Výsledky vyhledávání - "Nigel D L Savage"

Akademický článek

A high-throughput screen for tuberculosis progression.

Autor: Ralph Carvalho, Jan de Sonneville, Oliver W Stockhammer, Nigel D L Savage, Wouter J Veneman, Tom H M Ottenhoff, Ron P Dirks, Annemarie H Meijer, Herman P Spaink

Publikováno v: PLoS ONE, Vol 6, Iss 2, p e16779 (2011)

One-third of the world population is infected with Mycobacterium tuberculosis and multi-drug resistant strains are rapidly evolving. The noticeable absence of a whole organism high-throughput screening system for studying the progression of tuberculo

Externí odkaz: https://doaj.org/article/f48d3188535341409455dd502ae3be14

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Akademický článek

Mycobacterium tuberculosis peptides presented by HLA-E molecules are targets for human CD8 T-cells with cytotoxic as well as regulatory activity.

Autor: Simone A Joosten, Krista E van Meijgaarden, Pascale C van Weeren, Fatima Kazi, Annemieke Geluk, Nigel D L Savage, Jan W Drijfhout, Darren R Flower, Willem A Hanekom, Michèl R Klein, Tom H M Ottenhoff

Publikováno v: PLoS Pathogens, Vol 6, Iss 2, p e1000782 (2010)

Tuberculosis (TB) is an escalating global health problem and improved vaccines against TB are urgently needed. HLA-E restricted responses may be of interest for vaccine development since HLA-E displays very limited polymorphism (only 2 coding variant

Externí odkaz: https://doaj.org/article/7131a35e2dd241dda2087c4d374e973e

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Akademický článek

Gravitational effects on fibroblasts’ function in relation to wound healing

Autor: Wilhelmina E. Radstake, Kiran Gautam, Silvana Miranda, Cynthia Van Rompay, Randy Vermeesen, Kevin Tabury, Mieke Verslegers, Alan Dowson, Jeffrey Gorissen, Jack J. W. A. van Loon, Nigel D. L. Savage, Sarah Baatout, Bjorn Baselet

Publikováno v: npj Microgravity, Vol 9, Iss 1, Pp 1-11 (2023)

Abstract The spaceflight environment imposes risks for maintaining a healthy skin function as the observed delayed wound healing can contribute to increased risks of infection. To counteract delayed wound healing in space, a better understanding of t

Externí odkaz: https://doaj.org/article/6ebf281ea3424629a1a9f401beedf4e0

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Combined chemical genetics and data-driven bioinformatics approach identifies receptor tyrosine kinase inhibitors as host-directed antimicrobials

Autor: Omid Rabiee, Mariëlle C. Haks, Cornelis J. Korbee, Dragi Kocev, Matthias T. Heemskerk, Louis Wilson, Tom H. M. Ottenhoff, Elisabeth van Strijen, Nigel D. L. Savage, Kees L. M. C. Franken, Sašo Džeroski

Publikováno v: Nature Communications
Nature Communications, 9
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)

Antibiotic resistance poses rapidly increasing global problems in combatting multidrug-resistant (MDR) infectious diseases like MDR tuberculosis, prompting for novel approaches including host-directed therapies (HDT). Intracellular pathogens like Sal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a07ecc96213ed76a283458db2d838392

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IFN-α cannot substitute lack of IFN-γ responsiveness in cells of an IFN-γR1 deficient patient

Autor: Jaap T. van Dissel, Nigel D. L. Savage, Esther van de Vosse, Annelies van Wengen, Diederik van de Wetering

Publikováno v: Clinical Immunology. 138:282-290

Patients with complete IFN-γR deficiency are unable to respond to IFN-γ and have impaired Th1-immunity and recurrent, severe infections with weakly virulent Mycobacteria. Since IFN-α and IFN-γ share signalling pathways, treatment with IFN-α has

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c623c8b9f3730df76398d243cb91639e
https://doi.org/10.1016/j.clim.2010.12.005

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Induction of regulatory T cells by macrophages is dependent on production of reactive oxygen species

Autor: Tom H. M. Ottenhoff, Marina D. Kraaij, Kyra A. Gelderman, Rikard Holmdahl, Nigel D. L. Savage, Jun Wang, Karin Koekkoek, Sandra W. van der Kooij, Cees van Kooten, J. Merlijn van den Berg, Taco W. Kuijpers

