Development of a scintillation proximity assay for [ ³ H]epibatidine binding sites of Tetronarce californica muscle-type nicotinic acetylcholine receptor.

Autor: Springer F; Bundeswehr Institute for Pharmacology and Toxicology, Neuherbergstraße 11, Munich 80937, Germany; Chair for Drug Formulation and Delivery, Julius-Maximilians University Wuerzburg, Am Hubland, Wuerzburg 97074, Germany., Freisleben M; Bundeswehr Institute for Pharmacology and Toxicology, Neuherbergstraße 11, Munich 80937, Germany; Institute of Precision Medicine, Furtwangen University, Jakob-Kienzle-Straße 17, Villingen-Schwenningen 78054, Germany., Muschik S; Bundeswehr Institute for Pharmacology and Toxicology, Neuherbergstraße 11, Munich 80937, Germany., Kohl M; Institute of Precision Medicine, Furtwangen University, Jakob-Kienzle-Straße 17, Villingen-Schwenningen 78054, Germany., Worek F; Bundeswehr Institute for Pharmacology and Toxicology, Neuherbergstraße 11, Munich 80937, Germany., Meinel L; Chair for Drug Formulation and Delivery, Julius-Maximilians University Wuerzburg, Am Hubland, Wuerzburg 97074, Germany., Seeger T; Bundeswehr Institute for Pharmacology and Toxicology, Neuherbergstraße 11, Munich 80937, Germany., Niessen KV; Bundeswehr Institute for Pharmacology and Toxicology, Neuherbergstraße 11, Munich 80937, Germany. Electronic address: KarinNiessen@bundeswehr.org.

Publikováno v: Toxicology letters [Toxicol Lett] 2024 Nov; Vol. 401, pp. 108-115. Date of Electronic Publication: 2024 Sep 12.

Synthesis and biological evaluation of novel MB327 analogs as resensitizers for desensitized nicotinic acetylcholine receptors after intoxication with nerve agents.

Autor: Bernauer T; Department of Pharmacy - Center for Drug Research, Ludwig-Maximilians-Universität München, Munich, Germany., Nitsche V; Department of Pharmacy - Center for Drug Research, Ludwig-Maximilians-Universität München, Munich, Germany., Kaiser J; Institute for Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Düsseldorf, Germany., Gertzen CGW; Institute for Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Düsseldorf, Germany., Höfner G; Department of Pharmacy - Center for Drug Research, Ludwig-Maximilians-Universität München, Munich, Germany., Niessen KV; Bundeswehr Institute of Pharmacology and Toxicology, Munich, Germany., Seeger T; Bundeswehr Institute of Pharmacology and Toxicology, Munich, Germany., Steinritz D; Bundeswehr Institute of Pharmacology and Toxicology, Munich, Germany., Worek F; Bundeswehr Institute of Pharmacology and Toxicology, Munich, Germany., Gohlke H; Institute for Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Düsseldorf, Germany; John von Neumann Institute for Computing (NIC), Jülich Supercomputing Centre (JSC), Institute of Biological Information Processing (IBI-7: Structural Biochemistry) & Institute of Bio- and Geosciences (IBG-4: Bioinformatics), Forschungszentrum Jülich, Jülich, Germany., Wanner KT; Department of Pharmacy - Center for Drug Research, Ludwig-Maximilians-Universität München, Munich, Germany., Paintner FF; Department of Pharmacy - Center for Drug Research, Ludwig-Maximilians-Universität München, Munich, Germany. Electronic address: Franz.Paintner@cup.uni-muenchen.de.

Publikováno v: Toxicology letters [Toxicol Lett] 2024 Jun; Vol. 397, pp. 151-162. Date of Electronic Publication: 2024 May 15.

MS Binding Assays with UNC0642 as reporter ligand for the MB327 binding site of the nicotinic acetylcholine receptor.

