Zobrazeno 1 - 10
of 179
pro vyhledávání: '"Nigel C. Jones"'
Autor:
Mohit Javalgekar, Bianca Jupp, Lucy Vivash, Terence J. O’Brien, David K. Wright, Nigel C. Jones, Idrish Ali
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-15 (2024)
Abstract Post-traumatic epilepsy (PTE) is one of the most debilitating consequences of traumatic brain injury (TBI) and is one of the most drug-resistant forms of epilepsy. Novel therapeutic treatment options are an urgent unmet clinical need. The cu
Externí odkaz:
https://doaj.org/article/298b2c2ffd18480d9b0f4ca1d5b70ca0
Autor:
Zining Liu, Peravina Thergarajan, Ana Antonic‐Baker, Zhibin Chen, Paul B. Sparks, Natasha A. Lannin, Patrick Kwan, Nigel C. Jones, Pablo M. Casillas‐Espinosa, Piero Perucca, Terence J. O'Brien, Shobi Sivathamboo
Publikováno v:
Epilepsia Open, Vol 8, Iss 1, Pp 46-59 (2023)
Abstract Objective Epilepsy is associated with an increased risk of cardiovascular disease and mortality. Whether cardiac structure and function are altered in epilepsy remains unclear. To address this, we conducted a systematic review and meta‐ana
Externí odkaz:
https://doaj.org/article/41d28ae52732432281edd50736966a1d
Autor:
Xueying Li, Wanhua Qiu, Lu Deng, Jingjing Lin, Wenting Huang, Yuchen Xu, Mulan Zhang, Nigel C. Jones, Runxuan Lin, Huiqin Xu, Li Lin, Peijun Li, Xinshi Wang
Publikováno v:
Journal of Translational Medicine, Vol 20, Iss 1, Pp 1-13 (2022)
Abstract Background Glucocorticoid signalling is closely related to both epilepsy and associated cognitive impairment, possibly through mechanisms involving neuronal apoptosis. As a critical enzyme for glucocorticoid action, the role of 11β-hydroxys
Externí odkaz:
https://doaj.org/article/0b136d42cbb548fca16bcbf087fa8ab5
Autor:
Peravina Thergarajan, Matthew R. Hudson, Irena Carmichael, Jérôme Clasadonte, Stefanie Dedeurwaerdere, Terence J. O'Brien, Nigel C. Jones, Idrish Ali
Publikováno v:
Neurobiology of Disease, Vol 168, Iss , Pp 105688- (2022)
Objective: Status epilepticus (SE) models in rodents are commonly used to research mesial temporal lobe epilepsy (mTLE) in translational epilepsy research. However, due to differences in susceptibility of mice strains to chemoconvulsants, developing
Externí odkaz:
https://doaj.org/article/abcb5420f3094f8bbe958023e5e92057
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
Background: There is increased prevalence of epilepsy in patients with Alzheimer’s disease (AD). Although shared pathological and clinical features have been identified, the underlying pathophysiology and cause-effect relationships are poorly under
Externí odkaz:
https://doaj.org/article/75d4a315ae5a4a7ca0986b6ae1f6623c
Autor:
Kim L. Powell, Zining Liu, Claire L. Curl, Antonia J.A. Raaijmakers, Pragati Sharma, Emma L. Braine, Flavia M. Gomes, Shobi Sivathamboo, Vaughan G. Macefield, Pablo M. Casillas-Espinosa, Nigel C. Jones, Lea M. Delbridge, Terence J. O’Brien
Publikováno v:
Neurobiology of Disease, Vol 159, Iss , Pp 105505- (2021)
Objective: This study aimed to prospectively examine cardiac structure and function in the kainic acid-induced post-status epilepticus (post-KA SE) model of chronic acquired temporal lobe epilepsy (TLE), specifically to examine for changes between th
Externí odkaz:
https://doaj.org/article/2f278a222be74d4a903bacd65e7a477e
Autor:
Matthew R. Hudson, Joshua Foreman, Gil Rind, Elizabeth E. Manning, Nigel C. Jones, Maarten van den Buuse
Publikováno v:
Brain Sciences, Vol 12, Iss 11, p 1503 (2022)
Dysregulation of high-frequency neuronal oscillations has been implicated in the pathophysiology of schizophrenia. Chronic methamphetamine (METH) use can induce psychosis similar to paranoid schizophrenia. The current study in mice aimed to determine
Externí odkaz:
https://doaj.org/article/d25ef894f58a446b985a079bc396f46d
Autor:
Naomi Dvir, Muhammad S. Javaid, Nigel C. Jones, Kim L. Powell, Patrick Kwan, Terence J. O’Brien, Ana Antonic-Baker
Publikováno v:
Systematic Reviews, Vol 8, Iss 1, Pp 1-4 (2019)
Abstract Background Epilepsy is one of the most common and serious brain conditions, characterised by recurrent unprovoked seizures. It affects about 1% of the population worldwide. Despite a range of antiepileptic drugs being available, one third of
Externí odkaz:
https://doaj.org/article/d1df177300e94015a2c948431d15079f
Publikováno v:
Neurobiology of Disease, Vol 123, Iss , Pp 27-41 (2019)
Survivors of traumatic brain injury (TBI) often develop chronic neurological, neurocognitive, psychological, and psychosocial deficits that can have a profound impact on an individual’s wellbeing and quality of life. TBI is also a common cause of a
Externí odkaz:
https://doaj.org/article/6df032c8a3324d6fbe20996665a58f15
Autor:
Idrish Ali, Juliana C. Silva, Shijie Liu, Sandy R. Shultz, Patrick Kwan, Nigel C. Jones, Terence J. O'Brien
Publikováno v:
Neurobiology of Disease, Vol 123, Iss , Pp 100-109 (2019)
In the quest for developing new therapeutic targets for post-traumatic epilepsies (PTE), identifying mechanisms relevant to development and progression of disease is critical. A growing body of literature suggests involvement of neurodegenerative mec
Externí odkaz:
https://doaj.org/article/0a15790d4862444da8e3288a0d2a3a7c