Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Nigel P, Moore"'
Publikováno v:
International Journal of Cell Biology, Vol 2016 (2016)
The distribution of monocarboxylate transporter (MCT) isoforms 1 and 4, which mediate the plasmalemmal transport of l-lactic and pyruvic acids, has been identified in the placentae of rats and rabbits at different ages of gestation. Groups of three p
Externí odkaz:
https://doaj.org/article/ddfc3557934c4feb85f446a5d1eed720
Publikováno v:
Reproductive Toxicology. 78:102-110
Ethanolamine (EA) reduced implantation success in a two-generation reproduction toxicity study; the aim of this work was to explore the underlying basis for this response. When administered to pregnant rats during gestation days (GD) 1-3, 4-5, or 6-7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::638e3a1538529bd002f7538e84776f5b
https://doi.org/10.1016/j.reprotox.2018.04.005
https://doi.org/10.1016/j.reprotox.2018.04.005
Publikováno v:
Toxicological Sciences. 161:421-430
Ethylene glycol (EG) is a developmental toxicant in pregnant rats and mice. A suggested mechanism for this toxicity is that the EG metabolite, glycolic acid (GA), causes acidosis which may affect the embryonic heart rate (HR). This inhibition would c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b510eb35a0844a9dfc50a9b223feb16b
https://doi.org/10.1093/toxsci/kfx225
https://doi.org/10.1093/toxsci/kfx225
Autor:
Meagan B. Myers, Ying Chen, Sharon D. Shelton, Nigel P. Moore, Karen L. McKim, Bruce C. Allen, Martha M. Moore, Lynne T. Haber, B. Bhaskar Gollapudi, Barbara L. Parsons, Mugimane G. Manjanatha
Publikováno v:
Environmental and Molecular Mutagenesis. 58:122-134
Ethylene oxide (EO) is a direct acting alkylating agent; in vitro and in vivo studies indicate that it is both a mutagen and a carcinogen. However, it remains unclear whether the mode of action (MOA) for cancer for EO is a mutagenic MOA, specifically
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed1fdec9b10490be25ff4bec44c60b26
https://doi.org/10.1002/em.22080
https://doi.org/10.1002/em.22080
Autor:
Michael J. Bartels, Melissa R. Schisler, Matthew J. LeBaron, B. Bhaskar Gollapudi, Nigel P. Moore, Fagen Zhang
Publikováno v:
Biomedical Chromatography. 29:1364-1374
Glutathione (GSH), glutathione disulfide (GSSG) and 2-hydroxyethylated glutathione (HESG) are important biomarkers for exploring the genotoxicity mechanism of ethylene oxide (EO) or ethylene in vivo. A liquid chromatography–tandem mass spectrometry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2176ddcf6c92c6c49d68c9e2211db1d9
https://doi.org/10.1002/bmc.3432
https://doi.org/10.1002/bmc.3432
Comparative Response of Rat and Rabbit Conceptuses In Vitro to Inhibitors of Histiotrophic Nutrition
Autor:
Edward W. Carney, Kamin J. Johnson, Belen Tornesi, Nigel P. Moore, Valerie A. Marshall, Reza J. Rasoulpour
Publikováno v:
Birth Defects Research Part B: Developmental and Reproductive Toxicology. 104:1-10
Histiotrophic nutrition via the visceral yolk sac is an essential nutritional pathway of the rodent conceptus, and inhibition of this pathway may cause growth retardation, malformations, and death in rodent embryos. Morphologic differences among spec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3e3da39920938d1d3fd2b7930cee6b95
https://doi.org/10.1002/bdrb.21134
https://doi.org/10.1002/bdrb.21134
Autor:
Melissa R. Schisler, Fagen Zhang, Michael J. Bartels, Nigel P. Moore, B. Bhaskar Gollapudi, Matthew J. LeBaron, Yo-Chan Jeong
Publikováno v:
Journal of Chromatography B. :33-48
2-Hydroxyethylated and oxidative DNA nucleosides (DNA adduct biomarkers), such as O6-(2-hydroxyethyl)-2'-deoxyguanosine (O6HEdG), N6-(2-hydroxyethyl)-2'-deoxyadenosine (N6HEdA), 1-(2-hydroxyethyl)-2'-deoxyadenosine (N1HEdA), and 8-hydroxy-2'-deoxygua
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09039124f238a2805c6c5f954198ecae
https://doi.org/10.1016/j.jchromb.2014.10.042
https://doi.org/10.1016/j.jchromb.2014.10.042
Autor:
Martha M. Moore, Yiying Wang, Nigel P. Moore, Karen L. McKim, B. Bhaskar Gollapudi, Meagan B. Myers, Sharon D. Shelton, Lynne T. Haber, Mugimane G. Manjanatha, Barbara L. Parsons
Publikováno v:
Toxicological Sciences. 136:26-38
Ethylene oxide (EO) is a genotoxicant and a mouse lung carcinogen, but whether EO is carcinogenic through a mutagenic mode of action remains unclear. To investigate this question, 8-week-old male Big Blue B6C3F₁ mice (10 mice/group) were exposed to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6332a8c7c4b351dab03ac5bf0cd8d783
https://doi.org/10.1093/toxsci/kft190
https://doi.org/10.1093/toxsci/kft190
Autor:
Pilar Prieto, Nigel P. Moore, Tim G. Rowan, Thomas Holmes, Donald L. Bjerke, David J. Andrew, Stuart Creton, David Dreher, Troy Seidle
Publikováno v:
Regulatory Toxicology and Pharmacology. 66:30-37
Acute systemic toxicity data (LD50 values) and hazard classifications derived in the rat following oral administration and dermal application have been analysed to examine whether or not orally-derived hazard classification or LD50 values can be used
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02fef15e99f7fbff03a54dd4870e4d43
https://doi.org/10.1016/j.yrtph.2013.02.005
https://doi.org/10.1016/j.yrtph.2013.02.005
Autor:
Mugimane G, Manjanatha, Sharon D, Shelton, Ying, Chen, Barbara L, Parsons, Meagan B, Myers, Karen L, McKim, B Bhaskar, Gollapudi, Nigel P, Moore, Lynne T, Haber, Bruce, Allen, Martha M, Moore
Publikováno v:
Environmental and molecular mutagenesis. 58(3)
Ethylene oxide (EO) is a direct acting alkylating agent; in vitro and in vivo studies indicate that it is both a mutagen and a carcinogen. However, it remains unclear whether the mode of action (MOA) for cancer for EO is a mutagenic MOA, specifically
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::81060bb01377c1444a0042752d8b5121
https://pubmed.ncbi.nlm.nih.gov/28326610
https://pubmed.ncbi.nlm.nih.gov/28326610