Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Nigel M Stapleton"'
Autor:
Helga K Einarsdottir, Nigel M Stapleton, Sicco Scherjon, Jan Terje Andersen, Theo Rispens, C Ellen van der Schoot, Gestur Vidarsson
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e108319 (2014)
The neonatal receptor, FcRn, mediates both serum half-life extension as well as active transport of maternal IgG to the fetus during pregnancy. Therefore, transport efficiency and half-life go hand-in-hand. However, while the half-life of the human I
Externí odkaz:
https://doaj.org/article/3c1ace3f51f54d66ae8f880bd048a943
Autor:
Lorna M. Williamson, Charlene Porter, Gestur Vidarsson, S. Armstrong-Fisher, Nigel M. Stapleton, Kenneth Robert Page, Kathryn L. Armour, C. Ellen van der Schoot, Mike Clark, Donald Wilson Falconer, Masja de Haas, Jan Terje Andersen
Publikováno v:
Molecular immunology, 95, 1-9. Elsevier Limited
We have previously generated human IgG1 antibodies that were engineered for reduced binding to the classical Fcγ receptors (FcγRI–III) and C1q, thereby eliminating their destructive effector functions (constant region G1Δnab). In their potential
Autor:
Mariëlle J P Maas, C. Ellen van der Schoot, Maximilian Brinkhaus, Gestur Vidarsson, Wim J E van Esch, Juk Yee Mok, Arthur E. H. Bentlage, Steven W. de Taeye, A. Robin Temming, Lorna M. Williamson, Giso Brasser, Kathryn L. Armour, Mike Clark, Nigel M. Stapleton
Publikováno v:
Scientific reports, 9(1):7363. Nature Publishing Group
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Neonatal Fc-receptor (FcRn), the major histocompatibility complex (MHC) class I-like Fc-receptor, transports immunoglobuline G (IgG) across cell layers, extending IgG half-life in circulation and providing newborns with humoral immunity. IgG1 and IgG
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c8c490c504a73253465b55c5839610f
https://pure.amc.nl/en/publications/reduced-fcrnmediated-transcytosis-of-igg2-due-to-a-missing-glycine-in-its-lower-hinge(f84fbefd-a845-47a2-9e43-d541e9e077d0).html
https://pure.amc.nl/en/publications/reduced-fcrnmediated-transcytosis-of-igg2-due-to-a-missing-glycine-in-its-lower-hinge(f84fbefd-a845-47a2-9e43-d541e9e077d0).html
Publikováno v:
Immunological Reviews. 268:253-268
The neonatal Fc receptor, FcRn, is best known for its role in transporting IgG in various tissues, providing newborns with humoral immunity, and for prolonging the half-life of IgG. Recent findings implicate the involvement of FcRn in a far wider ran
Autor:
Suzanne E. Spliethoff, Gestur Vidarsson, Jan G. J. van de Winkel, Hans Janssen, Masja de Haas, Nigel M. Stapleton, Frank Rebers, Annette M. Stemerding
Publikováno v:
Blood, 108(10), 3573-3579. American Society of Hematology
Here, we report that the MHC class I-related neonatal Fc receptor (FcRn) is expressed within azurophilic and specific granules of neutrophils and relocates to phagolysosomes on phagocytosis of IgG-opsonized bacteria. We found FcRn to enhance phagocyt
Autor:
Masja de Haas, Yixian Zhao, Nigel M. Stapleton, Stefania P. Bjarnarson, Ruurd C. Verheul, Inger Sandlie, Ingileif Jonsdottir, Annette M. Stemerding, Jan Terje Andersen, Jorrit Gerritsen, Gestur Vidarsson, C. Ellen van der Schoot, Marion Kleijer
Publikováno v:
Nature Communications
Nature communications, 2. Nature Publishing Group
Nature communications, 2. Nature Publishing Group
Human IgG3 displays the strongest effector functions of all IgG subclasses but has a short half-life for unresolved reasons. Here we show that IgG3 binds to IgG-salvage receptor (FcRn), but that FcRn-mediated transport and rescue of IgG3 is inhibited