Chronic oscillatory strain induces MLCK associated rapid recovery from acute stretch in airway smooth muscle cells

Autor: Darren J. Cole, Sarah C. Connolly, Carolyn A. Lall, Paul G. Smith, Nigel J. Fairbank, James D. MacKinnon, Geoffrey N. Maksym

Publikováno v: Journal of Applied Physiology. 111:955-963

A deep inspiration (DI) temporarily relaxes agonist-constricted airways in normal subjects, but in asthma airways are refractory and may rapidly renarrow, possibly due to changes in the structure and function of airway smooth muscle (ASM). Chronic la

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::760e4326a5bc7a29353570d87d2e4835
https://doi.org/10.1152/japplphysiol.00812.2009

Beneficial and harmful effects of oscillatory mechanical strain on airway smooth muscle

Autor: Geoffrey N. Maksym, Linhong Deng, Sarah C. Connolly, Carolyn A. Lall, Nigel J. Fairbank

Publikováno v: Canadian Journal of Physiology and Pharmacology. 83:913-922

Airway smooth muscle (ASM) cells are constantly under mechanical strain as the lung cyclically expands and deflates, and this stretch is now known to modulate the contractile function of ASM. However, depending on the experimental conditions, stretch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d83b7e5a26f88c83e901429c3f0c65b
https://doi.org/10.1139/y05-091

Airway smooth muscle dynamics: A common pathway of airway obstruction in asthma

Autor: Robert H. Brown, Alan L. James, Paul G. Smith, Kenneth R. Lutchen, Reinoud Gosens, Michael J. Sanderson, Lu Wang, S. H. Gilbert, R. H. Ingram, Thai Tran, Robert S. Tepper, David H. Eidelman, Peter D. Paré, Steven S. An, Geoffrey N. Maksym, Pasquale Chitano, Peter J. Sterk, Ben Fabry, Thomas M. Murphy, Newman L. Stephens, Darryl A. Knight, Linhong Deng, Thais Mauad, Richard W. Mitchell, William T. Gerthoffer, Paulo Sérgio Panse Silveira, Howard W. Mitchell, Alastair G. Stewart, O. J. Lakser, S. J. Gunst, Judith L. Black, Srboljub M. Mijailovich, Nigel J. Fairbank, James G. Martin, Dale D. Tang, Jeffrey J. Fredberg, Wayne Mitzner, Brent E. McParland, Mara S. Ludwig, Anne-Marie Lauzon, Tony R. Bai, Lincoln E. Ford, Charles G. Irvin, Vito Brusasco, R. Robert Schellenberg, Maria Dowell, Jason H. T. Bates, Luke J. Janssen, Chun Y. Seow, Riccardo Pellegrino, Gregory G. King, Julian Solway, Andrew J. Halayko

Publikováno v: European Respiratory Journal, 29(5), 834-860. EUROPEAN RESPIRATORY SOC JOURNALS LTD
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Excessive airway obstruction is the cause of symptoms and abnormal lung function in asthma. As airway smooth muscle (ASM) is the effecter controlling airway calibre, it is suspected that dysfunction of ASM contributes to the pathophysiology of asthma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b24686a9fa2268f5b2e31d26f3ab8fb
https://research.rug.nl/en/publications/95cf7433-f1f2-40a3-b46a-7c65c377eb70

Localized mechanical stress induces time-dependent actin cytoskeletal remodeling and stiffening in cultured airway smooth muscle cells

Autor: Ben Fabry, Geoffrey N. Maksym, Paul G. Smith, Linhong Deng, Nigel J. Fairbank

Publikováno v: American journal of physiology. Cell physiology. 287(2)

Mechanical stress (MS) causes cytoskeletal (CSK) and phenotypic changes in cells. Such changes in airway smooth muscle (ASM) cells might contribute to the pathophysiology of asthma. We have shown that periodic mechanical strain applied to cultured AS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0ce6abf3e9613cb0a6912a64135ef91
https://pubmed.ncbi.nlm.nih.gov/15070813