Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Nigel O. Roome"'
Autor:
Nigel O. Roome, Catherine Lunven, Catherine Lecoffre, Bénédicte Roger, Nathalie Vivan, Danielle Garrigou-Gadenne, Christopher N. Berry, Pierre Lainée, Alain Rouchouse, Stephen E. O'Connor, Frederic Andre
Publikováno v:
Thrombosis and Haemostasis. 84:278-285
SummaryWe have studied the anticoagulant properties of a novel mixed micellar formulation containing 14 mg/ml argatroban administered by the sub-cutaneous (s. c.) route to rats, rabbits, dogs and primates. Blood samples were taken at various times po
Autor:
Nicolas, Fabre, Elsa, Arrivet, Françoise, Paillard, Valérie, Wibaut-Berlaimont, Nicole, Bichet, Nigel O, Roome, Annick, Prenez, Joan-Albert, Vericat
Publikováno v:
Alternatives to laboratory animals : ATLA. 32
Early toxicity screening of new drugs is performed to select candidates for development. Many cell models are used to assess basic cytotoxicity and to show a good correlation with acute toxicity. However, their correlation with chronic in vivo exposu
Autor:
Catherine Lecoffre, Donogh P. O’Brien, Christiane Gauffeny, Catherine Lunven, Nigel O. Roome, Christopher N. Berry
Publikováno v:
Thrombosis and Haemostasis. 75:154-169
SummaryClot-associated thrombin retains amidolytic activity, and is resistant to inhibition by heparin, but not to low molecular weight thrombin inhibitors. We show that clot-associated thrombin induces platelet aggregation, is resistant to heparin:a
Publikováno v:
Thrombosis and haemostasis. 80(5)
SummaryThe activation of rabbit platelets by rabbit plasma clots, and the inhibition of clot-associated thrombin by heparin:antithrombin III, recombinant hirudin (rHV2Lys47) and argatroban, a low molecular weight thrombin inhibitor, was studied.Plasm