Zobrazeno 1 - 10
of 106
pro vyhledávání: '"Nigel D. F. Grindley"'
Publikováno v:
Biotechnology & Biological Frontiers ISBN: 9780429050329
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d6f4c6fc279c451de4c5f47eb0b93694
https://doi.org/10.4324/9780429050329-29
https://doi.org/10.4324/9780429050329-29
Publikováno v:
Nucleic Acids Research
DNA segment exchange by site-specific serine recombinases (SRs) is thought to proceed by rigid-body rotation of the two halves of the synaptic complex, following the cleavages that create the two pairs of exchangeable ends. It remains unresolved how
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17d9664be3efd71ef2646bb31545da5f
http://europepmc.org/articles/PMC5062993
http://europepmc.org/articles/PMC5062993
Publikováno v:
Journal of Biological Chemistry. 286:3755-3766
DNA polymerases catalyze the incorporation of deoxynucleoside triphosphates into a growing DNA chain using a pair of Mg(2+) ions, coordinated at the active site by two invariant aspartates, whose removal by mutation typically reduces the polymerase a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68d90f9559e1a80b4cfa8de7eb2e9a51
https://doi.org/10.1074/jbc.m110.167593
https://doi.org/10.1074/jbc.m110.167593
Autor:
Nigel D. F. Grindley
Publikováno v:
Mobile DNA II. :272-302
This chapter discusses the organization of Tn3-family transposons and their transposition (the formation and resolution of the cointegrate intermediate). The bulk of the chapter, however, is concerned with the process of cointegrate resolution as per
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8d84f8cd6e1800ae61ed0e988d6495a
https://doi.org/10.1128/9781555817954.ch14
https://doi.org/10.1128/9781555817954.ch14
Autor:
Santanov Chaudhuri, Olga Potapova, Angela M. DeLucia, Nigel D. F. Grindley, Catherine M. Joyce
Publikováno v:
Journal of Biological Chemistry. 281:27286-27291
Y-family (lesion-bypass) DNA polymerases show the same overall structural features seen in other members of the polymerase superfamily, yet their active sites are more open, with fewer contacts to the DNA and nucleotide substrates. This raises the qu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ae4599b89be2fc9daa25e5fdd461728
https://doi.org/10.1074/jbc.m604393200
https://doi.org/10.1074/jbc.m604393200
Autor:
Angela M. DeLucia, Nigel D. F. Grindley, Sandra A. Helquist, Chikio Chan, Catherine M. Joyce, Olga Potapova, Eric T. Kool
Publikováno v:
Biochemistry. 45:890-898
We report the first pre-steady-state kinetic studies of DNA replication in the absence of hydrogen bonds. We have used nonpolar nucleotide analogues that mimic the shape of a Watson-Crick base pair to investigate the kinetic consequences of a lack of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3aa650652cdd5265ec733341707004e5
https://doi.org/10.1021/bi051792i
https://doi.org/10.1021/bi051792i
Autor:
Gary J. Sarkis, Weikai Li, Satwik Kamtekar, Nigel D. F. Grindley, Yong Xiong, Thomas A. Steitz
Publikováno v:
Science. 309:1210-1215
The structure of a synaptic intermediate of the site-specific recombinase γδ resolvase covalently linked through Ser 10 to two cleaved duplex DNAs has been determined at 3.4 angstrom resolution. This resolvase, activated for recombination by mutati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4008bca5692fba2f152177f729e6a0be
https://doi.org/10.1126/science.1112064
https://doi.org/10.1126/science.1112064
Publikováno v:
Journal of Bacteriology. 186:858-865
Cut-and-paste (simple insertion) and replicative transposition pathways are the two classical paradigms by which transposable elements are mobilized. A novel variation of cut and paste, a two-step transposition cycle, has recently been proposed for i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2797fcb90231d71ff6a586a46ff2307
https://doi.org/10.1128/jb.186.3.858-865.2004
https://doi.org/10.1128/jb.186.3.858-865.2004
Publikováno v:
Molecular Cell. 12:775-781
Activated mutants of the serine recombinase, gammadelta resolvase, form a simplified recombinogenic synaptic complex containing a tetramer of resolvase and two crossover sites. We have probed the architecture of this complex by measuring the efficien
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc65e63dfb6edab83e3f75c0abbf0cd1
https://doi.org/10.1016/s1097-2765(03)00351-4
https://doi.org/10.1016/s1097-2765(03)00351-4