receptor antagonists. In an attempt to improve the potency and selectivity of these AMPA and kainate receptor ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4be89fe1089a0b7988e8bccaac13e48
https://pubmed.ncbi.nlm.nih.gov/16610801
https://pubmed.ncbi.nlm.nih.gov/16610801
Autor:
Jc-A More, E. C. Warburton, John Patrick Aggleton, Tim Koder, Nigel P. Dolman, Malcolm W. Brown, David E. Jane, Gareth R.I. Barker, Zafar I. Bashir, Yves Auberson
To investigate the involvement of different types of glutamate receptors in recognition memory, selective antagonists of NMDA and kainate receptors were locally infused into the perirhinal cortex of the rat temporal lobe. Such infusion of a selective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35a37971e4441cdb39b150c60a3eb238
https://europepmc.org/articles/PMC6673858/
https://europepmc.org/articles/PMC6673858/
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 26(11)
Glutamate receptor (GluR) ion channels mediate fast synaptic transmission in the mammalian CNS. Numerous crystallographic studies, the majority on the GluR2-subtype AMPA receptor, have revealed the structural basis for binding of subtype-specific ago
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1eb8353621f2b37ac56f7428f007209e
https://pubmed.ncbi.nlm.nih.gov/16540562
https://pubmed.ncbi.nlm.nih.gov/16540562
Autor:
David Bleakman, Nigel P. Dolman, Samantha Jack, David E Jane, Richard M. Morley, Julia C. A. More, Andrew Alt, Zuner A. Bortolotto, Robert Nisticò, Peter J. Roberts, Helen M Troop, Jody L. Knauss, Graham L. Collingridge
Publikováno v:
Journal of medicinal chemistry. 48(24)
The natural product willardiine (8) is an AMPA receptor agonist while 5-iodowillardiine (10) is a selective kainate receptor agonist. In an attempt to produce antagonists of kainate and AMPA receptors analogues of willardiine with substituents at the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::251754fe7ba85f935de7c0d98faf024f
https://pubmed.ncbi.nlm.nih.gov/16302825
https://pubmed.ncbi.nlm.nih.gov/16302825
Autor:
Julia C. A. More, Ann Marie L. Ogden, David E. Jane, Vernon R. J. Clarke, Zuner A. Bortolotto, Nigel P. Dolman, Fabio Pilato, Robert Nisticò, Andrew Alt, David Bleakman, Floris P. Buelens, Graham L. Collingridge, Helen M Troop, Eve E. Kelland
Willardiine derivatives with an N3-benzyl substituent bearing an acidic group have been synthesized with the aim of producing selective antagonists for GLUK5-containing kainate receptors. UBP296 was found to be a potent and selective antagonist of na
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa3f707d8a6a5ef58f76157c818b83e0
http://hdl.handle.net/11573/514325
http://hdl.handle.net/11573/514325
Publikováno v:
British journal of pharmacology. 138(6)
1. The natural product willardiine is an AMPA receptor agonist. We have examined the structural changes required to convert willardiine into an antagonist at AMPA and kainate receptors. Structure-activity analysis has been carried out to discover the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a3069ebf73bf5de037f3c0a38f5bbb9f
https://pubmed.ncbi.nlm.nih.gov/12684265
https://pubmed.ncbi.nlm.nih.gov/12684265
Autor:
Nigel P. Dolman, Julia C. A. More, Andrew Alt, Jody L. Knauss, Olli T. Pentikäinen, Carla R. Glasser, David Bleakman, Mark L. Mayer, Graham L. Collingridge, David E. Jane
Publikováno v:
Journal of Medicinal Chemistry; Apr2007, Vol. 50 Issue 7, p1558-1570, 13p