Publikováno v: Proceedings of the National Academy of Sciences; Vol 107
Proceedings of the National Academy of Sciences
Proceedings of the National Academy of Sciences, 107(41), 17686-17691
Proceedings of the National Academy of Sciences of the United States of America, 107(41), 17686-17691. National Academy of Sciences

The phagocyte NAPDH–oxidase complex consists of several phagocyte oxidase ( phox) proteins, generating reactive oxygen species (ROS) upon activation. ROS are involved in the defense against microorganisms and also in immune regulation. Defective RO

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42dca7f0f99f9ee6936eea97d19a537d
https://doi.org/10.1073/pnas.1012016107

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Transcriptional and inflammasome-mediated pathways for the induction of IL-1β production byMycobacterium tuberculosis

Autor: Bart Jan Kullberg, Reinout van Crevel, Charles A. Dinarello, André J. A. M. van der Ven, Leo A. B. Joosten, Frank L. van de Veerdonk, Johanneke Kleinnijenhuis, Jos W. M. van der Meer, Mihai G. Netea, Nigel D. L. Savage, Tom H. M. Ottenhoff

Publikováno v: European Journal of Immunology. 39:1914-1922

Proinflammatory cytokines of the IL-1 family play an important role for the anti-mycobacterial host defense mechanisms. In the present study we have deciphered the pathways leading from recognition of Mycobacterium tuberculosis to the production and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::77afa62b39f67705a52abdbf73a0ab0c
https://doi.org/10.1002/eji.200839115

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Inhibition of TCR-mediated shedding of L-selectin (CD62L) on human and mouse CD4+ T cells by metalloproteinase inhibition: analysis of the regulation of Th1/Th2 function

Autor: Jonathan R. Lamb, Nigel D. L. Savage, Guy T. Layton, Bernadette De Silva, Sarah E. M. Howie, Adriano G. Rossi, Stephen H. Harris

Publikováno v: European Journal of Immunology. 32:2905-2914

The generation of a productive primary immune response is dependent on the ability of naive T lymphocytes to recirculate through peripheral lymph organs to encounter specific antigen. The process of naive CD4 + T cell entry into lymph nodes correlate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6010bf7b8c694fb14c395a318b1372b8
https://doi.org/10.1002/1521-4141(2002010)32:10<2905::aid-immu2905>3.0.co

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Janus -faced liposomes enhance antimicrobial innate immune response in Mycobacterium tuberculosis infection

Publikováno v: Proceedings of the National Academy of Sciences
Proceedings of the National Academy of Sciences, 109(21), E1360-E1368
Proceedings of the National Academy of Sciences; Vol 109

We have generated unique asymmetric liposomes with phosphatidylserine (PS) distributed at the outer membrane surface to resemble apoptotic bodies and phosphatidic acid (PA) at the inner layer as a strategy to enhance innate antimycobacterial activity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c85ddfebc4768b0c66f6abcdae9ec190
http://hdl.handle.net/10447/73214

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Mycobacterial secretion systems ESX-1 and ESX-5 play distinct roles in host cell death and inflammasome activation

Autor: Cees J. Korbee, Louis Wilson, Karin de Punder, Jovanka Bestebroer, Peter J. Peters, Maaike van Zon, Wilbert Bitter, Tom H. M. Ottenhoff, Abdallah M. Abdallah, Nigel D. L. Savage, Astrid M. van der Sar, Nicole N. van der Wel

Publikováno v: Journal of immunology (Baltimore, Md., 187(9), 4744-4753. American Association of Immunologists
The Journal of Immunology
The Journal of Immunology; Vol 187
Journal of Immunology, 187(9), 4744-4753. American Association of Immunologists
Abdallah, A M, Bestebroer, J, Savage, N D L, de Punder, K, van Zon, M, Wilson, L, Korbee, C J, van der Sar, A M, Ottenhoff, T H M, van der Wel, N N, Bitter, W & Peters, P J 2011, ' Mycobacterial Secretion Systems ESX-1 and ESX-5 Play Distinct Roles in Host Cell Death and Inflammasome Activation ', Journal of Immunology, vol. 187, no. 9, pp. 4744-4753 . https://doi.org/10.4049/jimmunol.1101457
Journal of Immunology, 187(9), 4744-53
Journal of Immunology, 187(9), 4744-4753

During infection of humans and animals, pathogenic mycobacteria manipulate the host cell causing severe diseases such as tuberculosis and leprosy. To understand the basis of mycobacterial pathogenicity, it is crucial to identify the molecular virulen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5462811c67d107f166d61d8bc038b0f5
https://pubmed.ncbi.nlm.nih.gov/21957139

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