Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Nieske Brouwer"'
Autor:
Daniëlle C. Voshart, Takuya Oshima, Yuting Jiang, Gideon P. van der Linden, Anna P. Ainslie, Luiza Reali Nazario, Fleur van Buuren-Broek, Ayla C. Scholma, Hilmar R.J. van Weering, Nieske Brouwer, Jeffrey Sewdihal, Uilke Brouwer, Rob P. Coppes, Inge R. Holtman, Bart J.L. Eggen, Susanne M. Kooistra, Lara Barazzuol
Publikováno v:
Cell Reports, Vol 43, Iss 2, Pp 113764- (2024)
Summary: Over half of patients with brain tumors experience debilitating and often progressive cognitive decline after radiotherapy treatment. Microglia, the resident macrophages in the brain, have been implicated in this decline. In response to vari
Externí odkaz:
https://doaj.org/article/bae07cfdb73044fea7306f15d1eb7d28
Autor:
Kitty Reemst, Laura Kracht, Janssen M. Kotah, Reza Rahimian, Astrid A. S. van Irsen, Gonzalo Congrains Sotomayor, Laura N. Verboon, Nieske Brouwer, Sophie Simard, Gustavo Turecki, Naguib Mechawar, Susanne M. Kooistra, Bart J. L. Eggen, Aniko Korosi
Publikováno v:
Translational Psychiatry, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Early-life stress (ELS) leads to increased vulnerability to psychiatric disorders including depression later in life. Neuroinflammatory processes have been implicated in ELS-induced negative health outcomes, but how ELS impacts microglia, th
Externí odkaz:
https://doaj.org/article/db2a1285bcce4eab802b36ede32826ef
Autor:
Xiaoming Zhang, Laura Kracht, Antonio M. Lerario, Marissa L. Dubbelaar, Nieske Brouwer, Evelyn M. Wesseling, Erik W. G. M. Boddeke, Bart J. L. Eggen, Susanne M. Kooistra
Publikováno v:
Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-19 (2022)
Abstract Background Microglia are the tissue-resident macrophages of the CNS. They originate in the yolk sac, colonize the CNS during embryonic development and form a self-sustaining population with limited turnover. A consequence of their relative s
Externí odkaz:
https://doaj.org/article/3973528986d64d68a5883cd398983c49
Autor:
Anneke Miedema, Emma Gerrits, Nieske Brouwer, Qiong Jiang, Laura Kracht, Michel Meijer, Erik Nutma, Regina Peferoen-Baert, Anna T. E. Pijnacker, Evelyn M. Wesseling, Marion H. C. Wijering, Hans-Joachim Gabius, Sandra Amor, Bart J. L. Eggen, Susanne M. Kooistra
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-18 (2022)
Abstract Multiple sclerosis (MS) is a disease of the central nervous system that is characterized by inflammation and focal areas of demyelination, ultimately resulting in axonal degradation and neuronal loss. Several lines of evidence point towards
Externí odkaz:
https://doaj.org/article/e6a6235939ee4b9089024f9f8ef305b6
Autor:
Astrid M. Alsema, Qiong Jiang, Laura Kracht, Emma Gerrits, Marissa L. Dubbelaar, Anneke Miedema, Nieske Brouwer, Elly M. Hol, Jinte Middeldorp, Roland van Dijk, Maya Woodbury, Astrid Wachter, Simon Xi, Thomas Möller, Knut P. Biber, Susanne M. Kooistra, Erik W. G. M. Boddeke, Bart J. L. Eggen
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 13 (2020)
Microglia are the tissue-resident macrophages of the central nervous system (CNS). Recent studies based on bulk and single-cell RNA sequencing in mice indicate high relevance of microglia with respect to risk genes and neuro-inflammation in Alzheimer
Externí odkaz:
https://doaj.org/article/cf41d44a7139428b829cb962c615f345
Autor:
Wandert Schaafsma, Laura Bozal Basterra, Sabrina Jacobs, Nieske Brouwer, Peter Meerlo, Anne Schaafsma, Erik W.G.M. Boddeke, Bart J.L. Eggen
Publikováno v:
Neurobiology of Disease, Vol 106, Iss , Pp 291-300 (2017)
Maternal inflammation during pregnancy can have detrimental effects on embryonic development that persist during adulthood. However, the underlying mechanisms and insights in the responsible cell types are still largely unknown. Here we report the ef
Externí odkaz:
https://doaj.org/article/a7e7cff922b04238b3666fcdbfe18e67
Autor:
Zhuoran Yin, Divya D. Raj, Wandert Schaafsma, Roel A. van der Heijden, Susanne M. Kooistra, Aaffien C. Reijne, Xiaoming Zhang, Jill Moser, Nieske Brouwer, Peter Heeringa, Chun-Xia Yi, Gertjan van Dijk, Jon D. Laman, Erik W. G. M. Boddeke, Bart J. L. Eggen
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 11 (2018)
