Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Nigel L, Barnett"'
Autor:
Elham Nili, Fiona J. Li, Rebecca A. Dawson, Cora Lau, Blair McEwan, Nigel L. Barnett, Steven Weier, Jennifer Walshe, Neil A. Richardson, Damien G. Harkin
Publikováno v:
Cell Transplantation, Vol 28 (2019)
While limbal epithelial cells are used for treating ocular surface wounds, the therapeutic potential of mesenchymal cells cultivated from the limbal stroma (LMSC) is less clear. We have therefore examined the effects of LMSC when applied to acute ocu
Externí odkaz:
https://doaj.org/article/692e48b9392c4a85b80680817beb57cd
Autor:
Sachin S Thakur, Micheal S Ward, Amirali Popat, Nicole B Flemming, Marie-Odile Parat, Nigel L Barnett, Harendra S Parekh
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0178305 (2017)
Herein we showcase the potential of ultrasound-responsive nanobubbles in enhancing macromolecular permeation through layers of the retina, ultimately leading to significant and direct intracellular delivery; this being effectively demonstrated across
Externí odkaz:
https://doaj.org/article/8c348a97c3884acaacf223e5babfeb97
Autor:
Ling Zhu, Rui Zhang, Weiyong Shen, Victoria Pye, Yoshio Hirabayashi, Pankaj Seth, Ashish Easow Mathai, Michelle Yam, Shigeki Furuya, So Ra Lee, James B. Hurley, Jianhai Du, Mark C Gillies, Cassie L. Rayner, Nigel L. Barnett
Publikováno v:
Glia. 69:1966-1986
The importance of Müller glia for retinal homeostasis suggests that they may have vulnerabilities that lead to retinal disease. Here, we studied the effect of selectively knocking down key metabolic genes in Müller glia on photoreceptor health. Imm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::414a12c47926918ee30dc941ef988985
https://doi.org/10.1002/glia.24005
https://doi.org/10.1002/glia.24005
Publikováno v:
Current Stem Cell Research & Therapy. 15:89-97
The retinal pigment epithelium (RPE) is a multifunctional monolayer located at the back of the eye required for the survival and function of the light-sensing photoreceptors. In Age-related Macular Degeneration (AMD), the loss of RPE cells leads to p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be6e2278ab5969f124e84c35ba982948
https://doi.org/10.2174/1574888x15666191218094020
https://doi.org/10.2174/1574888x15666191218094020
Publikováno v:
Experimental Eye Research. 173:24-31
Research is currently under way to produce tissue engineered corneal endothelium transplants for therapeutic use in humans. This work requires the use of model animals, both for the supply of corneal endothelial cells (CECs) for experimentation, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11603acb78b5ea2d16ffed418205c12b
https://doi.org/10.1016/j.exer.2018.04.011
https://doi.org/10.1016/j.exer.2018.04.011
Autor:
Nigel L. Barnett, Elham Nili, Neil A. Richardson, Steven Weier, Fiona J. Li, Jennifer Walshe, Rebecca A. Dawson, Damien G. Harkin, Blair McEwan, Cora Lau
Publikováno v:
Cell Transplantation, Vol 28 (2019)
Cell Transplantation
Cell Transplantation
While limbal epithelial cells are used for treating ocular surface wounds, the therapeutic potential of mesenchymal cells cultivated from the limbal stroma (LMSC) is less clear. We have therefore examined the effects of LMSC when applied to acute ocu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c8a262732fbb735425f19b0c1e711a4
https://doaj.org/article/692e48b9392c4a85b80680817beb57cd
https://doaj.org/article/692e48b9392c4a85b80680817beb57cd
Autor:
Damien G. Harkin, Neil A. Richardson, Nigel L. Barnett, Lawrence W. Hirst, Fiona J. Li, Jennifer Walshe, Elham Nili, Traian V. Chirila, Ivan R. Schwab, Brendan G. Cronin, Cora Lau
Publikováno v:
Experimental Eye Research. 147:1-11
The New Zealand White rabbit has been widely used as a model of limbal stem cell deficiency (LSCD). Current techniques for experimental induction of LSCD utilize caustic chemicals, or organic solvents applied in conjunction with a surgical limbectomy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::343579e457988e3b47703965989e3d01
https://doi.org/10.1016/j.exer.2016.04.005
https://doi.org/10.1016/j.exer.2016.04.005
Autor:
Jan Provis, Krisztina Valter, Haihan Jiao, Riccardo Natoli, Matt Rutar, Nilisha Fernando, Nigel L. Barnett
Publikováno v:
Experimental Eye Research. 147:114-127
Light-induced degeneration in rodent retinas is an established model for of retinal degeneration, including the roles of oxidative stress and neuroinflammatory activity. In these models, photoreceptor death is elicited via photo-oxidative stress, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72db128f1f4c6b6313eb08e9fb29d227
https://doi.org/10.1016/j.exer.2016.04.015
https://doi.org/10.1016/j.exer.2016.04.015
Publikováno v:
Neurochemistry International. 92:1-12
Nitroxides have been exploited as profluorescent probes for the detection of oxidative stress. In addition, they deliver potent antioxidant action and attenuate reactive oxygen species (ROS) in various models of oxidative stress, with these results a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4de6a54e0ce3dad1c3b693be1056d035
https://doi.org/10.1016/j.neuint.2015.11.003
https://doi.org/10.1016/j.neuint.2015.11.003
Autor:
Ilva D. Rupenthal, Nigel L. Barnett, Harendra S. Parekh, Kristofer J. Thurecht, Sachin S. Thakur, Zachary H. Houston, Nicholas L. Fletcher, Ying-Shan Chen
Publikováno v:
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 136
The intravitreal route faces many challenges in rapidly and effectively reaching posterior eye pathology, with administered therapeutics experiencing non-specific distribution around and premature clearance from ocular tissues. Nanobubbles and ultras
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e23f7e6427e41ee0229219a612956c86
https://pubmed.ncbi.nlm.nih.gov/30660691
https://pubmed.ncbi.nlm.nih.gov/30660691