Výsledky vyhledávání - "Nigel R. Parry"

Chimeric GB virus B genomes containing hepatitis C virus p7 are infectious in vivo

Autor: Mark Harris, Nigel R. Parry, Rachel Trowbridge, Pia Thommes, Stephen Griffin, David J. Rowlands, Helen Bright

Publikováno v: Journal of Hepatology

Background/Aims The development of new therapies for hepatitis C virus (HCV) infection has been hampered by the lack of a small animal model. GB virus B (GBV-B), which infects new world monkeys, has been proposed as a surrogate system for HCV replica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a31414a76cc2fa532bc357ec9d3fa681
https://doi.org/10.1016/j.jhep.2008.07.020

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Studies on acyl pyrrolidine inhibitors of HCV RNA-dependent RNA polymerase to identify a molecule with replicon antiviral activity

Autor: Thomas J. Carr, Dashyant Dhanak, David Haigh, George Burton, Victor K. Johnson, Pia Thommes, Glenn A. Hofmann, Robert T. Sarisky, Martin John Slater, Juili Lin-Goerke, Thomas W. Ku, Nigel R. Parry, Terry Kiesow

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 17:1930-1933

The SAR development is described for a series of N -acyl pyrrolidine inhibitors of the Hepatitis C virus RNA-dependent RNA polymerase, NS5B, from tractable Δ21 enzyme inhibitors to an example with antiviral activity in a cellular assay (HCV replicon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0b6af3e4c306b015a4448930334369f
https://doi.org/10.1016/j.bmcl.2007.01.034

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Pyrrolidine-5,5-trans-lactams. 4. Incorporation of a P3/P4 Urea Leads to Potent Intracellular Inhibitors of Hepatitis C Virus NS3/4A Protease

Autor: Elizabeth M. Amphlett, Martin R. Johnson, Gail Mills, Martin John Slater, Nigel R. Parry, Seb J. Carey, Donald O. Somers, Tadeusz Skarzynski, Alan J. W. Stewart, Paul Bamborough, David M. Andrews, Paul Spencer Jones

Publikováno v: Organic Letters. 5:4627-4630

[reaction: see text] In this, the first of two Letters, we describe how a P3/P4 urea linking unit was used to greatly enhance the biochemical and replicon potency of inhibitors based upon the pyrrolidine-5,5-trans-lactam template. Compound 7b demonst

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09854488289a3d17fc7674c0650f85ac
https://doi.org/10.1021/ol035826v

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Design and Synthesis of Pyrrolidine-5,5‘-trans-Lactams (5-Oxo-hexahydropyrrolo[3,2-b]pyrroles) as Novel Mechanism-Based Inhibitors of Human Cytomegalovirus Protease. 4. Antiviral Activity and Plasma Stability

Autor: Deborah L. Jackson, Graham J Hart, Angela Patikis, Gordon G. Weingarten, Nigel R. Parry, Alan D. Borthwick, James Michael Woolven, Terry M. Haley, Dave E. Davies, Anne M. Exall, Peter Franz Ertl, Naimisha Trivedi

Publikováno v: Journal of Medicinal Chemistry. 46:4428-4449

A series of chiral, (S)-proline-alpha-methylpyrrolidine-5,5-trans-lactam serine protease inhibitors has been developed as antivirals of human cytomegalovirus (HCMV). The SAR of the functionality on the proline nitrogen has shown that derivatives of p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c2b6a73dae4a667f9c1ac9169b95e88
https://doi.org/10.1021/jm030810w

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Rapid in vitro selection of human immunodeficiency virus type 1 resistant to 3'-thiacytidine inhibitors due to a mutation in the YMDD region of reverse transcriptase

Autor: Brendan Larder, Nigel R. Parry, Margaret Tisdale, S. D. Kemp

Publikováno v: Proceedings of the National Academy of Sciences. 90:5653-5656

Resistant variants of human immunodeficiency virus type 1 (HIV-1) have been selected by limited passage in MT4 cells of both wild-type and 3'-azido-3'-deoxythymidine (AZT, zidovudine)-resistant strains with the nucleoside analogues (-)-2'-deoxy-3'-th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b1453d002730b459ef7cdf831895f63
https://doi.org/10.1073/pnas.90.12.5653

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Synthesis of N-Alkyl Substituted Indolocarbazoles as Potent Inhibitors of Human Cytomegalovirus Replication

Autor: Adeline Walters, Roger W. Randall, Stuart G. Cockerill, Kam Gohil, Clive Yeates, Nigel R. Parry, R.W. Bonser, Ed Robinson, Robert Baxter, Martin John Slater, Wendy Snowden

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 11:1993-1995

The synthesis and antiviral evaluation of unsymmetrical indolocarbazole derivatives of Arcyriaflavin A, substituted with a range of alkyl groups at the indole nitrogen, is described. Structure–activity relationships in this series against human cyt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f70489376f45fb8f68bd5da9cdaf6f98
https://doi.org/10.1016/s0960-894x(01)00352-3

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Synthesis and antiviral activity of acyclovir-5′-(phenyl methoxy alaninyl) phosphate as a possible membrane-soluble nucleotide prodrug

Autor: Alex Perry, Martin John Slater, Sarah Harris, Nigel R. Parry, Christopher McGuigan

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 10:645-647

We describe a synthesis of acyclovir-5'-(phenyl methoxy alaninyl) phosphate (2) from acyclovir (1). This compound was designed to act as a lipophilic, membrane-soluble prodrug of the free nucleotide. However, the biological activities of this derivat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0057fc4ab3127b3027abe3ad1b2a03c4
https://doi.org/10.1016/s0960-894x(00)00061-5

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