Rodent models of both aging and obesity are characterized by inflammation in specific brain regions, notably the corpus callosum, fornix, and hypothalamus. Microglia, the resident macrophages of the central nervous system, are important for brain dev
Externí odkaz:
https://doaj.org/article/5c32f625dbc44c8e89f5c3303c573f98
Autor:
Daniëlle C. Voshart, Takuya Oshima, Yuting Jiang, Gideon P. van der Linden, Anna P. Ainslie, Luiza Reali Nazario, Fleur van Buuren-Broek, Ayla C. Scholma, Nieske Brouwer, Jeffrey Sewdihal, Uilke Brouwer, Rob P. Coppes, Inge R. Holtman, Bart J.L. Eggen, Susanne M. Kooistra, Lara Barazzuol
SummaryMore than half of all brain tumour survivors experience debilitating and often progressive cognitive decline after treatment with radiotherapy. Microglia, the resident macrophages in the brain, have been implicated in this decline. In response
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f71502130d4c0f871db0431181da7158
https://doi.org/10.1101/2023.05.10.539581
https://doi.org/10.1101/2023.05.10.539581
Autor:
Nieske Brouwer, Thomas Möller, Jan Mulder, Maya E. Woodbury, Emma Gerrits, Peter Paul De Deyn, Knut Biber, Wilfred F. A. den Dunnen, Markus P. Kummer, Yannick Vermeiren, Erik Boddeke, Mirjam Lambourne, Susanne M. Kooistra, Bart J. L. Eggen
Publikováno v:
Acta Neuropathologica
Acta neuropathologica
Acta Neuropathologica 141 (2021) 5
Gerrits, E, Brouwer, N, Kooistra, S M, Woodbury, M E, Vermeiren, Y, Lambourne, M, Mulder, J, Kummer, M, Möller, T, Biber, K, Dunnen, W F A D, De Deyn, P P, Eggen, B J L & Boddeke, E W G M 2021, ' Distinct amyloid-β and tau-associated microglia profiles in Alzheimer’s disease ', Acta Neuropathologica, vol. 141, pp. 681–696 . https://doi.org/10.1007/s00401-021-02263-w
Acta Neuropathologica, 141(5), 681-696
Acta Neuropathologica. SPRINGER
Acta neuropathologica
Acta Neuropathologica 141 (2021) 5
Gerrits, E, Brouwer, N, Kooistra, S M, Woodbury, M E, Vermeiren, Y, Lambourne, M, Mulder, J, Kummer, M, Möller, T, Biber, K, Dunnen, W F A D, De Deyn, P P, Eggen, B J L & Boddeke, E W G M 2021, ' Distinct amyloid-β and tau-associated microglia profiles in Alzheimer’s disease ', Acta Neuropathologica, vol. 141, pp. 681–696 . https://doi.org/10.1007/s00401-021-02263-w
Acta Neuropathologica, 141(5), 681-696
Acta Neuropathologica. SPRINGER
Alzheimer’s disease (AD) is the most prevalent form of dementia and is characterized by abnormal extracellular aggregates of amyloid-β and intraneuronal hyperphosphorylated tau tangles and neuropil threads. Microglia, the tissue-resident macrophag
Autor:
Thecla A. van Wageningen, Emma Gerrits, Nieske Brouwer, John J. P. Brevé, Jeroen J. G. Geurts, Bart J. L. Eggen, H. W. G. M. (Erik) Boddeke, Anne-Marie van Dam
Publikováno v:
Brain Communications, 4(2):005. Oxford University Press
Brain Communications, 4(2):fcac005. Oxford University Press
van Wageningen, T A, Gerrits, E, Brouwer, N, Breve, J J P, Geurts, J J G, Eggen, B J L, Boddeke, H W G M E & van Dam, A-M 2022, ' Distinct gene expression in demyelinated white and grey matter areas of patients with multiple sclerosis ', Brain Communications, vol. 4, no. 2, 005 . https://doi.org/10.1093/braincomms/fcac005
van Wageningen, T A, Gerrits, E, Brouwer, N, Breve, J J P, Geurts, J J G, Eggen, B J L, Boddeke, H W G M & van Dam, A-M 2022, ' Distinct gene expression in demyelinated white and grey matter areas of patients with multiple sclerosis ', Brain Communications, vol. 4, no. 2, fcac005 . https://doi.org/10.1093/braincomms/fcac005
Brain Communications, 4(2):fcac005. Oxford University Press
van Wageningen, T A, Gerrits, E, Brouwer, N, Breve, J J P, Geurts, J J G, Eggen, B J L, Boddeke, H W G M E & van Dam, A-M 2022, ' Distinct gene expression in demyelinated white and grey matter areas of patients with multiple sclerosis ', Brain Communications, vol. 4, no. 2, 005 . https://doi.org/10.1093/braincomms/fcac005
van Wageningen, T A, Gerrits, E, Brouwer, N, Breve, J J P, Geurts, J J G, Eggen, B J L, Boddeke, H W G M & van Dam, A-M 2022, ' Distinct gene expression in demyelinated white and grey matter areas of patients with multiple sclerosis ', Brain Communications, vol. 4, no. 2, fcac005 . https://doi.org/10.1093/braincomms/fcac005
van Wageningen et al. present gene expression data of demyelinated and normal-appearing white and grey matter of multiple sclerosis leucocortical lesions. They find that grey matter lesions primarily feature gene expression indicative of a microglial