Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Nigel D. Stow"'
Autor:
Renata Szczepaniak, Brandon S. Albright, Elizabeth A. Cook, James F. Conway, Sandra K. Weller, Nigel D. Stow, Athena Kosinski
Publikováno v:
Journal of Virology. 89:443-453
During DNA encapsidation, herpes simplex virus 1 (HSV-1) procapsids are converted to DNA-containing capsids by a process involving activation of the viral protease, expulsion of the scaffold proteins, and the uptake of viral DNA. Encapsidation requir
Autor:
Jill Murray, Mary C. Murphy, Maureen O'Hara, Frazer J. Rixon, Valerie G. Preston, Nigel D. Stow
Publikováno v:
Journal of Virology. 84:4252-4263
The herpes simplex virus type 1 (HSV-1) UL25 gene encodes a minor capsid protein, pUL25, that is essential for packaging the full-length viral genome. Six regions which contain disordered residues have been identified in the high-resolution structure
Autor:
Lily Tong, Nigel D. Stow
Publikováno v:
Journal of Virology. 84:321-329
The minimal signal required for the cleavage and packaging of replicated concatemeric herpes simplex virus type 1 (HSV-1) DNA corresponds to an approximately 200-bp fragment, Uc-DR1-Ub, spanning the junction of the genomic L and S segments. Uc and Ub
Publikováno v:
Journal of Virology. 80:2118-2126
Herpes simplex virus type 1 packages its DNA genome into a precursor capsid, referred to as the procapsid. Of the three capsid-associated DNA-packaging proteins, UL17, UL25, and UL6, only UL17 and UL6 appear to be components of the procapsid, with UL
Autor:
Andrew J. Davison, Nigel D. Stow
Publikováno v:
Journal of Virology. 79:12880-12892
Published work (D. J. McGeoch, Nucleic Acids Res. 18: 4105-4110, 1990; J. E. McGeehan, N. W. Depledge, and D. J. McGeoch, Curr. Protein Peptide Sci. 2: 325-333, 2001) has indicated that evolution of dUTPase in the class of herpesviruses that infect m
Autor:
Nigel D. Stow, Blair L. Strang
Publikováno v:
Journal of Virology. 79:12487-12494
For many years, the generally accepted model for the replication of the double-stranded DNA genome of herpes simplex virus type 1 (HSV-1) incorporated initial circularization of linear molecules in the cell nucleus. Ensuing DNA synthesis resulted in
Autor:
Iain M. Porter, Nigel D. Stow
Publikováno v:
Journal of General Virology. 85:583-591
Open reading frame UL12 of herpes simplex virus type 1 (HSV-1) encodes an alkaline nuclease that has previously been implicated in processing the complex, branched, viral DNA replication intermediates and allowing egress of DNA-containing capsids fro
Publikováno v:
Journal of General Virology. 84:639-645
Human cytomegalovirus (HCMV) displays an exceptionally restricted host range in tissue culture with human fibroblasts being the principal fully permissive system. Nevertheless, immediate early (IE) proteins are expressed following infection of many n
Publikováno v:
Antiviral Research. 56:1-11
Evolutionary studies have a large theoretical component and will not directly provide therapies for herpesvirus infections. However, they do provide a conceptual framework within which we can evaluate the origins of the various systems that contribut
Autor:
Nigel D. Stow
Publikováno v:
Journal of Virology. 75:10755-10765
The herpes simplex virus type 1 (HSV-1) mutant KUL25NS, containing a null mutation within the UL25 gene, was isolated and characterized by McNab and coworkers (A. R. McNab, P. Desai, S. Person, L. L. Roof, D. R. Thomsen, W. W. Newcomb, J. C. Brown, a