Zobrazeno 1 - 10
of 113
pro vyhledávání: '"Nigel, Temperton"'
Autor:
Sneha Vishwanath, George William Carnell, Martina Billmeier, Luis Ohlendorf, Patrick Neckermann, Benedikt Asbach, Charlotte George, Maria Suau Sans, Andrew Chan, Joey Olivier, Angalee Nadesalingam, Sebastian Einhauser, Nigel Temperton, Diego Cantoni, Joe Grove, Ingo Jordan, Volker Sandig, Paul Tonks, Johannes Geiger, Christian Dohmen, Verena Mummert, Anne Rosalind Samuel, Christian Plank, Rebecca Kinsley, Ralf Wagner, Jonathan Luke Heeney
Publikováno v:
npj Vaccines, Vol 9, Iss 1, Pp 1-9 (2024)
Abstract Updates of SARS-CoV-2 vaccines are required to generate immunity in the population against constantly evolving SARS-CoV-2 variants of concerns (VOCs). Here we describe three novel in-silico designed spike-based antigens capable of inducing n
Externí odkaz:
https://doaj.org/article/82ef274560d34dc98c35687c198efcf5
Autor:
Claudia Maria Trombetta, Giulia Accardi, Anna Aiello, Anna Calabrò, Calogero Caruso, Mattia Emanuela Ligotti, Serena Marchi, Emanuele Montomoli, Martin Mayora Neto, Nigel Temperton, Giuseppina Candore
Publikováno v:
Immunity & Ageing, Vol 21, Iss 1, Pp 1-10 (2024)
Abstract Background Although it is well known that the older people have been the most susceptible to COVID-19, there are conflicting data on the susceptibility of centenarians. Two epidemiological study have shown that older centenarians (> 101 year
Externí odkaz:
https://doaj.org/article/449bf73678ce427e8fd5e4d94e7258eb
Autor:
Alessandro Manenti, Emanuele Montomoli, Francesca Dapporto, Maria Altamura, Nigel Temperton, Pietro Piu, Claudia Semplici, Eleonora Molesti, Vittoria Forconi, Roberta Antonelli
Publikováno v:
F1000Research, Vol 13 (2024)
Background Over the past few decades, World Health Organization (WHO) has made massive efforts to promote the development of a vaccine against Lassa virus (LASV), one of the top ten priority pathogens for research and development under the WHO R&D Bl
Externí odkaz:
https://doaj.org/article/b121c6ddc3e545eeba3dd457cb08a97c
Emerging variants develop total escape from potent monoclonal antibodies induced by BA.4/5 infection
Autor:
Chang Liu, Raksha Das, Aiste Dijokaite-Guraliuc, Daming Zhou, Alexander J. Mentzer, Piyada Supasa, Muneeswaran Selvaraj, Helen M. E. Duyvesteyn, Thomas G. Ritter, Nigel Temperton, Paul Klenerman, Susanna J. Dunachie, Neil G. Paterson, Mark A. Williams, David R. Hall, Elizabeth E. Fry, Juthathip Mongkolsapaya, Jingshan Ren, David I. Stuart, Gavin R. Screaton
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract The rapid evolution of SARS-CoV-2 is driven in part by a need to evade the antibody response in the face of high levels of immunity. Here, we isolate spike (S) binding monoclonal antibodies (mAbs) from vaccinees who suffered vaccine break-th
Externí odkaz:
https://doaj.org/article/cc28ab08066f4f34ade2b16555c78a91
Autor:
Daming Zhou, Piyada Supasa, Chang Liu, Aiste Dijokaite-Guraliuc, Helen M. E. Duyvesteyn, Muneeswaran Selvaraj, Alexander J. Mentzer, Raksha Das, Wanwisa Dejnirattisai, Nigel Temperton, Paul Klenerman, Susanna J. Dunachie, Elizabeth E. Fry, Juthathip Mongkolsapaya, Jingshan Ren, David I. Stuart, Gavin R. Screaton
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Under pressure from neutralising antibodies induced by vaccination or infection the SARS-CoV-2 spike gene has become a hotspot for evolutionary change, leading to the failure of all mAbs developed for clinical use. Most potent antibodies bin
Externí odkaz:
https://doaj.org/article/40347f991a6543e8a3b3edb8d9a26a4b
Autor:
