Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Nigel Hurst"'
Publikováno v:
Osteoporosis International. 16:483-489
Objectives: There have been no studies of generic health-related quality of life (HR-QOL) measured prospectively, in patients referred for bone mass measurement. The aim of this study was to examine the relationship between HR-QOL, measured before DX
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5a509c39f5e247481f2a4e8a890c881
https://doi.org/10.1007/s00198-004-1705-3
https://doi.org/10.1007/s00198-004-1705-3
Publikováno v:
Osteoporosis International. 14:326-333
The objective of the study was to assess the impact of direct access DXA scanning (DADS) upon GPs' management decisions in patients considered to be at risk of osteoporosis. It was designed as a randomized, prospective, parallel group trial, set with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c905acb8328c8d9e028ce1a6e9eeffe
https://doi.org/10.1007/s00198-002-1371-2
https://doi.org/10.1007/s00198-002-1371-2
Autor:
Roy L. Beddoes, David Nigel Hurst, Michael Richard Attwood, Peter Quayle, M. L. Lewis, Y. Zhao
Publikováno v:
Tetrahedron Letters. 36:2641-2644
Steric rather than electrostatic interactions have been shown to be the controlling factor in the stereochemistry of enolate generation of β-trialkylstannylpropionates.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6515d79795daa8aa8b19c04e6bb691f8
https://doi.org/10.1016/0040-4039(95)00303-t
https://doi.org/10.1016/0040-4039(95)00303-t
Autor:
Michael Richard Attwood, Sanjit Johal, David Nigel Hurst, Peter Quayle, M. L. Lewis, Roy L. Beddoes
Publikováno v:
Tetrahedron Letters. 36:471-474
A stereospecific 1,3-elimination reaction of γ-hydroxy stannanes has been employed in the synthesis of 2-oxabicyclo[3.1.0]hexanes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f61b7d77bbfd72ecab28c1e5b7ccbb27
https://doi.org/10.1016/0040-4039(94)02289-n
https://doi.org/10.1016/0040-4039(94)02289-n
Publikováno v:
ChemInform. 22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::439af32d7505e9448ed7a6856742f3b5
https://doi.org/10.1002/chin.199151198
https://doi.org/10.1002/chin.199151198
Autor:
Y. Zhao, Michael Richard Attwood, Peter Quayle, Roy L. Beddoes, M. L. Lewis, David Nigel Hurst
Publikováno v:
ChemInform. 26
Steric rather than electrostatic interactions have been shown to be the controlling factor in the stereochemistry of enolate generation of β-trialkylstannylpropionates.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d1f4ec747a1348dab282c55e0824616
https://doi.org/10.1002/chin.199532142
https://doi.org/10.1002/chin.199532142
Autor:
David Nigel Hurst, Rachel M. Dunsdon, Michael Richard Attwood, Kay Paul Brittain, P. Jones, Barbara S. Brown
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 2:229-234
The preparation of several homochiral benzopyranyl potassium channel openers is described. A subtle stereochemical effect of the 3-hydroxyl group on the biological activities of the enantiomers was observed.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::83ff092764657c77ea46914258b67f5e
https://doi.org/10.1016/s0960-894x(01)81070-2
https://doi.org/10.1016/s0960-894x(01)81070-2
Autor:
David Spalding, Adrian Hall, Gerard Martin Paul Giblin, Nicholas Maughan Clayton, Rino A. Bit, Tiziana Scoccitti, Iain P. Chessell, Anita Chowdhury, Riccardo Novelli, David Nigel Hurst, Alan Naylor, Alex W. Wilson, Helene M. Chaignot, Sac P. Tang, Susan H. Brown, Rich Wilson, Beverley Hammond, Anton D. Michel, Tanya Coleman
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(2)
The discovery of a series of selective EP1 receptor antagonists based on a 1,2-diarylcyclopentene template is described. After defining the structural requirements for EP1 potency and selectivity, heterocyclic rings were incorporated to reduce log D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7e9b9eff5bda17de702d63fb35717de
https://pubmed.ncbi.nlm.nih.gov/17084082
https://pubmed.ncbi.nlm.nih.gov/17084082
Autor:
Michael J. Broadhurst, Trevor C.I. Wilkinson, Stephen D. Pickett, P. Jones, Murray McKinnell, James M. Bennett, Bradley S Sherborne, Neera Borkakoti, David Nigel Hurst, Ian Reginald Kilford
Publikováno v:
Bioorganicmedicinal chemistry letters. 13(10)
Novel, low molecular weight inhibitors of IMPDH have been discovered through the application of a validated virtual screening protocol. A series of 21 IMPDH inhibitors were used to validate the docking procedure. Application of this procedure to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80d81ec3c6119cdfa502b3deb6ec0106
https://pubmed.ncbi.nlm.nih.gov/12729643
https://pubmed.ncbi.nlm.nih.gov/12729643
Autor:
Rosemary A. Melarange, David Nigel Hurst, Peter James Machin, Celia Shivdasani, Rachel M. Bradshaw, David T. Burden, Allison D. Fryer, Leslie C. Blaber
Publikováno v:
Journal of medicinal chemistry. 26(11)
A series of 4-substituted phenoxypropanolamines was prepared and examined for beta-adrenoceptor activity. Some of the compounds, especially the [4-[2-[[2-(4-fluorophenyl)ethyl] oxy]ethoxy]phenoxy]propanolamines (14, 15, and 24), showed potent beta 1-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6bd791f372c9c74b4df3d64844b78f9
https://pubmed.ncbi.nlm.nih.gov/6138435
https://pubmed.ncbi.nlm.nih.gov/6138435