Zobrazeno 1 - 10
of 105
pro vyhledávání: '"Nigel J. Burroughs"'
Publikováno v:
IET Control Theory & Applications, Vol 18, Iss 13, Pp 1621-1637 (2024)
Abstract A new payoff function is proposed for cancer treatment optimisation, the tumour elimination payoff (TEP), that incorporates the increase in lifespan if tumour elimination is achieved. The TEP is discounted by drug toxicity and by potential r
Externí odkaz:
https://doaj.org/article/2deb96aad09e4baaa84e39c8d954c813
Autor:
Cédric Castrogiovanni, Alessio V. Inchingolo, Jonathan U. Harrison, Damian Dudka, Onur Sen, Nigel J. Burroughs, Andrew D. McAinsh, Patrick Meraldi
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Microtubules are built from GDP-tubulin lattices with small GTP caps at their plus-ends. Here, the authors reveal that microtubules that attach to kinetochores in mitosis contain, in addition to the GTP-cap and the GDP-lattices, a dynamic micron-size
Externí odkaz:
https://doaj.org/article/7374639fc1bf4c5e9e3d04d7bba621f4
Autor:
Tsvetelina E. Germanova, Emanuele Roscioli, Jonathan U. Harrison, Andrew D. McAinsh, Nigel J. Burroughs
Publikováno v:
STAR Protocols, Vol 2, Iss 4, Pp 100774- (2021)
Summary: This protocol measures the 3D Euclidean distance (Δ3D) between two/three fluorescently labeled kinetochore components in fixed samples using Kinetochore Delta software (KiDv1.0.1, MATLAB based). Overestimation of mean Δ3D is corrected thro
Externí odkaz:
https://doaj.org/article/7c410bd5af754cd2836e928d7012fddf
Autor:
Emanuele Roscioli, Tsvetelina E. Germanova, Christopher A. Smith, Peter A. Embacher, Muriel Erent, Amelia I. Thompson, Nigel J. Burroughs, Andrew D. McAinsh
Publikováno v:
Cell Reports, Vol 31, Iss 4, Pp - (2020)
Summary: Kinetochores are multi-protein machines that form dynamic attachments to microtubules and control chromosome segregation. High fidelity is ensured because kinetochores can monitor attachment status and tension, using this information to acti
Externí odkaz:
https://doaj.org/article/786ffb97659f4948ad237de50c3a4a33
Autor:
Aliyu A. Yusuf, Isabel P. Figueiredo, Atefeh Afsar, Nigel J. Burroughs, Alberto A. Pinto, Bruno M. P. M. Oliveira
Publikováno v:
Mathematics, Vol 8, Iss 2, p 293 (2020)
We study the equilibria of an Ordinary Differencial Equation (ODE) system where CD4 + effector or helper T cells and Regulatory T cells (Tregs) are present. T cells trigger an immune response in the presence of their specific antigen. Regulatory T ce
Externí odkaz:
https://doaj.org/article/b040bcf10ebc49d39a5def93a4e8df8b
Publikováno v:
PeerJ, Vol 2, p e645 (2014)
The impetus for this work was the need to analyse nucleotide diversity in a viral mix taken from honeybees. The paper has two findings. First, a method for correction of next generation sequencing error in the distribution of nucleotides at a site is
Externí odkaz:
https://doaj.org/article/cec08d4122824308b119183009b3e459
Autor:
Peter A Embacher, Tsvetelina E Germanova, Emanuele Roscioli, Andrew D McAinsh, Nigel J Burroughs
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 12, p e1010765 (2022)
Gaussian spot fitting methods have significantly extended the spatial range where fluorescent microscopy can be used, with recent techniques approaching nanometre (nm) resolutions. However, small inter-fluorophore distances are systematically over-es
Externí odkaz:
https://doaj.org/article/911f5eba65ac492a9901c38a7287b687
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 9, p e1007373 (2019)
Achieving global food security for the estimated 9 billion people by 2050 is a major scientific challenge. Crop productivity is fundamentally restricted by the rate of fixation of atmospheric carbon. The dedicated enzyme, RubisCO, has a low turnover
Externí odkaz:
https://doaj.org/article/57fcc08e543e42688f2fd9a11c2ecedf
Motivation Lattice light-sheet microscopy (LLSM) is revolutionizing cell biology since it enables fast, high-resolution extended imaging in three dimensions combined with a drastic reduction in photo-toxicity and bleaching. However, analysis of such
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::000821e2ae0c8e00244052fe3a941c6d
http://wrap.warwick.ac.uk/165825/1/WRAP-Kinetochore-tracking-3D-lattice-light-sheet-imaging-data-KiT-2022.pdf
http://wrap.warwick.ac.uk/165825/1/WRAP-Kinetochore-tracking-3D-lattice-light-sheet-imaging-data-KiT-2022.pdf
Autor:
Nigel J. Burroughs, Saravanan Palani, Mohan K. Balasubramanian, Paola Zambon, Anton Kamnev, Tom Cheffings
Publikováno v:
Molecular Biology of the Cell
Cytokinesis in many eukaryotes is dependent on a contractile actomyosin ring (AMR), composed of F-actin, myosin II, and other actin and myosin II regulators. Through fluorescence recovery after photobleaching experiments, many components of the AMR h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdf167aad01285632ce471e830ceea68
http://europepmc.org/articles/PMC8098825
http://europepmc.org/articles/PMC8098825