Zobrazeno 1 - 10
of 128
pro vyhledávání: '"Nigel G. J. Richards"'
Publikováno v:
Frontiers in Chemical Biology, Vol 3 (2024)
Remarkable progress has been made to elucidate the structural and mechanistic enzymology of the biosynthetic pathways that give rise to naturally occurring C-nucleosides. These compounds are generally cytotoxic and exhibit interesting antiviral, anti
Externí odkaz:
https://doaj.org/article/1748ac8446a54b6684e682150a37a2c0
Autor:
Wenbo Li, Georgina C. Girt, Ashish Radadiya, James J. P. Stewart, Nigel G. J. Richards, James H. Naismith
Publikováno v:
Open Biology, Vol 13, Iss 1 (2023)
The biosynthetic enzyme, ForT, catalyses the formation of a C-C bond between 4-amino-1H-pyrazoledicarboxylic acid and MgPRPP to produce a C-nucleoside precursor of formycin A. The transformation catalysed by ForT is of chemical interest because it is
Externí odkaz:
https://doaj.org/article/b467e3be81bb497c80e826477a1d7050
Autor:
Adriana Coricello, Wen Zhu, Antonio Lupia, Carmen Gratteri, Matthijn Vos, Vincent Chaptal, Stefano Alcaro, Yuichiro Takagi, Nigel G. J. Richards
Publikováno v:
bioRxiv
How dynamical motions in enzymes might be linked to catalytic function is of significant general interest, although almost all relevant experimental data, to date, has been obtained for enzymes with a single active site. Recent advances in X-ray crys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb568495f9be2505bc3798e148da6bea
https://europepmc.org/articles/PMC10245805/
https://europepmc.org/articles/PMC10245805/
Publikováno v:
Philosophical Transactions of the Royal Society B: Biological Sciences. 378
Physical organic chemistry and mechanistic thinking provide a strong intellectual framework for understanding the chemical logic of evolvable informational macromolecules and metabolic transformations in living organisms. These concepts have also led
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb72d292b5fcbc12ab4ad27ce13b228a
https://doi.org/10.1098/rstb.2022.0023
https://doi.org/10.1098/rstb.2022.0023
Autor:
null Wenbo Li, null Georgina C. Girt, null Ashish Radadiya, null James J. P. Stewart, null Nigel G. J. Richards, null James H. Naismith
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::223fa106545dad3cc891aa7502328644
https://doi.org/10.1098/rsob.220287/v2/response1
https://doi.org/10.1098/rsob.220287/v2/response1
Publikováno v:
The Journal of Biological Chemistry
DNA polymerases are today used throughout scientific research, biotechnology, and medicine, in part for their ability to interact with unnatural forms of DNA created by synthetic biologists. Here especially, natural DNA polymerases often do not have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35ac08dee4cd2fbcbcb08bf7483a6200
https://doi.org/10.1074/jbc.rev120.013745
https://doi.org/10.1074/jbc.rev120.013745
Autor:
Sabera Bijani, Faraz Shaikh, Sheefa Mirza, Shirley Weng In Siu, Nayan Jain, Rakesh Rawal, Nigel G. J. Richards, Anamik Shah, Ashish Radadiya
P-glycoprotein (Pgp), an ATP binding cassette (ABC) transporter, is an ATP-dependent efflux pump responsible for cancer multidrug resistance. As part of efforts to identify human Pgp (hPgp) inhibitors, we prepared a series of novel triazole-conjugate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cac209496f1ca9817bb13382fda68d4e
https://orca.cardiff.ac.uk/id/eprint/149517/1/acsomega.1c05839.pdf
https://orca.cardiff.ac.uk/id/eprint/149517/1/acsomega.1c05839.pdf
Publikováno v:
Biochemistry
[Image: see text] l-Asparaginase (EC 3.5.1.1) was first used as a component of combination drug therapies to treat acute lymphoblastic leukemia (ALL), a cancer of the blood and bone marrow, almost 50 years ago. Administering this enzyme to reduce asp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03dc4d9e1f53ac30116271c82e48cec0
https://doi.org/10.1021/acs.biochem.0c00354
https://doi.org/10.1021/acs.biochem.0c00354
Autor:
Frank M. Raushel, Tamari Narindoshvili, Alexander S. Riegert, Nigel G. J. Richards, Adriana Coricello
Publikováno v:
Biochemistry
Campylobacter jejuni is a Gram-negative, pathogenic bacterium that causes campylobacteriosis, a form of gastroenteritis. C. jejuni is the most frequent cause of food-borne illness in the world, surpassing Salmonella and E. coli. Coating the surface o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcef06f8f9f749e6c0e46d1fcf04b67b
https://orca.cardiff.ac.uk/id/eprint/144911/1/PP.pdf
https://orca.cardiff.ac.uk/id/eprint/144911/1/PP.pdf
Autor:
Tsuyoshi Imasaki, Patrick Baumann, Claudine Bisson, Ashish Radadiya, Yuichiro Takagi, David W. Rice, Svetlana E. Sedelnikova, Nigel G. J. Richards, Adriana Coricello, Tyzoon K. Nomanbhoy, Alexandria H. Berry, Sabine Wenzel, John W. Kozarich, Yi Jin, Brian E. Nordin, Wen Zhu, Francisco Martínez-Márquez
Publikováno v:
Communications Biology, Vol 2, Iss 1, Pp 1-14 (2019)
Communications Biology
Communications Biology
Expression of human asparagine synthetase (ASNS) promotes metastatic progression and tumor cell invasiveness in colorectal and breast cancer, presumably by altering cellular levels of L-asparagine. Human ASNS is therefore emerging as a bona fide drug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6b6e17ac46e2600532640cbb5658656
http://link.springer.com/article/10.1038/s42003-019-0587-z
http://link.springer.com/article/10.1038/s42003-019-0587-z