Zobrazeno 1 - 10
of 195
pro vyhledávání: '"Nigel A. Calcutt"'
Autor:
Chaitanya K. Gavini, Nadia Elshareif, Gregory Aubert, Anand V. Germanwala, Nigel A. Calcutt, Virginie Mansuy-Aubert
Publikováno v:
Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-14 (2022)
Abstract Background Peripheral neuropathy is a common and progressive disorder in the elderly that interferes with daily activities. It is of importance to find efficient treatments to treat or delay this age-related neurodegeneration. Silencing macr
Externí odkaz:
https://doaj.org/article/91929b57cb8741daa50a9e577295d26d
Publikováno v:
Frontiers in Neurology, Vol 12 (2021)
HIV-associated distal sensory polyneuropathy (HIV-DSP) affects about one third of people with HIV and is characterized by distal degeneration of axons. The pathogenesis of HIV-DSP is not known and there is currently no FDA-approved treatment. HIV tra
Externí odkaz:
https://doaj.org/article/250f64692be744eea19101f3ebf3bd1b
Autor:
Mohamad-Reza Aghanoori, Darrell R. Smith, Shiva Shariati-Ievari, Andrew Ajisebutu, Annee Nguyen, Fiona Desmond, Carlos H.A. Jesus, Xiajun Zhou, Nigel A. Calcutt, Michel Aliani, Paul Fernyhough
Publikováno v:
Molecular Metabolism, Vol 20, Iss , Pp 149-165 (2019)
Objective: Diabetic sensorimotor polyneuropathy (DSPN) affects approximately half of diabetic patients leading to significant morbidity. There is impaired neurotrophic growth factor signaling, AMP-activated protein kinase (AMPK) activity and mitochon
Externí odkaz:
https://doaj.org/article/980266605466405092ed65f2ec8b79db
Autor:
Corinne G. Jolivalt, May Madi Han, Annee Nguyen, Fiona Desmond, Carlos Henrique Alves Jesus, Daniela C. Vasconselos, Andrea Pedneault, Natalie Sandlin, Sage Dunne-Cerami, Katie E. Frizzi, Nigel A. Calcutt
Publikováno v:
Journal of Clinical Medicine, Vol 11, Iss 9, p 2307 (2022)
Corneal confocal microscopy (CCM) is emerging as a tool for identifying small fiber neuropathy in both peripheral neuropathies and neurodegenerative disease of the central nervous system (CNS). The value of corneal nerves as biomarkers for efficacy o
Externí odkaz:
https://doaj.org/article/91e679d3f0dc44f3ae639298a532433a
Publikováno v:
Diabetes & Metabolism Journal, Vol 45, Iss 3, Pp 457-458 (2021)
Externí odkaz:
https://doaj.org/article/09443729c6c84df6957fec2f5009e87a
Autor:
Anne Worthington, Alise Kalteniece, Maryam Ferdousi, Luca D’Onofrio, Shaishav Dhage, Shazli Azmi, Clare Adamson, Shaheen Hamdy, Rayaz A. Malik, Nigel A. Calcutt, Andrew G. Marshall
Publikováno v:
Diagnostics, Vol 11, Iss 7, p 1247 (2021)
Impaired rate-dependent depression of the Hoffman reflex (HRDD) is a potential biomarker of impaired spinal inhibition in patients with painful diabetic neuropathy. However, the optimum stimulus-response parameters that identify patients with spinal
Externí odkaz:
https://doaj.org/article/b9484533c7384c32a5976567f7629a19
Publikováno v:
Diagnostics, Vol 11, Iss 2, p 283 (2021)
Impaired rate-dependent depression (RDD) of the spinal H-reflex occurs in diabetic rodents and a sub-set of patients with painful diabetic neuropathy. RDD is unaffected in animal models of painful neuropathy associated with peripheral pain mechanisms
Externí odkaz:
https://doaj.org/article/7f623f77f95e4d829fdce86e2893b517
Publikováno v:
Frontiers in Neuroscience, Vol 12 (2018)
The muscarinic acetylcholine type 1 receptor (M1R) is a metabotropic G protein-coupled receptor. Knockout of M1R or exposure to selective or specific receptor antagonists elevates neurite outgrowth in adult sensory neurons and is therapeutic in diver
Externí odkaz:
https://doaj.org/article/a3c4050c9a9a48f3a33e67a89cf9cd9c
Publikováno v:
Journal of Diabetes Research, Vol 2018 (2018)
Externí odkaz:
https://doaj.org/article/659eb9bcdc7f40e098beeafc1b12f76d
Autor:
Michal K. Handzlik, Jivani M. Gengatharan, Katie E. Frizzi, Grace H. McGregor, Cameron Martino, Gibraan Rahman, Antonio Gonzalez, Ana M. Moreno, Courtney R. Green, Lucie S. Guernsey, Terry Lin, Patrick Tseng, Yoichiro Ideguchi, Regis J. Fallon, Amandine Chaix, Satchidananda Panda, Prashant Mali, Martina Wallace, Rob Knight, Marin L. Gantner, Nigel A. Calcutt, Christian M. Metallo
Publikováno v:
Nature, vol 614, iss 7946
Diabetes represents a spectrum of disease in which metabolic dysfunction damages multiple organ systems including liver, kidneys and peripheral nerves1,2. Although the onset and progression of these co-morbidities are linked with insulin resistance,