Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Nigel M. Allanson"'
Publikováno v:
Org. Biomol. Chem.. 12:9291-9306
Modified nucleosides have received a great deal of attention from the scientific community, either for use as therapeutic agents, diagnostic tools, or as molecular probes. Perhaps the most difficult position of a nucleoside to modify is the 4'-positi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cc8fbc7ec5a3a3508c0fab8d44ef0f2
https://doi.org/10.1039/c4ob01449a
https://doi.org/10.1039/c4ob01449a
Publikováno v:
ChemInform. 46
Modified nucleosides have received a great deal of attention from the scientific community, either for use as therapeutic agents, diagnostic tools, or as molecular probes. Perhaps the most difficult position of a nucleoside to modify is the 4′-posi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6eb6164be990d3269f016cde6c347dcc
https://doi.org/10.1002/chin.201504252
https://doi.org/10.1002/chin.201504252
Autor:
Paul D. Tyler, Samantha Thomson, Ann Lewendon, John Barker, Lihua Zhao, William Ure Primrose, Nigel M. Allanson, John K.F. Maclean
Publikováno v:
European Journal of Medicinal Chemistry. 38:345-349
Phosphopantetheine adenylyltransferase (PPAT) is an essential enzyme in Coenzyme A biosynthesis. Because bacterial PPAT and mammalian PPAT are dissimilar, this enzyme is an attractive antibacterial target. Based on the structure of the substrate, 4-p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8be8cd7f19d8d0b210eb210073b88051
https://doi.org/10.1016/s0223-5234(03)00047-3
https://doi.org/10.1016/s0223-5234(03)00047-3
Autor:
Rui Liang, Chunguang Wang, Kiho Han, Nicole T. Hatzenbuhler, Buwen Huang, Muthoni G. Kamau, Helena R. Axelrod, Jan A. Anderson, Ramesh Kakarla, Neil Bristol, Anna Chen, Domingos J. Silva, Arthur Branstrom, Robert D. Goldman, Richard G. Dulina, Huiming Wang, Feng Chi, David Gange, Clifford B. Longley, Michael J. Sofia, Nigel M. Allanson, Dashan Liu, Rakesh K. Jain, Eugene R. Baizman, Natan A. Kogan, Sunita Midha
Publikováno v:
Journal of Medicinal Chemistry. 42:3193-3198
The increase in bacterial resistance to conventional chemotherapy has resulted in a resurgent interest in the discovery and development of antibacterial agents.1-4 The search for novel antibiotics active against resistant phenotypes is increasingly f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae445443dbe326863e7cdf3e76e733bc
https://doi.org/10.1021/jm990212a
https://doi.org/10.1021/jm990212a
Publikováno v:
The Journal of Organic Chemistry. 64:5926-5929
An efficient strategy to construct β-O-2-amino-2-deoxyglycopyranosidic linkages using glycosyl sulfoxides is demonstrated. Phenylsulfenyl 2-deoxy-2-trifluoroacetamido glycopyranosides were found to be reactive glycosyl donors in both solid- and solu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b4bd61539276d4423debc8095d15fe6f
https://doi.org/10.1021/jo9903499
https://doi.org/10.1021/jo9903499
Autor:
Anna Chen, Rakesh K. Jain, Liwu Hong, Dashan Liu, Manuka Ghosh, Feng Chi, Michael J. Sofia, Nigel M. Allanson
Publikováno v:
Tetrahedron Letters. 39:1889-1892
Jones reagent selectively oxidizes the primary hydroxyl of 1-thiophenyl glycosides in preference to oxidation at sulfur to give phenyl 1-thioglycopyranosiduronic acids in moderate to excellent yields.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f9842cc2ea82f5eedeeec5810027f75
https://doi.org/10.1016/s0040-4039(98)00155-5
https://doi.org/10.1016/s0040-4039(98)00155-5
Publikováno v:
Tetrahedron Letters. 37:8097-8100
Solid phase synthesis of peptidoglycan monomers was conducted by coupling the corresponding lipid-bearing glycocarboxylic acids to resin-bound peptides. The efficiency of coupling reagents was found to be in descending order of HATU>HBTU>PyBOP>EEDQ.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::885c7a3ea2607d8c5a2046029c8960f5
https://doi.org/10.1016/0040-4039(96)01849-7
https://doi.org/10.1016/0040-4039(96)01849-7
Autor:
Emma L. Blaney, David A. Griffith, Jeffrey T. Kohrt, Cathy Préville, James A. Southers, Scott W. Bagley, David J. Edmonds, Aaron C. Smith, Kim Huard, Matthew F. Dunn, Elnaz Menhaji-Klotz, Nigel M. Allanson, Robert L. Dow, Carmen N. Garcia-Irizarry, John C. Lucas
Publikováno v:
The Journal of organic chemistry. 77(22)
The synthesis of 4′,6′-dihydrospiro[piperidine-4,5′-pyrazolo[3,4-c]pyridin]-7′(2′H)-one-based acetyl-CoA carboxylase inhibitors is reported. The hitherto unknown N-2 tert-butyl pyrazolospirolactam core was synthesized from ethyl 3-amino-1H-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc67fd6c7915caac39c75274da65480d
https://pubmed.ncbi.nlm.nih.gov/23127254
https://pubmed.ncbi.nlm.nih.gov/23127254
Publikováno v:
Tetrahedron: Asymmetry. 5:2061-2076
Disaccharide mimics of the sialyl Lewis X (sLe x ) ligands have been prepared as potential antagonists of binding to the lectin domains of the E-selectin adhesion molecule. Versatile derivatives of sialic acid provide an entry to a series of simplifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf33e238f6628b13dfcc5e67f9580057
https://doi.org/10.1016/s0957-4166(00)86284-9
https://doi.org/10.1016/s0957-4166(00)86284-9
Publikováno v:
Tetrahedron Letters. 34:3945-3948
The syntheses of two novel disaccharides are described which block the interaction of the lectin domain of E-selectin with its glycosylated ligands on neutrophils.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::834f14278b590065c1da6dbfe472b121
https://doi.org/10.1016/s0040-4039(00)79271-9
https://doi.org/10.1016/s0040-4039(00)79271-9