Zobrazeno 1 - 10
of 582
pro vyhledávání: '"Nigel Klein"'
Autor:
Elena Morrocchi, Giuseppe R. Pascucci, Nicola Cotugno, Chiara Pighi, Sara Dominguez-Rodriguez, Maria Raffaella Petrara, Alfredo Tagarro, Louise Kuhn, Mark F. Cotton, Kennedy Otwombe, Maria G. Lain, Paula Vaz, Shaun L. Barnabas, Moira J. Spyer, Elisa Lopez, Sheila Fernández-Luis, Tacilta Nhampossa, Almoustapha I. Maiga, Oumar Dolo, Anita De Rossi, Pablo Rojo, Carlo Giaquinto, Mathias Lichterfeld, Avy Violari, Theresa Smit, Osee Behuhuma, Nigel Klein, Lesley De Armas, Savita Pahwa, Paolo Rossi, Paolo Palma, EPIICAL consortium
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract In this work our aim was to identify early biomarkers in plasma samples associated with mortality in children with perinatal HIV treated early in life, to potentially inform early intervention targeting this vulnerable group. 20/215 children
Externí odkaz:
https://doaj.org/article/286d2b323b6a46dda53e87d76b376c7c
Autor:
Victor Riitho, Roisin Connon, Agnes Gwela, Josephine Namusanje, Ruth Nhema, Abraham Siika, Mutsa Bwakura-Dangarembizi, Victor Musiime, James A. Berkley, Alex J. Szubert, Diana M. Gibb, A. Sarah Walker, Nigel Klein, Andrew J. Prendergast
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract One-third of people with HIV in sub-Saharan Africa start antiretroviral therapy (ART) with advanced disease. We investigated associations between immune biomarkers and mortality in participants with advanced HIV randomised to cotrimoxazole o
Externí odkaz:
https://doaj.org/article/ec3236ff775048d9b17003f3e68d0d64
Autor:
Ulla Ashorn, Christentze Schmiegelow, James Dodd, Feiko O ter Kuile, Simon Kariuki, Nigel Klein, Julie Gutman, Asma Khalil, Alphaxard Manjurano, Jenny Hill, Michael Alifrangis, Kamija S Phiri, R Matthew Chico, George Mtove, Kephas Otieno, Samwel Gesase, Reginald A Kavishe, Georgia R Gore-Langton, Mwayiwawo Madanitsa, Hellen C Barsosio, Daniel T R Minja, Jacklin Mosha, Omari A Msemo, John P A Lusingu, Crispin Mukerebe, Pius Ikigo, Queen Saidi, Eric D Onyango, Helle Hansson, Patricia Jean Hunter, Matt Cairns
Publikováno v:
BMJ Public Health, Vol 2, Iss 2 (2024)
Objectives Malaria and curable sexually transmitted and reproductive tract infections (STIs/RTIs) are associated with adverse pregnancy outcomes. This study reports the prevalence and risk factors of curable STIs/RTIs, STI/RTI co-infection and STI/RT
Externí odkaz:
https://doaj.org/article/f98092842edc45d48459298dcf0e3cb3
Autor:
Zhenguang Zhang, Iain R. L. Kean, Lisa M. Dratva, John A. Clark, Eleni Syrimi, Naeem Khan, Esther Daubney, Deborah White, Lauran O’Neill, Catherine Chisholm, Caroline Payne, Sarah Benkenstein, Klaudia Kupiec, Rachel Galassini, Victoria Wright, Helen Winmill, Ceri Robbins, Katherine Brown, Padmanabhan Ramnarayan, Barnaby Scholefield, Mark Peters, Nigel Klein, Hugh Montgomery, Kerstin B. Meyer, Sarah A. Teichmann, Clare Bryant, Graham Taylor, Nazima Pathan
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Multisystem inflammatory syndrome in children is a post-infectious presentation SARS-CoV-2 associated with expansion of the T cell receptor Vβ21.3+ T-cell subgroup. Here we apply muti-single cell omics to compare the inflammatory process in
Externí odkaz:
https://doaj.org/article/24631b7ed7a34550a699c037c3f5c247
Autor:
Juho Luoma, Laura Adubra, Dagmar Alber, Per Ashorn, Ulla Ashorn, Elaine Cloutman-Green, Fatoumata Diallo, Camilla Ducker, Riku Elovainio, Yue-Mei Fan, Lily Gates, Gwydion Gruffudd, Tiia Haapaniemi, Fadima Haidara, Lotta Hallamaa, Rikhard Ihamuotila, Nigel Klein, Owen Martell, Samba Sow, Taru Vehmasto, Yin Bun Cheung
Publikováno v:
Trials, Vol 24, Iss 1, Pp 1-13 (2023)
