Zobrazeno 1 - 10
of 513
pro vyhledávání: '"Nigel H Greig"'
Autor:
David Tweedie, Hanuma Kumar Karnati, Roger Mullins, Chaim G Pick, Barry J Hoffer, Edward J Goetzl, Dimitrios Kapogiannis, Nigel H Greig
Publikováno v:
eLife, Vol 9 (2020)
Traumatic brain injury (TBI) is a serious global health problem, many individuals live with TBI-related neurological dysfunction. A lack of biomarkers of TBI has impeded medication development. To identify new potential biomarkers, we time-dependentl
Externí odkaz:
https://doaj.org/article/a33459bcae204b97993da13e520fc0a6
Autor:
Chih-Tung Lin, Daniela Lecca, Ling-Yu Yang, Weiming Luo, Michael T Scerba, David Tweedie, Pen-Sen Huang, Yoo-Jin Jung, Dong Seok Kim, Chih-Hao Yang, Barry J Hoffer, Jia-Yi Wang, Nigel H Greig
Publikováno v:
eLife, Vol 9 (2020)
Traumatic brain injury (TBI) causes mortality and disability worldwide. It can initiate acute cell death followed by secondary injury induced by microglial activation, oxidative stress, inflammation and autophagy in brain tissue, resulting in cogniti
Externí odkaz:
https://doaj.org/article/3c2e1f55fd3a4ffd8982901f2fa50dfe
Autor:
Miguel A Pappolla, Laxmaiah Manchikanti, Clark R Andersen, Nigel H Greig, Fawad Ahmed, Xiang Fang, Michael A Seffinger, Andrea M Trescot
Publikováno v:
PLoS ONE, Vol 14, Iss 5, p e0216079 (2019)
Fibromyalgia (FM) is one of the most frequent generalized pain disorders with poorly understood neurobiological mechanisms. This condition accounts for an enormous proportion of healthcare costs. Despite extensive research, the etiology of FM is unkn
Externí odkaz:
https://doaj.org/article/e9030a0af14d43a8b1f05ac9add106f8
Publikováno v:
PLoS ONE, Vol 13, Iss 8, p e0201022 (2018)
Hyperbilirubinemia (jaundice) is caused by raised levels of unconjugated bilirubin in the blood. When severe, susceptible brain regions including the cerebellum and auditory brainstem are damaged causing neurological sequelae such as ataxia, hearing
Externí odkaz:
https://doaj.org/article/01f93a05337c4559b2141620377520d6
Autor:
Alicia Bedolla, Elliot Wegman, Max Weed, Messiyah K. Stevens, Kierra Ware, Aditi Paranjpe, Anastasia Alkhimovitch, Igal Ifergan, Aleksandr Taranov, Joshua D. Peter, Rosa Maria Salazar Gonzalez, J. Elliott Robinson, Lucas McClain, Krishna M. Roskin, Nigel H. Greig, Yu Luo
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-25 (2024)
Abstract While TGF-β signaling is essential for microglial function, the cellular source of TGF-β1 ligand and its spatial regulation remains unclear in the adult CNS. Our data supports that microglia but not astrocytes or neurons are the primary pr
Externí odkaz:
https://doaj.org/article/da033bed56594665960700b6c6a95a25
Autor:
Miaad Bader, Yazhou Li, Daniela Lecca, Vardit Rubovitch, David Tweedie, Elliot Glotfelty, Lital Rachmany, Hee Kyung Kim, Ho-Il Choi, Barry J. Hoffer, Chaim G. Pick, Nigel H. Greig, Dong Seok Kim
Publikováno v:
Neurobiology of Disease, Vol 199, Iss , Pp 106563- (2024)
Externí odkaz:
https://doaj.org/article/4a8fdaad6d87422b91427c0a069d7f0b
Autor:
David Tweedie, Koji Fukui, Yazhou Li, Qian-Sheng Yu, Shani Barak, Ian A Tamargo, Vardit Rubovitch, Harold W Holloway, Elin Lehrmann, William H Wood, Yongqing Zhang, Kevin G Becker, Evelyn Perez, Henriette Van Praag, Yu Luo, Barry J Hoffer, Robert E Becker, Chaim G Pick, Nigel H Greig
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0156493 (2016)
Traumatic brain injury (TBI), often caused by a concussive impact to the head, affects an estimated 1.7 million Americans annually. With no approved drugs, its pharmacological treatment represents a significant and currently unmet medical need. In ou
Externí odkaz:
https://doaj.org/article/afeb8f2d25b74059bdb714ab09610d3b
Autor:
Vicki Wang, Kuan-Yin Tseng, Tung-Tai Kuo, Eagle Yi-Kung Huang, Kuo-Lun Lan, Zi-Rong Chen, Kuo-Hsing Ma, Nigel H. Greig, Jin Jung, Ho-II Choi, Lars Olson, Barry J. Hoffer, Yuan-Hao Chen
Publikováno v:
Journal of Biomedical Science, Vol 31, Iss 1, Pp 1-19 (2024)
Abstract Background Mitochondria are essential organelles involved in cellular energy production. Changes in mitochondrial function can lead to dysfunction and cell death in aging and age-related disorders. Recent research suggests that mitochondrial
Externí odkaz:
https://doaj.org/article/42e9f0f96ce54c0abdd8d29f68afa314
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-20 (2024)
Abstract Depression negatively impacts mood, behavior, and mental and physical health. It is the third leading cause of suicides worldwide and leads to decreased quality of life. We examined 18 genes available at the genetic testing registry (GTR) fr
Externí odkaz:
https://doaj.org/article/d7c4864a1af0488f8d11054c7c0feed3
Autor:
Jun Chen, Hongna Pan, Cynthia Chen, Wei Wu, Kevin Iskandar, Jeffrey He, Tetsade Piermartiri, David M Jacobowitz, Qian-Sheng Yu, John H McDonough, Nigel H Greig, Ann M Marini
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e99818 (2014)
Organophosphorus (OP) nerve agents are deadly chemical weapons that pose an alarming threat to military and civilian populations. The irreversible inhibition of the critical cholinergic degradative enzyme acetylcholinesterase (AChE) by OP nerve agent
Externí odkaz:
https://doaj.org/article/f1f566335cc54844a09602afaeb064ba