Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Nigam M. Mishra"'
Autor:
Nigam M. Mishra, Izabela Stolarzewicz, David Cannaerts, Joris Schuermans, Rob Lavigne, Yannick Looz, Bart Landuyt, Liliane Schoofs, Dominique Schols, Jan Paeshuyse, Peter Hickenbotham, Martha Clokie, Walter Luyten, Erik V. Van der Eycken, Yves Briers
Publikováno v:
Frontiers in Microbiology, Vol 9 (2018)
Vancomycin is a glycopeptide antibiotic that inhibits transpeptidation during cell wall synthesis by binding to the D-Ala-D-Ala termini of lipid II. For long, it has been used as a last resort antibiotic. However, since the emergence of the first van
Externí odkaz:
https://doaj.org/article/0b2f49f11e0a456f9270736b181fd597
Autor:
Alshaima'a M. Qunies, Nigam M. Mishra, Brittany D. Spitznagel, Yu Du, Valerie S. Acuña, C. David Weaver, Kyle A. Emmitte
Publikováno v:
Bioorganicmedicinal chemistry letters. 76
In this Letter we describe structure-activity relationship (SAR) studies conducted in five distinct regions of a new 2-amino-N-phenylacetamides series of Slack potassium channel inhibitors exemplified by recently disclosed high-throughput screening (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf246d3f681274747c32621e15715f87
https://pubmed.ncbi.nlm.nih.gov/36184030
https://pubmed.ncbi.nlm.nih.gov/36184030
Autor:
Corinna Schüß, Kyle A. Emmitte, Jan Stichel, Oanh Vu, Jens Meiler, C. David Weaver, Helen M. Cox, Nigam M. Mishra, Iain R. Tough, Annette G. Beck-Sickinger, Mario Schubert, Yu Du
Publikováno v:
Journal of Medicinal Chemistry. 64:2801-2814
Human neuropeptide Y receptors (Y1R, Y2R, Y4R, and Y5R) belong to the superfamily of G protein-coupled receptors and play an important role in the regulation of food intake and energy metabolism. We identified and characterized the first selective Y4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::83326529104d38a3671fa39f6bfc0219
https://doi.org/10.1021/acs.jmedchem.0c02000
https://doi.org/10.1021/acs.jmedchem.0c02000
Autor:
Yu Du, Francis J. Prael, Nigam M. Mishra, Kyle A. Emmitte, Alshaima’a M. Qunies, Jerod S. Denton, Brittany D. Spitznagel, C. David Weaver, Roman M. Lazarenko, Krystian A. Kozek
Publikováno v:
ACS Chemical Neuroscience. 11:3658-3671
Malignant migrating partial seizures of infancy is a rare, devastating form of epilepsy most commonly associated with gain-of-function mutations in the potassium channel, Slack. Not only is this condition almost completely pharmacoresistant, there ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b9ce358836bc0c2bc3417b4fa54a60a
https://doi.org/10.1021/acschemneuro.0c00583
https://doi.org/10.1021/acschemneuro.0c00583
Autor:
Corinna, Schüß, Oanh, Vu, Mario, Schubert, Yu, Du, Nigam M, Mishra, Iain R, Tough, Jan, Stichel, C David, Weaver, Kyle A, Emmitte, Helen M, Cox, Jens, Meiler, Annette G, Beck-Sickinger
Publikováno v:
Journal of medicinal chemistry. 64(5)
Human neuropeptide Y receptors (Y
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0d2802dd65cb57d60b07511534523589
https://pubmed.ncbi.nlm.nih.gov/33595306
https://pubmed.ncbi.nlm.nih.gov/33595306
Autor:
Rohit Sampat, Jin Liu, Kyle A. Emmitte, Nigam M. Mishra, Yu-Chieh Wang, Hamed S. Hayatshahi, Abhishek Parab, Ashwini Zolekar, Xiaoyan Liao, Yin Ying Ho, Victor Lin, Peter Hoffmann
Publikováno v:
British Journal of Cancer
Background Although NGLY1 is known as a pivotal enzyme that catalyses the deglycosylation of denatured glycoproteins, information regarding the responses of human cancer and normal cells to NGLY1 suppression is limited. Methods We examined how NGLY1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb27c1928570ad995c1020fcb2dce854
http://europepmc.org/articles/PMC6288164
http://europepmc.org/articles/PMC6288164
Autor:
Matteo Pagliari, Marina de Bernard, Francesca Vallese, Paola Berto, Nigam M. Mishra, Gaia Codolo, Giuseppe Zanotti
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1861:3263-3271
Background Helicobacter pylori is a bacterium that affects about 50% of the world population and, despite being often asymptomatic, it is responsible of several gastric diseases, from gastritis to gastric cancer. The protein Lpp20 (HP1456) plays an i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f4a62ea89656e0b24923f3a64c03454
https://doi.org/10.1016/j.bbagen.2017.09.017
https://doi.org/10.1016/j.bbagen.2017.09.017
Autor:
Jin Liu, Ashwini Zolekar, Yin Ying Ho, Kyle A. Emmitte, Abhishek Parab, Nigam M. Mishra, Peter Hoffmann, Rohit Sampat, Hamed S. Hayatshahi, Yu-Chieh Wang, Victor Lin, Xiaoyan Liao
Publikováno v:
Cancer Research. 80:A28-A28
Although NGLY1 is known as a pivotal enzyme that catalyzes the deglycosylation of denatured glycoproteins, information regarding the responses of human cancer and normal cells to NGLY1 suppression is limited. While studying the NGLY1 deficiency-cause
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e330808d196a438e64728eda9772b994
https://doi.org/10.1158/1538-7445.mel2019-a28
https://doi.org/10.1158/1538-7445.mel2019-a28
Publikováno v:
Advanced Synthesis & Catalysis. 356:1029-1037
A simple protocol for the synthesis of mono-propargylic amines (IV), (VI), (VIII), (XI), and (XIV) as well as symmetrical dipropargylic amines (XV) from α-amino esters, aldehydes or ketones, and alkynes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d786ed3f6ab5b64c0b5dda4e1d4ae8e1
https://doi.org/10.1002/adsc.201300888
https://doi.org/10.1002/adsc.201300888
Autor:
Victor J.T. Lin, Ashwini Zolekar, Nigam M. Mishra, Yin Ying Ho, Hamed S. Hayatshahi, Abhishek Parab, Rohit Sampat, Xiaoyan Liao, Peter Hoffmann, Jin Liu, Kyle A. Emmitte, Yu-Chieh Wang
Publikováno v:
Cancer Research. 79:3048-3048
As an enzyme that removes N-glycans from glycopeptides, N-glycanase 1 (NGLY1) deglycosylates denatured glycoproteins and allows proteasome-mediated protein degradation to efficiently occur. Although NGLY1 is known for this pivotal function, informati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe1c7c36afa8f64af229a0597d31e19c
https://doi.org/10.1158/1538-7445.am2019-3048
https://doi.org/10.1158/1538-7445.am2019-3048