Abstract Background The Large-scale Assessment of the Key health-promoting Activities of two New mass drug administration regimens with Azithromycin (LAKANA) trial in Mali aims to evaluate the efficacy and safety of azithromycin (AZI) mass drug admin
Externí odkaz:
https://doaj.org/article/76e6e9a0b3b24f3586be0f89895eafdc
Autor:
Sergio Arredondo-Alonso, George Blundell-Hunter, Zuyi Fu, Rebecca A. Gladstone, Alfred Fillol-Salom, Jessica Loraine, Elaine Cloutman-Green, Pål J. Johnsen, Ørjan Samuelsen, Anna K. Pöntinen, François Cléon, Susana Chavez-Bueno, Miguel A. De la Cruz, Miguel A. Ares, Manivanh Vongsouvath, Agnieszka Chmielarczyk, Carolyne Horner, Nigel Klein, Alan McNally, Joice N. Reis, José R. Penadés, Nicholas R. Thomson, Jukka Corander, Peter W. Taylor, Alex J. McCarthy
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Escherichia coli is a leading cause of invasive bacterial infections in humans. Capsule polysaccharide has an important role in bacterial pathogenesis, and the K1 capsule has been firmly established as one of the most potent capsule types in
Externí odkaz:
https://doaj.org/article/e6fa52774e4f424f982560f7102a17a7
Autor:
Kathleen Gärtner, Sara Domínguez-Rodríguez, Judith Heaney, Triantafylia Gkouleli, Paul Grant, Karim Dorgham, Delphine Sauce, Cathia Soulie, Eloise J. Busby, Denise M. O’Sullivan, Moira Spyer, Johannes C. Botha, Maria Angeles Muñoz-Fernandez, Alfredo Tagarro, Nicola Cotugno, Jim F. Huggett, Nigel Klein, Paolo Palma, Pablo Rojo Conejo, Caroline Foster, Carlo Giaquinto, Paolo Rossi, Deborah Persaud, Anita De Rossi, Anne-Geneviève Marcelin, Eleni Nastouli
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionInitiation of antiretroviral treatment (ART) in patients early after HIV-infection and long-term suppression leads to low or undetectable levels of HIV RNA and cell-associated (CA) HIV DNA and RNA. Both CA-DNA and CA-RNA, overestimate the
Externí odkaz:
https://doaj.org/article/4ff5de9e0e7d46feaef69aac5332bac4
Autor:
Conor J. Higgins, Kerry-Anne Kite, Nigel Klein, Michael Super, Michael T. McCurdy, Darren Hargrave
Publikováno v:
Medical Mycology Case Reports, Vol 42, Iss , Pp 100614- (2023)
Fungemia negatively impacts patient outcomes, current diagnostics lack sensitivity to identify emerging rare mycoses, and fungal infections are increasing in prevalence, variety, and resistance. We report a case of Wickerhamomyces anomalus in an immu
Externí odkaz:
https://doaj.org/article/70ffdb4b80f34bf89138e457b5208ffb
Autor:
Alloys K’Oloo, Evance Godfrey, Annariina M. Koivu, Hellen C. Barsosio, Karim Manji, Veneranda Ndesangia, Fredrick Omiti, Mohamed Bakari Khery, Everlyne D. Ondieki, Simon Kariuki, Feiko O. ter Kuile, R. Matthew Chico, Nigel Klein, Otto Heimonen, Per Ashorn, Ulla Ashorn, Pieta Näsänen-Gilmore
Publikováno v:
Population Health Metrics, Vol 21, Iss 1, Pp 1-9 (2023)
Abstract Background Low birth weight (LBW) is a significant public health concern given its association with early-life mortality and other adverse health consequences that can impact the entire life cycle. In many countries, accurate estimates of LB
Externí odkaz:
https://doaj.org/article/f17cb089895d4afa926a87bbbb34b657
Autor:
Despina Eleftheriou, Yolanda Collaco Moraes, Cara Purvis, Molly Pursell, Marta Merida Morillas, Robin Kahn, Maria Mossberg, Filip Kucera, Robert Tulloh, Joseph F. Standing, Veronica Swallow, Rachael McCormack, Jethro Herberg, Michael Levin, Mandy Wan, Nigel Klein, Roisin Connon, Ann Sarah Walker, Paul Brogan
Publikováno v:
Trials, Vol 24, Iss 1, Pp 1-26 (2023)
Abstract Background Kawasaki disease (KD) is an acute self-limiting inflammatory vasculitis affecting predominantly medium-sized arteries, particularly the coronary arteries. A number of recent studies conducted in different European countries have d
Externí odkaz:
https://doaj.org/article/57f636ccf3b14656ad9a68aa88a4a0dd