Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Nigel Gensmantel"'
Autor:
Stephen Connolly, Antonio Mete, Glen Andrews, Nigel Gensmantel, Gunilla Andersson, Matt D. Kroeger, Andrew S. Arvai, Peter Hamley, Stephen A. St-Gallay, Brian R. Crane, Elizabeth D. Getzoff, Alan V. Wallace, Anders Åberg, Robin J. Rosenfeld, Philip Mallinder, David J. Nicholls, John A. Tainer, Dennis J. Stuehr, Elsa D. Garcin, Tinker Alan, David Cheshire
Publikováno v:
Nature chemical biology
Nitric oxide synthase (NOS) enzymes synthesize nitric oxide, a signal for vasodilatation and neurotransmission at low concentrations and a defensive cytotoxin at higher concentrations. The high active site conservation among all three NOS isozymes hi
Autor:
Pilar Prieto, Nigel Gensmantel, W. Steiling, Walter Pfaller, Peter Hoet, David E. Leahy, Vera Rogiers, M. Monshouwer, Bas J. Blaauboer, Andreas P. Freidig, Bernhard Ladstetter, Benoit Nemery, Greetje Elaut, Enrico Sabbioni, Johannes J.M. van de Sandt, Stuart J. Freeman, Nick Proctor, Annarita Meneguz, Geert Mannens, Sandra Coecke, Olavi Pelkonen, Vassilios M Kapoulas, Gill Langley, Amin Rostami-Hodjegan
Publikováno v:
Alternatives to Laboratory Animals. 33:147-175
Autor:
Darren R. Flower, D Cox, R G Humphries, N P Tomkinson, A.H. Ingall, P A Cage, Nigel Gensmantel, D P Marriott, Andrew M. Davis, N.D. Kindon
Publikováno v:
Journal of Pharmacy and Pharmacology. 48:206-209
FPL67085MX represents the first in a class of novel, highly potent and selective P2T purinoceptor antagonists which are inhibitors of adenosine diphosphate (ADP)-induced platelet aggregation in-vitro. In an early series of compounds we studied the ef
Autor:
Stephen Connolly, Nigel Gensmantel, Peter Hamley, Richard P. Harrison, Paul Hartopp, Nigel Boughton-Smith, Timothy Nicholas Birkinshaw, Antonio Mete, Haydn Beaton, Sally L. Cooper, Austen Pimm, David Cheshire, Gunilla Andersson, Alan V. Wallace, Anders Åberg, Paul D. Leeson, John Dixon, David Cox, Timothy Jon Luker, Helena Käck, Ian Millichip, Steve St-Gallay, David J. Nicholls, Anne Cooper, Glen Andrews, Tony R. Cook
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(8)
By careful analysis of experimental X-ray ligand crystallographic protein data across several inhibitor series we have discovered a novel, potent and selective series of iNOS inhibitors exemplified by compound 8.
Autor:
Darren V. S. Green, Ian H. Hillier, Gareth A. Morris, David Hulme Robinson, Nigel Gensmantel, David W. Payling
Publikováno v:
Journal of Molecular Structure: THEOCHEM. 251:173-193
The conformational isomerism in a series of molecules related to inhibitors of the angiotensinconverting enzyme (ACE) is investigated using the semiempirical quantum mechanical molecular orbital model, AM1, and dynamic NMR spectroscopy. The theoretic
Publikováno v:
J. Chem. Soc., Perkin Trans. 2. :2025-2032
A combined ab initio molecular orbital–molecular mechanical computational model has been applied to the investigation of the potential energy surface of catalysis by the enzyme phosphoiipase A2. By the integration of molecular mechanical and quantu
Autor:
Sandra Coecke, Blaauboer, Bas J., Greetje Elaut, Stuart Freeman, Andreas Freidig, Nigel Gensmantel, Peter Hoet, Kapoulas, Vassilios M., Bernhard Ladstetter, Gill Langley, David Leahy, Geert Mannens, Annarita Meneguz, Mario Monshouwer, Nemery, B., Olavi Pelkonen, Walter Pfaller, Pilar Prieto, Nick Proctor, Vera Rogiers, Amin Rostami-Hodjegan, Enrico Sabbioni, Winfried Steiling, Sandt, Johannes J. M.
Publikováno v:
Scopus-Elsevier
Vrije Universiteit Brussel
ATLA Alternatives to Laboratory Animals, SUPPL. 1, 33, 147-175
Vrije Universiteit Brussel
ATLA Alternatives to Laboratory Animals, SUPPL. 1, 33, 147-175
Autor:
Barbara Hitchin, Catherine Hallam, Clive G. Jackson, Colin Bennion, David Hulme Robinson, Haydn G. Beaton, Anthony Ronald Cook, Nigel Gensmantel, Kim Hardy, Stephen Connolly
Publikováno v:
Journal of Medicinal Chemistry. 37:557-559
Publikováno v:
Journal of medicinal chemistry. 37(7)
The use of GRID in the 3-D QSAR analysis of a series of calcium-channel agonists is described. Partial least-squares analysis of GRID maps showing the interaction energy between an alkyl hydroxyl probe and a series of agonists in 3-D space generated
Publikováno v:
Trends in QSAR and Molecular Modelling 92 ISBN: 9789072199133
Trends in QSAR and Molecular Modelling 92
Trends in QSAR and Molecular Modelling 92
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c86798466299939511b094e1f1ace600
https://doi.org/10.1007/978-94-011-1472-1_139
https://doi.org/10.1007/978-94-011-1472-1_139