Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Nigel J. Pearce"'
Autor:
Pieter H.E. Groot, Nigel J. Pearce, John W. Yates, Claire Stocker, Charles Sauermelch, Christopher P. Doe, Robert N. Willette, Alan Olzinski, Tambra Peters, Denise d'Epagnier, Kathleen O. Morasco, John A. Krawiec, Christine L. Webb, Karpagam Aravindhan, Beat Jucker, Mark Burgert, Chun Ma, Joseph P. Marino, Jon L. Collins, Colin H. Macphee, Scott K. Thompson, Michael Jaye
Publikováno v:
Journal of Lipid Research, Vol 46, Iss 10, Pp 2182-2191 (2005)
Liver X receptor (LXR) nuclear receptors regulate the expression of genes involved in whole body cholesterol trafficking, including absorption, excretion, catabolism, and cellular efflux, and possess both anti-inflammatory and antidiabetic actions. A
Externí odkaz:
https://doaj.org/article/a93b77eb6ebb42eda0f367c3bb33cfa8
Autor:
Jonathan R.S. Arch, Ed Wargent, Alastair Morrison, Gregory J. Murphy, Nigel J. Pearce, Carolyn A. Lister, Lynne Roxbee-Cox, Alexander J. Harper, Alejandro Abuin, Colleen M. Taylor, Andrea Llano, Stephen A. Smith, John C. Clapham, Gary B.T. Moore, Julie C. Holder, John W. Yates, Matthew P. Coghlan, Stacey L. Corcoran
Publikováno v:
Metabolism. 53:1322-1330
Glycogen synthase kinase-3 (GSK-3) protein levels and activity are elevated in skeletal muscle in type 2 diabetes, and inversely correlated with both glycogen synthase activity and insulin-stimulated glucose disposal. To explore this relationship, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::800a3b5ddbe68120ca1239fec3160f79
https://doi.org/10.1016/j.metabol.2004.05.008
https://doi.org/10.1016/j.metabol.2004.05.008
Publikováno v:
Current Medicinal Chemistry-Immunology, Endocrine & Metabolic Agents. 3:211-217
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a811c0efbe1014c502e67ca9b9e28d9
https://doi.org/10.2174/1568013033483357
https://doi.org/10.2174/1568013033483357
Autor:
Robert W. Ward, Stacey L. Corcoran, Gregory J. Murphy, Lynne Roxbee Cox, Julie C. Holder, David Haigh, Murray J. B. Brown, Olivier Lars SmithKline Beecham Pharmaceu. Rausch, Darren Cross, Ainsley A. Culbert, John W. Yates, Matthew P. Coghlan, Kenneth J. Murray, Smith David Glynn, Alastair D. Reith, Nigel J. Pearce, David Mills, Paul S. Carter
Publikováno v:
Chemistry & Biology. 7(10):793-803
Background: Glycogen synthase kinase-3 (GSK-3) is a serine/threonine protein kinase, the activity of which is inhibited by a variety of extracellular stimuli including insulin, growth factors, cell specification factors and cell adhesion. Consequentl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::542096d4c74f656602d387c9e0a7bdba
Autor:
David G. Tew, Patrick Camilleri, Patricia Sweeney, Nigel J. Pearce, Anthony N. Shaw, Theo A. Berkhout, John W. Yates, Brian Jackson, Helen F. Boyd, Pieter H. E. Groot, Andrew Derrick Gribble
Publikováno v:
Biochemical Journal. 334:113-119
ATP citrate (pro-S)-lyase (EC 4.1.3.8), a cytosolic enzyme that generates acetyl-CoA for cholesterol and fatty acid synthesis de novo, is a potential target for hypolipidaemic intervention. Here we describe the biological effects of the inhibition of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::07b90e7279f49fc3d28bbc236f1d1907
https://doi.org/10.1042/bj3340113
https://doi.org/10.1042/bj3340113
Autor:
David McNair, John W. Yates, Pieter H. E. Groot, Andrew Derrick Gribble, Brian Peter Slingsby, Mark D. Allen, Riccardo Novelli, Roland E. Dolle, C. E. Novelli, Barbara A. Saxty, Nigel J. Pearce, Virendra P. Shah, David G. Tew, Antony Nicholas Shaw
Publikováno v:
Journal of Medicinal Chemistry. 39:3569-3584
ATP-citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Inhibitors of the enzyme represent a potentially novel class of hypolipidemic agent, which are anticipated to have combined hypocholesterol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6171a47de2d6664a5d94441efcd14bc
https://doi.org/10.1021/jm960167w
https://doi.org/10.1021/jm960167w
Autor:
Brian Jackson, Van-Quyen Hoang, G. Martin Benson, Nigel J. Pearce, Kathleen M. Botham, Emelyn E. Eldredge, Keith Suckling
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism. 1210:73-80
The synthesis of bile acids by primary hamster hepatocytes in culture has been studied. Measurable rates of bile acid synthesis were obtained from cells prepared from livers of animals fed 2% w/w cholestyramine to induce the synthesis of bile acids t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88240f4dacbaea0df43b326b73258369
https://doi.org/10.1016/0005-2760(93)90051-a
https://doi.org/10.1016/0005-2760(93)90051-a
Autor:
Roland E. Dolle, Antony Nicholas Shaw, Andrew Derrick Gribble, John W. Yates, Virendra P. Shah, C. E. Novelli, Barbara A. Saxty, David G. Tew, Mark D. Allen, David McNair, Pieter H. E. Groot, Nigel J. Pearce, Brian Peter Slingsby, Riccardo Novelli
Publikováno v:
ChemInform. 27
ATP-citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Inhibitors of the enzyme represent a potentially novel class of hypolipidemic agent, which are anticipated to have combined hypocholesterol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d0bfd01a381ddc88b5a0b05d562b3b2e
https://doi.org/10.1002/chin.199652108
https://doi.org/10.1002/chin.199652108
Publikováno v:
Biochimica et biophysica acta. 1123(1)
Oral administration of cholestyramine to adult male hamsters not only induced a marked decrease in plasma concentrations of cholesterol and LDL but had a similar lowering effect on plasma triacyglycerol and VLDL concentrations. The hypotriglyceridaem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e14ebb66bd866c9b007f62486b7daa99
https://pubmed.ncbi.nlm.nih.gov/1730048
https://pubmed.ncbi.nlm.nih.gov/1730048
Publikováno v:
Atherosclerosis Supplements. 5:25
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7245202b80911632191efe34e4271928
https://doi.org/10.1016/s1567-5688(04)90110-4
https://doi.org/10.1016/s1567-5688(04)90110-4