Anna L. Beukenhorst, Jacopo Frallicciardi, Keira L. Rice, Martin H. Koldijk, Joana C. Moreira de Mello, Jaco M. Klap, Christoforos Hadjichrysanthou, Clarissa M. Koch, Kelly A. S. da Costa, Nigel Temperton, Babette A. de Jong, Helene Vietsch, Bertjan Ziere, Boris Julg, Wouter Koudstaal, Jaap Goudsmit
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-8 (2024)
Abstract Avian A(H5N1) influenza virus poses an elevated zoonotic threat to humans, and no pharmacological products are currently registered for fast-acting pre-exposure protection in case of spillover leading to a pandemic. Here, we show that an epi
Externí odkaz:
https://doaj.org/article/b85d0a98851e4b6a93bc94df6dc119e5
Autor:
Chinedu A. Ugwu, Oluwasina Alao, Oluwagboadurami G. John, Blossom Akinnawo, Israel Ajayi, Ooreofe Odebode, Ifeoluwa Bejide, Allan Campbell, Julian Campbell, Jolly A. Adole, Idowu B. Olawoye, Kazeem Akano, Johnson Okolie, Philomena Eromon, Peter Olaitan, Ajibola Olagunoye, Ibukun Adebayo, Victor Adebayo, Elizabeth Babalola, Omowumi Abioye, Nnennaya Ajayi, Emeka Ogah, Kingsley Ukwaja, Sylvanus Okoro, Ogbonnaya Oje, Ojide Chiedozie Kingsley, Matthew Eke, Venatius Onyia, Olivia Achonduh-Atijegbe, Friday Elechi Ewah, Mary Obasi, Violet Igwe, Olufemi Ayodeji, Abejegah Chukwuyem, Sampson Owhin, Nicholas Oyejide, Sylvester Abah, Winifred Ingbian, Moyosoore Osoba, Ahmed Alebiosu, Angalee Nadesalingam, Ernest T. Aguinam, George Carnell, Nina Krause, Andrew Chan, Charlotte George, Rebecca Kinsley, Paul Tonks, Nigel Temperton, Jonathan Heeney, Christian Happi
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionOne of the unexpected outcomes of the COVID-19 pandemic was the relatively low levels of morbidity and mortality in Africa compared to the rest of the world. Nigeria, Africa's most populous nation, accounted for less than 0.01% of the glo
Externí odkaz:
https://doaj.org/article/5d7d72dbff944ae9b6192989b0ff04ec
Autor:
Cecilia Di Genova, Gabrielle Sutton, Romain Paillot, Nigel Temperton, Stéphane Pronost, Simon D. Scott
Publikováno v:
Virus Research, Vol 339, Iss , Pp 199262- (2024)
Infection with equid herpesvirus 1 (EHV-1), a DNA virus of the Herpesviridae family represents a significant welfare issue in horses and a great impact on the equine industry. During EHV-1 infection, entry of the virus into different cell types is co
Externí odkaz:
https://doaj.org/article/7f303ac92f9146d3a5c4e5c216d23865
Autor:
Dennis Horvath, Nigel Temperton, Martin Mayora-Neto, Kelly Da Costa, Diego Cantoni, Reinhold Horlacher, Armin Günther, Alexander Brosig, Jenny Morath, Barbara Jakobs, Marcus Groettrup, Heinz Hoschuetzky, Jacques Rohayem, Jan ter Meulen
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract SARS-CoV-2 continues to circulate in the human population necessitating regular booster immunization for its long-term control. Ideally, vaccines should ideally not only protect against symptomatic disease, but also prevent transmission via
Externí odkaz:
https://doaj.org/article/4520b07600b543c4bea38899ef4dcba3
Autor:
Diego Cantoni, Martin Mayora-Neto, Mariliza Derveni, Kelly da Costa, Joanne Del Rosario, Veronica O. Ameh, Claude T. Sabeta, Bethany Auld, Arran Hamlet, Ian M. Jones, Edward Wright, Simon D. Scott, Efstathios S. Giotis, Ashley C. Banyard, Nigel Temperton
Publikováno v:
Frontiers in Public Health, Vol 11 (2023)
IntroductionThe Eidolon helvum fruit bat is one of the most widely distributed fruit bats in Africa and known to be a reservoir for several pathogenic viruses that can cause disease in animals and humans. To assess the risk of zoonotic spillover, we
Externí odkaz:
https://doaj.org/article/d42ed96d25294ba98627ea837d855a37