Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Nieves Gomez-Hurtado"'
Autor:
Daniel J. Blackwell, Michela Faggioni, Matthew J. Wleklinski, Nieves Gomez-Hurtado, Raghav Venkataraman, Chelsea E. Gibbs, Franz J. Baudenbacher, Shiaoching Gong, Glenn I. Fishman, Patrick M. Boyle, Karl Pfeifer, Bjorn C. Knollmann
Publikováno v:
JCI Insight, Vol 7, Iss 3 (2022)
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an arrhythmia syndrome caused by gene mutations that render RYR2 Ca release channels hyperactive, provoking spontaneous Ca release and delayed afterdepolarizations (DADs). What remains u
Externí odkaz:
https://doaj.org/article/2aa7c799ff5c4e1e88cbf5f6f46506a5
Autor:
Daniel Blackwell, Michela Faggioni, Wleklinski Matthew, Nieves Gomez-Hurtado, Raghav Venkataraman, Franz J Baudenbacher, Shiaoching Gong, Glenn I Fishman, Karl Pfeifer, Bjorn C Knollmann
Publikováno v:
Circulation. 144
Introduction: Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a genetic arrhythmia syndrome caused by mutations that render intracellular calcium release channels hyperactive during adrenergic stress. Hyperactive calcium release has a
Autor:
Daniel J. Blackwell, Michela Faggioni, Matthew J. Wleklinski, Nieves Gomez-Hurtado, Raghav Venkataraman, Chelsea E. Gibbs, Franz J. Baudenbacher, Shiaoching Gong, Glenn I. Fishman, Patrick M. Boyle, Karl Pfeifer, Bjorn C. Knollmann
Publikováno v:
JCI insight. 7(3)
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an arrhythmia syndrome caused by gene mutations that render RYR2 Ca release channels hyperactive, provoking spontaneous Ca release and delayed afterdepolarizations (DADs). What remains u
Autor:
Cris dos Remedios, Bjorn C. Knollmann, Nicole A. Beard, Ye Wint Oo, Nieves Gomez-Hurtado, Peter C. M. Molenaar, Robyn T. Rebbeck, Derek R. Laver, Razvan L. Cornea, Kafa Walweel, Dirk F. van Helden
Publikováno v:
Journal of Molecular and Cellular Cardiology. 130:96-106
Calmodulin (CaM) is a Ca-binding protein that binds to, and can directly inhibit cardiac ryanodine receptor calcium release channels (RyR2). Animal studies have shown that RyR2 hyperphosphorylation reduces CaM binding to RyR2 in failing hearts, but d
Autor:
Daniel J. Blackwell, Nieves Gomez-Hurtado, Michael Frisk, Arnt E. Fiane, William E. Louch, Shan Parikh, Christen P. Dahl, Dmytro O. Kryshtal, Lili Wang, Kyungsoo Kim, Theis Tønnessen, Bjorn C. Knollmann
Publikováno v:
Circulation Research. 121:1323-1330
Rationale: Human-induced pluripotent stem cell–derived cardiomyocytes (hiPSC-CM) are increasingly being used for modeling heart disease and are under development for regeneration of the injured heart. However, incomplete structural and functional m
Autor:
María Fernández-Velasco, Nieves Gomez-Hurtado, Carmen Delgado, Rafael Aizpún, Philippe Mateo, Ana Maria Gomez, Almudena Val-Blasco, Jessica Sabourin, Alejandro Domínguez-Rodríguez, Jean-Pierre Benitah
Publikováno v:
The Journal of Physiology. 595:4227-4243
Key points Leptin, is a 16 kDa pleiotropic peptide not only primarily secreted by adipocytes, but also produced by other tissues, including the heart. Controversy exists regarding the adverse and beneficial effects of leptin on the heart We analysed
Autor:
Bjorn C. Knollmann, Kyungsoo Kim, Robyn T. Rebbeck, Jeffrey N. Johnston, Razvan L. Cornea, Dmytro O. Kryshtal, Nieves Gomez-Hurtado, Suzanne M. Batiste, Daniel J. Blackwell
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 116(11)
Ca(2+) leak via ryanodine receptor type 2 (RyR2) can cause potentially fatal arrhythmias in a variety of heart diseases and has also been implicated in neurodegenerative and seizure disorders, making RyR2 an attractive therapeutic target for drug dev
Autor:
Fernando Arribas, Evangelina Mérida-Herrero, Luis M. Ruilope, Eduardo Hernández, Carmen Delgado, Nieves Gomez-Hurtado, Rafael Salguero, Juan F. Delgado, Héctor Bueno, Gema Ruiz-Hurtado, Jorge Solis, José Alberto Navarro-García, Manuel Praga, Teresa Bada-Bosch, Almudena Val-Blasco, Elena Rodríguez-Sánchez, Jennifer Aceves-Ripoll, María Fernández-Velasco, Makoto Kuro-o
[Background]: Cardiac dysfunction and arrhythmia are common and onerous cardiovascular events in end-stage renal disease (ESRD) patients, especially those on dialysis. Fibroblast growth factor (FGF)-23 is a phosphate-regulating hormone whose levels d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::113ecd3b6ee2c78f4fe005650725486b
https://hdl.handle.net/11268/7856
https://hdl.handle.net/11268/7856
Autor:
Andrew L. Papez, Hyun Seok Hwang, Dan Ye, Christina G. Loporcaro, Yung R. Lau, Maully J. Shah, Bjorn C. Knollmann, Melissa L. Calvert, Nicole J. Boczek, Walter J. Chazin, Ronald J. Kanter, Michael J. Ackerman, David J. Tester, Dmytro O. Kryshtal, Nieves Gomez-Hurtado, Christopher N. Johnson
Publikováno v:
Circulation: Cardiovascular Genetics. 9:136-146
Background— Calmodulin (CaM) is encoded by 3 genes, CALM1 , CALM2 , and CALM3 , all of which harbor pathogenic variants linked to long QT syndrome (LQTS) with early and severe expressivity. These LQTS-causative variants reduce CaM affinity to Ca 2+
Autor:
Walter J. Chazin, Kafa Walweel, Derek R. Laver, Dirk F. van Helden, Ye Wint Oo, Christopher N. Johnson, Cris dos Remedios, Nieves Gomez-Hurtado, Nicole A. Beard, Bjorn C. Knollmann
Publikováno v:
Journal of the American College of Cardiology. 70:115-117
Calmodulin (CaM) is a calcium-binding protein that can directly inhibit cardiac ryanodine receptor calcium release channels (ryanodine receptor 2 [RyR2]) [(1)][1]. CaM mutations can cause an autosomal-dominant form of catecholaminergic polymorphic ve