Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Nigel P Birch"'
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0165225 (2016)
Robust and reproducible in vitro models are required for investigating the pathways involved in fluid homeostasis in the human alveolar epithelium. We performed functional and phenotypic characterisation of ion transport in the human pulmonary epithe
Externí odkaz:
https://doaj.org/article/b2decea682804037b6fdf4b7d853e7af
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e91050 (2014)
Neuroserpin is a serine protease inhibitor, or serpin, that is expressed in the nervous system and inhibits the protease tissue plasminogen activator (tPA). Neuroserpin has been suggested to play a role in learning and memory but direct evidence for
Externí odkaz:
https://doaj.org/article/77b736a4934f46e0a7761bd838047505
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The ability to study migratory behavior of immune cells is crucial to understanding the dynamic control of the immune system. Migration induced by chemokines is often assumed to be directional (chemotaxis), yet commonly used end-point migration assay
Externí odkaz:
https://doaj.org/article/a59796d55cab41c9b4df328b0e8f314a
Publikováno v:
The Journal of biological chemistry. 298(7)
Plasmin is a broad-spectrum protease and therefore needs to be tightly regulated. Active plasmin is formed from plasminogen, which is found in high concentrations in the blood and is converted by the plasminogen activators. In the circulation, high l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bf3058f0ad8f09b057380668dffc98f
https://pubmed.ncbi.nlm.nih.gov/35690148
https://pubmed.ncbi.nlm.nih.gov/35690148
Autor:
Saem Park, Catherine E. Angel, Chun-Jen J. Chen, Claudia Mansell, Julie D. McIntosh, Adam Bartlett, Anna E. S. Brooks, P. Rod Dunbar, Evert Jan Loef, Hilary M. Sheppard, Jonathan Cebon, Nigel P. Birch
Publikováno v:
Immunology & Cell Biology. 99:49-64
B-cell migration within lymph nodes (LNs) is crucial to adaptive immune responses. Chemotactic gradients are proposed to drive migration of B cells into follicles, followed by their relocation to specific zones of the follicle during activation, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8997e34a43204a890861da8d4ea0f95
https://doi.org/10.1111/imcb.12386
https://doi.org/10.1111/imcb.12386
Autor:
Nigel P. Birch, Paul W. R. Harris, Margaret A. Brimble, Johanes K. Kasim, Jin Ng, Iman Kavianinia
Publikováno v:
Organic & Biomolecular Chemistry. 17:30-34
The amyloidogenic Aβ42 peptide was efficiently prepared using a double linker system, markedly improving solubility and chromatographic peak resolution, thus enabling full characterisation using standard techniques. The tag was readily cleaved with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d2b6ddb0b6262cda2167e47db86a212
https://doi.org/10.1039/c8ob02929f
https://doi.org/10.1039/c8ob02929f
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology
Frontiers in Immunology
The ability to study migratory behavior of immune cells is crucial to understanding the dynamic control of the immune system. Migration induced by chemokines is often assumed to be directional (chemotaxis), yet commonly used endpoint migration assays
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c1226b5513d53bda2722d2efd7fb0f8
https://doi.org/10.1101/2020.11.08.373548
https://doi.org/10.1101/2020.11.08.373548
Autor:
Harveen Kaur, Anthony J. R. Hickey, Anna E. S. Brooks, Margaret A. Brimble, Thomas A. Collier, Nigel P. Birch, Kevin Chang, Jane R. Allison, Jin Ng
Publikováno v:
J Biol Chem
Aβ1–42 is involved in Alzheimer's disease (AD) pathogenesis and is prone to glycation, an irreversible process where proteins accumulate advanced glycated end products (AGEs). N(ϵ)-(Carboxyethyl)lysine (CEL) is a common AGE associated with AD pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d67970bc3c19f6a1f113c7b0270f8d1
https://europepmc.org/articles/PMC6552435/
https://europepmc.org/articles/PMC6552435/
Publikováno v:
Journal of Molecular Neuroscience. 61:123-131
Oxidative stress plays a critical role in neuronal injury and is associated with various neurological diseases. Here, we explored the potential protective effect of neuroserpin against oxidative stress in primary cultured hippocampal neurons. Our res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::283393ea9f1b44124a8e50f2c4e1b807
https://doi.org/10.1007/s12031-016-0807-7
https://doi.org/10.1007/s12031-016-0807-7
Autor:
Johanes K, Kasim, Iman, Kavianinia, Jin, Ng, Paul W R, Harris, Nigel P, Birch, Margaret A, Brimble
Publikováno v:
Organicbiomolecular chemistry. 17(1)
The amyloidogenic Aβ42 peptide was efficiently prepared using a double linker system, markedly improving solubility and chromatographic peak resolution, thus enabling full characterisation using standard techniques. The tag was readily cleaved with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fc683e6cb6a45ee5639569fbe6adb772
https://pubmed.ncbi.nlm.nih.gov/30500032
https://pubmed.ncbi.nlm.nih.gov/30500032