Zobrazeno 1 - 10
of 211
pro vyhledávání: '"Nigel J Pyne"'
Autor:
Evgeny V Berdyshev, Irina Gorshkova, Peter Usatyuk, Satish Kalari, Yutong Zhao, Nigel J Pyne, Susan Pyne, Roger A Sabbadini, Joe G N Garcia, Viswanathan Natarajan
Publikováno v:
PLoS ONE, Vol 6, Iss 1, p e16571 (2011)
Earlier we have shown that extracellular sphingosine-1-phosphate (S1P) induces migration of human pulmonary artery endothelial cells (HPAECs) through the activation of S1P(1) receptor, PKCε, and PLD2-PKCζ-Rac1 signaling cascade. As endothelial cell
Externí odkaz:
https://doaj.org/article/cc99e3f2d99b49cfbd0f1ee6c9092044
Autor:
Afonso R. M. Almeida, João L. Neto, Ana Cachucho, Mayara Euzébio, Xiangyu Meng, Rathana Kim, Marta B. Fernandes, Beatriz Raposo, Mariana L. Oliveira, Daniel Ribeiro, Rita Fragoso, Priscila P. Zenatti, Tiago Soares, Mafalda R. de Matos, Juliana Ronchi Corrêa, Mafalda Duque, Kathryn G. Roberts, Zhaohui Gu, Chunxu Qu, Clara Pereira, Susan Pyne, Nigel J. Pyne, Vasco M. Barreto, Isabelle Bernard-Pierrot, Emannuelle Clappier, Charles G. Mullighan, Ana R. Grosso, J. Andrés Yunes, João T. Barata
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Interleukin-7 receptor alpha (IL7Ra) is important for lymphoid cell development but its role in leukaemogenesis is not clear. Here, the authors generate a knock-in murine model to show that activating mutations in IL7Ra can initiate precursor B-cell
Externí odkaz:
https://doaj.org/article/83e6d6932423405685472917e2af4d77
Autor:
Susan Pyne, Nigel J Pyne
Publikováno v:
IUPHAR/BPS Guide to Pharmacology CITE. 2023
S1P (sphingosine 1-phosphate) is a bioactive lipid which, after release from cells via certain transporters, acts as a ligand for a family of five S1P-specific G protein-coupled receptors (S1P1-5). However, it also has a number of intracellular targe
Autor:
Sun-Hye Shin, Hee-Yeon Kim, Hee-Soo Yoon, Woo-Jae Park, David R. Adams, Nigel J. Pyne, Susan Pyne, Joo-Won Park
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 21, p 8371 (2020)
Sphingosine kinases (SK) catalyze the phosphorylation of sphingosine to generate sphingosine-1-phosphate. Two isoforms of SK (SK1 and SK2) exist in mammals. Previously, we showed the beneficial effects of SK2 inhibition, using ABC294640, in a psorias
Externí odkaz:
https://doaj.org/article/1f4ba4832f314af19f71c708a3affd1c
Autor:
Federico Torta, Jeongah Oh, Mariam Alsanafi, Susan Pyne, David R. Adams, Ryan D. R. Brown, Nigel J. Pyne
Publikováno v:
Cell Biochemistry and Biophysics
Dihydroceramide desaturase (Degs1) catalyses the introduction of a 4,5-trans double bond into dihydroceramide to form ceramide. We show here that Degs1 is polyubiquitinated in response to retinol derivatives, phenolic compounds or anti-oxidants in HE
Autor:
Stephen P H Alexander, Doriano Fabbro, Eamonn Kelly, Alistair Mathie, John A Peters, Emma L Veale, Jane F Armstrong, Elena Faccenda, Simon D Harding, Adam J Pawson, Christopher Southan, Jamie A Davies, Stephanie Annett, Detlev Boison, Kathryn Elisa Burns, Carmen Dessauer, Jürg Gertsch, Nuala Ann Helsby, Angelo A. Izzo, Doris Koesling, Rennolds Ostrom, Andreas Papapetropoulos, Nigel J. Pyne, Susan Pyne, Tracy Robson, Michael Russwurm, Roland Seifert, Johannes‐Peter Stasch, Csaba Szabo, Mario van der Stelt, Albert van der Vliet, Val Watts, Szu Shen Wong
