Zobrazeno 1 - 10
of 125
pro vyhledávání: '"Nigel J, Temperton"'
Autor:
Hannah Klim, Timothy William, Jack Mellors, Caolann Brady, Giri S. Rajahram, Tock H. Chua, Helena Brazal Monzó, Jecelyn Leslie John, Kelly da Costa, Mohammad Saffree Jeffree, Nigel J. Temperton, Tom Tipton, Craig P. Thompson, Kamruddin Ahmed, Chris J. Drakeley, Miles W. Carroll, Kimberly M. Fornace
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Cases of H5 highly pathogenic avian influenzas (HPAI) are on the rise. Although mammalian spillover events are rare, H5N1 viruses have an estimated mortality rate in humans of 60%. No human cases of H5 infection have been reported in Malaysi
Externí odkaz:
https://doaj.org/article/bd933e2d3cc94517949f10657ffb0d2d
Autor:
Iman Rabeeah, Elizabeth Billington, Béatrice Nal, Jean-Remy Sadeyen, Ansar A. Pathan, Munir Iqbal, Nigel J. Temperton, Peter F. Zipfel, Christine Skerka, Uday Kishore, Holly Shelton
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
The complement system is an innate immune mechanism against microbial infections. It involves a cascade of effector molecules that is activated via classical, lectin and alternative pathways. Consequently, many pathogens bind to or incorporate in the
Externí odkaz:
https://doaj.org/article/8881a6fce7e34af3bf188ad7f814d058
Publikováno v:
Pathogens, Vol 13, Iss 8, p 679 (2024)
The emergence of SARS-CoV-2 has meant that pandemic preparedness has become a major focus of the global scientific community. Gathered in the historic St Edmund Hall college in Oxford, the one-day LPMHealthcare conference on emerging viruses (6 Septe
Externí odkaz:
https://doaj.org/article/93cbbbddd6cb4b8aab779be1480f7969
Autor:
Phil Palmer, Joanne Marie M. Del Rosario, Kelly A. S. da Costa, George W. Carnell, Chloe Q. Huang, Jonathan L. Heeney, Nigel J. Temperton, David A. Wells
Publikováno v:
Frontiers in Immunology, Vol 12 (2022)
The emergence of COVID-19 has emphasised that biological assay data must be analysed quickly to develop safe, effective and timely vaccines/therapeutics. For viruses such as SARS-CoV-2, the primary way of measuring immune correlates of protection is
Externí odkaz:
https://doaj.org/article/140474e3b6c44356aae37ed106c04bc8
Autor:
Javier Castillo-Olivares, David A. Wells, Matteo Ferrari, Andrew C. Y. Chan, Peter Smith, Angalee Nadesalingam, Minna Paloniemi, George W. Carnell, Luis Ohlendorf, Diego Cantoni, Martin Mayora-Neto, Phil Palmer, Paul Tonks, Nigel J. Temperton, David Peterhoff, Patrick Neckermann, Ralf Wagner, Rainer Doffinger, Sarah Kempster, Ashley D. Otter, Amanda Semper, Tim Brooks, Anna Albecka, Leo C. James, Mark Page, Wilhelm Schwaeble, Helen Baxendale, Jonathan L. Heeney
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Precision monitoring of antibody responses during the COVID-19 pandemic is increasingly important during large scale vaccine rollout and rise in prevalence of Severe Acute Respiratory Syndrome-related Coronavirus-2 (SARS-CoV-2) variants of concern (V
Externí odkaz:
https://doaj.org/article/83c33cb02bac4ce88d2084a406ccc680
Autor:
Kelly A. S. da Costa, Joanne Marie M. Del Rosario, Matteo Ferrari, Sneha Vishwanath, Benedikt Asbach, Rebecca Kinsley, Ralf Wagner, Jonathan L. Heeney, George W. Carnell, Nigel J. Temperton
Publikováno v:
Vaccines, Vol 10, Iss 9, p 1520 (2022)
To better understand how inhibition of the influenza neuraminidase (NA) protein contributes to protection against influenza, we produced lentiviral vectors pseudotyped with an avian H11 hemagglutinin (HA) and the NA of all influenza A (N1–N9) subty
Externí odkaz:
https://doaj.org/article/1f440601fb19487f84e9944df055f866
Autor:
Craig P. Thompson, José Lourenço, Adam A. Walters, Uri Obolski, Matthew Edmans, Duncan S. Palmer, Kreepa Kooblall, George W. Carnell, Daniel O’Connor, Thomas A. Bowden, Oliver G. Pybus, Andrew J. Pollard, Nigel J. Temperton, Teresa Lambe, Sarah C. Gilbert, Sunetra Gupta
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Current influenza vaccine approaches largely focus on highly variable epitopes with high immunogenicity or epitopes of low variability that often have low immunogenicity. Here, Thompson et al. identify a highly immunogenic epitope of limited variabil
Externí odkaz:
https://doaj.org/article/c958d9080c9c42db8c6590f1627c062e
Autor:
Joanne Marie M. Del Rosario, Kelly A. S. da Costa, Benedikt Asbach, Francesca Ferrara, Matteo Ferrari, David A. Wells, Gurdip Singh Mann, Veronica O. Ameh, Claude T. Sabeta, Ashley C. Banyard, Rebecca Kinsley, Simon D. Scott, Ralf Wagner, Jonathan L. Heeney, George W. Carnell, Nigel J. Temperton
Publikováno v:
Vaccines, Vol 9, Iss 7, p 741 (2021)
We developed an influenza hemagglutinin (HA) pseudotype library encompassing Influenza A subtypes HA1-18 and Influenza B subtypes (both lineages) to be employed in influenza pseudotype microneutralization (pMN) assays. The pMN is highly sensitive and
Externí odkaz:
https://doaj.org/article/20645bc3db454cf08ad9a355855ec117
Autor:
George W. Carnell, Claudia M. Trombetta, Francesca Ferrara, Emanuele Montomoli, Nigel J. Temperton
Publikováno v:
Vaccines, Vol 9, Iss 2, p 100 (2021)
Influenza B is responsible for a significant proportion of the global morbidity, mortality and economic loss caused by influenza-related disease. Two antigenically distinct lineages co-circulate worldwide, often resulting in mismatches in vaccine cov
Externí odkaz:
https://doaj.org/article/9af98952c8cd4de586a7c6f52c827217
Autor:
Yue Du, Kamran M Miah, Omar Habib, Helena Meyer-Berg, Catriona C Conway, Mariana A Viegas, Rebecca Dean, Dwiantari Satyapertiwi, Jincun Zhao, Yanqun Wang, Nigel J Temperton, Toby P E Gamlen, Deborah R Gill, Stephen C Hyde
Publikováno v:
Thorax. 77:1229-1236
BackgroundThe COVID-19 pandemic continues to be a worldwide threat and effective antiviral drugs and vaccines are being developed in a joint global effort. However, some elderly and immune-compromised populations are unable to raise an effective immu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49b3e9155f92e16f44421988c17acda5
https://doi.org/10.1136/thoraxjnl-2021-217650
https://doi.org/10.1136/thoraxjnl-2021-217650