The role of palmitoylation in signalling, cellular trafficking and plasma membrane localization of protease-activated receptor-2.

Autor: Mark N Adams, Melinda E Christensen, Yaowu He, Nigel J Waterhouse, John D Hooper

Publikováno v: PLoS ONE, Vol 6, Iss 11, p e28018 (2011)

Protease-activated receptor-2 (PAR2) is a G protein coupled receptor (GPCR) activated by proteolytic cleavage of its amino terminal domain by trypsin-like serine proteases. This irreversible activation mechanism leads to rapid receptor desensitizatio

Externí odkaz: https://doaj.org/article/f2ecd71eee0e488cad866f6eccbae9b5

Human peripheral blood DNAM-1neg NK cells are a terminally differentiated subset with limited effector functions

Autor: Nigel J. Waterhouse, Mark J. Smyth, Ludovic Martinet, Frank Vari, Lucienne Chatenoud, Maher K. Gandhi, Sébastien Lemoine, Camille Guillerey, Kimberley Stannard

Publikováno v: Blood Advances. 3:1681-1694

Natural killer (NK) cells are a heterogeneous population of innate lymphocytes whose potent anticancer properties make them ideal candidates for cellular therapeutic application. However, our lack of understanding of the role of NK cell diversity in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5d469aa20d49c5ff5a1e7b3cbfa9bf27
https://doi.org/10.1182/bloodadvances.2018030676

Human papillomavirus E7 oncoprotein expression by keratinocytes alters the cytotoxic mechanisms used by CD8 T cells

Autor: Anne-Sophie Bergot, Purnima Bhat, Nigel J. Waterhouse, Ian H. Frazer

Publikováno v: Oncotarget

Cervical cancer is a malignant transformation of keratinocytes initiated by the E7 oncoprotein of human papillomavirus (HPV). These tumors are characterized by keratinocyte hyperproliferation and are often infiltrated with activated CD8 T cells. HPV

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::764e749675a877132446204be4172c2a
https://doi.org/10.18632/oncotarget.23210

Human peripheral blood DNAM-1

Autor: Kimberley A, Stannard, Sébastien, Lemoine, Nigel J, Waterhouse, Frank, Vari, Lucienne, Chatenoud, Maher K, Gandhi, Ludovic, Martinet, Mark J, Smyth, Camille, Guillerey

Publikováno v: Blood advances. 3(11)

Natural killer (NK) cells are a heterogeneous population of innate lymphocytes whose potent anticancer properties make them ideal candidates for cellular therapeutic application. However, our lack of understanding of the role of NK cell diversity in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::69607bf2d76db4dc91080d6e6caef604
https://pubmed.ncbi.nlm.nih.gov/31167820

Oncosis and apoptosis induction by activation of an overexpressed ion channel in breast cancer cells

Autor: Elena Pera, Michael J. G. Milevskiy, Paraic A. Kenny, Daneth L. Marcial, Kunsala T. D. S. Yapa, Nigel J. Waterhouse, Silke B. Chalmers, Peter J. Cabot, Gregory R. Monteith, S. Y. N. Jamaludin, Thomas J. Gonda, Melissa A. Brown, Eloise Dray, Iman Azimi, Sarah J. Roberts-Thomson, Adrian P. Wiegmans, Kum Kum Khanna, H. Lim, Amelia A. Peters, Korinne Northwood, Felicity M. Davis

Publikováno v: Peters, A A, Jamaludin, S Y N, Yapa, K T D S, Chalmers, S, Wiegmans, A P, Lim, H F, Milevskiy, M J G, Azimi, I, Davis, F M, Northwood, K S, Pera, E, Marcial, D L, Dray, E, Waterhouse, N J, Cabot, P J, Gonda, T J, Kenny, P A, Brown, M A, Khanna, K K, Roberts-Thomson, S J & Monteith, G R 2017, ' Oncosis and apoptosis induction by activation of an overexpressed ion channel in breast cancer cells ', Oncogene, bind 36, nr. 46, s. 6490-6500 .
Aarhus University

The critical role of calcium signalling in processes related to cancer cell proliferation and invasion has seen a focus on pharmacological inhibition of overexpressed ion channels in specific cancer subtypes as a potential therapeutic approach. Howev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59b21e309ab6df992517676a5de65abc
https://hdl.handle.net/11541.2/133849