Publikováno v:
Alexander, Stephen Ph; Fabbro, Doriano; Kelly, Eamonn; Mathie, Alistair; Peters, John A; Veale, Emma L; Armstrong, Jane F; Faccenda, Elena; Harding, Simon D; Pawson, Adam J; Southan, Christopher; Davies, Jamie A; Boison, Detlev; Burns, Kathryn Elisa; Dessauer, Carmen; Gertsch, Jürg; Helsby, Nuala Ann; Izzo, Angelo A; Koesling, Doris; Ostrom, Rennolds; ... (2021). THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Enzymes. British journal of pharmacology, 178(Suppl. 1), S313-S411. Wiley 10.1111/bph.15542
The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with an emphasis on select
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d121ee1cf530f801dfca85582efb2536
https://boris.unibe.ch/161549/1/bph.15542.pdf
https://boris.unibe.ch/161549/1/bph.15542.pdf
Autor:
Nigel J. Pyne, Rothwelle J. Tate, Federico Torta, David R. Adams, Jeongah Oh, Susan Pyne, Ryan D. R. Brown, Margaret R. Cunningham, Ben E.P. Veerman
Publikováno v:
The Journal of Biological Chemistry
The translocation of sphingosine kinase 1 (SK1) to the plasma membrane (PM) is crucial in promoting oncogenesis. We have previously proposed that SK1 exists as both a monomer and dimer in equilibrium, although it is unclear whether these species tran
Autor:
Tarek A.M. Almabrouk, Simon Kennedy, Husam S.F. Alganga, Craig J. Daly, Susan Pyne, Omar J. Katwan, Nigel J. Pyne
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 371:63-74
Sphingosine kinase [(SK), isoforms SK1 and SK2] catalyzes the formation of the bioactive lipid, sphingosine 1-phosphate (S1P). This can be exported from cells and bind to S1P receptors to modulate vascular function. We investigated the effect of shor
Autor:
Liliana Schaefer, David R. Adams, Gerd Geisslinger, Stephanie Schwalm, Andrea Huwiler, Redona Hafizi, Susan Pyne, Sandra Trautmann, Sandra Beyer, Nigel J. Pyne, Josef Pfeilschifter
Renal fibrosis is characterized by chronic inflammation and excessive accumulation of extracellular matrix and progressively leads to functional insufficiency and even total loss of kidney function. In this study we investigated the anti-fibrotic pot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a7de8ea7a46c8610729b233dfd2be23
https://strathprints.strath.ac.uk/74881/1/Schwalm_etal_CS_2020_Validation_of_highly_selective_Sphingosine_kinase_2_inhibitors_SLM6031434_and_HWG_35D.pdf
https://strathprints.strath.ac.uk/74881/1/Schwalm_etal_CS_2020_Validation_of_highly_selective_Sphingosine_kinase_2_inhibitors_SLM6031434_and_HWG_35D.pdf
The sphingosine kinases, SK1 and SK2, catalyse the formation of the bioactive signalling lipid, sphingosine 1-phosphate (S1P), from sphingosine. SK1 and SK2 differ in their subcellular localisation, trafficking and regulation, but the isoforms are al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bd4d0bdc49b566ae9754dbfa765b895
https://strathprints.strath.ac.uk/74186/1/Adams_etal_CS_2021_Structure_function_analysis_of_lipid_substrates_and_inhibitors_of_sphingosine_kinases.pdf
https://strathprints.strath.ac.uk/74186/1/Adams_etal_CS_2021_Structure_function_analysis_of_lipid_substrates_and_inhibitors_of_sphingosine_kinases.pdf