Autor: Nitsche V; Department of Pharmacy - Center for Drug Research, Ludwig-Maximilians-Universität München, Munich, Germany., Höfner G; Department of Pharmacy - Center for Drug Research, Ludwig-Maximilians-Universität München, Munich, Germany., Kaiser J; Institute for Pharmaceutical and Medicinal Chemistry, Heinrich Heine Universität Düsseldorf, Düsseldorf, Germany., Gertzen CGW; Institute for Pharmaceutical and Medicinal Chemistry, Heinrich Heine Universität Düsseldorf, Düsseldorf, Germany., Seeger T; Bundeswehr Institute of Pharmacology and Toxicology, Munich, Germany., Niessen KV; Bundeswehr Institute of Pharmacology and Toxicology, Munich, Germany., Steinritz D; Bundeswehr Institute of Pharmacology and Toxicology, Munich, Germany., Worek F; Bundeswehr Institute of Pharmacology and Toxicology, Munich, Germany., Gohlke H; Institute for Pharmaceutical and Medicinal Chemistry, Heinrich Heine Universität Düsseldorf, Düsseldorf, Germany; Institute of Bio, and Geosciences (IBG-4: Bioinformatics), Forschungszentrum Jülich, Jülich, Germany., Paintner FF; Department of Pharmacy - Center for Drug Research, Ludwig-Maximilians-Universität München, Munich, Germany., Wanner KT; Department of Pharmacy - Center for Drug Research, Ludwig-Maximilians-Universität München, Munich, Germany. Electronic address: klaus.wanner@cup.uni-muenchen.de.

Publikováno v: Toxicology letters [Toxicol Lett] 2024 Feb; Vol. 392, pp. 94-106. Date of Electronic Publication: 2024 Jan 10.

Diagnostics and treatment of nerve agent poisoning-current status and future developments.

Autor: Amend N; Bundeswehr Institute of Pharmacology and Toxicology, Munich, Germany., Niessen KV; Bundeswehr Institute of Pharmacology and Toxicology, Munich, Germany., Seeger T; Bundeswehr Institute of Pharmacology and Toxicology, Munich, Germany., Wille T; Bundeswehr Institute of Pharmacology and Toxicology, Munich, Germany., Worek F; Bundeswehr Institute of Pharmacology and Toxicology, Munich, Germany., Thiermann H; Bundeswehr Institute of Pharmacology and Toxicology, Munich, Germany.

Publikováno v: Annals of the New York Academy of Sciences [Ann N Y Acad Sci] 2020 Nov; Vol. 1479 (1), pp. 13-28. Date of Electronic Publication: 2020 Mar 21.

Synthesis of a Series of Non-Symmetric Bispyridinium and Related Compounds and Their Affinity Characterization at the Nicotinic Acetylcholine Receptor.

Autor: Rappenglück S; Department of Pharmacy, Center for Drug Research, Ludwig-Maximilians-Universität München, Butenandtstrasse 5-13, 81377, Munich, Germany., Sichler S; Department of Pharmacy, Center for Drug Research, Ludwig-Maximilians-Universität München, Butenandtstrasse 5-13, 81377, Munich, Germany., Höfner G; Department of Pharmacy, Center for Drug Research, Ludwig-Maximilians-Universität München, Butenandtstrasse 5-13, 81377, Munich, Germany., Wein T; Department of Pharmacy, Center for Drug Research, Ludwig-Maximilians-Universität München, Butenandtstrasse 5-13, 81377, Munich, Germany., Niessen KV; Bundeswehr Institute of Pharmacology and Toxicology, Neuherbergstrasse 11, 80937, Munich, Germany., Seeger T; Bundeswehr Institute of Pharmacology and Toxicology, Neuherbergstrasse 11, 80937, Munich, Germany., Paintner FF; Department of Pharmacy, Center for Drug Research, Ludwig-Maximilians-Universität München, Butenandtstrasse 5-13, 81377, Munich, Germany., Worek F; Bundeswehr Institute of Pharmacology and Toxicology, Neuherbergstrasse 11, 80937, Munich, Germany., Thiermann H; Bundeswehr Institute of Pharmacology and Toxicology, Neuherbergstrasse 11, 80937, Munich, Germany., Wanner KT; Department of Pharmacy, Center for Drug Research, Ludwig-Maximilians-Universität München, Butenandtstrasse 5-13, 81377, Munich, Germany.

Publikováno v: ChemMedChem [ChemMedChem] 2018 Dec 20; Vol. 13 (24), pp. 2653-2663. Date of Electronic Publication: 2018 Nov 27.