Výsledky vyhledávání - "Nienke M van de Velde"

Akademický článek

Givinostat for Becker muscular dystrophy: A randomized, placebo-controlled, double-blind study

Autor: Giacomo P. Comi, Erik H. Niks, Krista Vandenborne, Claudia M. Cinnante, Hermien E. Kan, Rebecca J. Willcocks, Daniele Velardo, Francesca Magri, Michela Ripolone, Jules J. van Benthem, Nienke M. van de Velde, Simone Nava, Laura Ambrosoli, Sara Cazzaniga, Paolo U. Bettica

Publikováno v: Frontiers in Neurology, Vol 14 (2023)

ObjectiveNo treatments are approved for Becker muscular dystrophy (BMD). This study investigated the efficacy and safety of givinostat, a histone deacetylase pan-inhibitor, in adults with BMD.MethodsMales aged 18–65 years with a diagnosis of BMD co

Externí odkaz: https://doaj.org/article/ef5313913e3541e8afd1fe92d354ed17

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Value of Global Longitudinal Strain for Identification and Monitoring of Left Ventricular Dysfunction in Becker Muscular Dystrophy

Autor: Erik H. Niks, Nina Ajmone Marsan, Jeroen J. Bax, Tea Gegenava, Nienke M van de Velde, A. A. W. Roest, Douwe E. Atsma, Steele C Butcher, Zaïda Koeks, Pietro Spitali

Publikováno v: American Journal of Cardiology, 162, 170-176. EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC

Cardiac involvement is the main cause of death in Becker muscular dystrophy (BMD). Identification of left ventricular (LV) function is crucial, but standard echocardiographic measurements such as LV ejection fraction (LVEF) might not be sensitive eno

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bc9bed046bd5c98c26bb82bed63e1ad
https://doi.org/10.1016/j.amjcard.2021.09.016

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Longitudinal Assessment of creatine kinase, creatine/creatinine(ratio), and myostatin as monitoring biomarkers in Becker muscular dystrophy

Autor: Nienke M. van de Velde, Zaïda Koeks, Mirko Signorelli, Nisha Verwey, Maurice Overzier, Jaap A. Bakker, Gautam Sajeev, James Signorovitch, Valeria Ricotti, Jan Verschuuren, Kristy Brown, Pietro Spitali, Erik H. Niks

Publikováno v: Neurology, 100(9), E975-E984. LIPPINCOTT WILLIAMS & WILKINS
Neurology

Background and ObjectivesThe slow and variable disease progression of Becker muscular dystrophy (BMD) urges the development of biomarkers to facilitate clinical trials. We explored changes in 3 muscle-enriched biomarkers in serum of patients with BMD

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3a57db93bedb6271d9c761dcf773bd2
https://hdl.handle.net/1887/3590525

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Diffusion-tensor magnetic resonance imaging captures increased skeletal muscle fibre diameters in Becker muscular dystrophy

Autor: Donnie Cameron, Tooba Abbassi‐Daloii, Laura G.M. Heezen, Nienke M. van de Velde, Zaïda Koeks, Thom T.J. Veeger, Melissa T. Hooijmans, Salma el Abdellaoui, Sjoerd G. van Duinen, Jan J.G.M. Verschuuren, Maaike van Putten, Annemieke Aartsma‐Rus, Vered Raz, Pietro Spitali, Erik H. Niks, Hermien E. Kan

Publikováno v: Journal of Cachexia, Sarcopenia and Muscle. Wiley-Blackwell

Background: Becker muscular dystrophy (BMD) is an X-linked disorder characterized by slow, progressive muscle damage and muscle weakness. Hallmarks include fibre-size variation and replacement of skeletal muscle with fibrous and adipose tissues, afte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f783c2c45339daec94d9e053953f5c19
https://doi.org/10.1002/jcsm.13242

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Association of Elbow Flexor MRI Fat Fraction With Loss of Hand-to-Mouth Movement in Patients With Duchenne Muscular Dystrophy

Autor: Erik H. Niks, Hermien E. Kan, Erik W. van Zwet, Jan J.G.M. Verschuuren, Karin J. Naarding, Imelda J. M. de Groot, Menno van der Holst, Nienke M van de Velde

Publikováno v: Neurology, 97, E1737-E1742
Neurology, 97, 17, pp. E1737-E1742
Neurology, 97(17), E1737-E1742. LIPPINCOTT WILLIAMS & WILKINS
Neurology
article-version (Version of Record) 3

Background and ObjectivesTo study the potential of quantitative MRI (qMRI) fat fraction (FF) as a biomarker in nonambulant patients with Duchenne muscular dystrophy (DMD), we assessed the additive predictive value of elbow flexor FF to age at loss of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::751ee7d230b2f47769488043e59611bb
https://doi.org/10.1212/wnl.0000000000012724

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Baseline fat fraction is a strong predictor of disease progression in Becker muscular dystrophy

Autor: Nienke M. Van de Velde, Jurriaan De Groot, Erik Niks, Melissa Hooijmans, Thom Veeger, Kevin Keene, Andrew Webb, Hermien Kan

Publikováno v: NMR in Biomedicine, 35(7). WILEY
NMR in biomedicine, 35(7):e4691. John Wiley and Sons Ltd

In Becker muscular dystrophy (BMD), muscle weakness progresses relatively slowly, with a highly variable rate among patients. This complicates clinical trials, as clinically relevant changes are difficult to capture within the typical duration of a t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82260761046e46703156a090db8abb84
http://hdl.handle.net/1887/3276366

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Characterization of patients with Becker muscular dystrophy by histology, magnetic resonance imaging, function, and strength assessments

Autor: Giacomo P. Comi, Erik H. Niks, Claudia M. Cinnante, Hermien E. Kan, Krista Vandenborne, Rebecca J. Willcocks, Daniele Velardo, Michela Ripolone, Jules J. van Benthem, Nienke M. van de Velde, Simone Nava, Laura Ambrosoli, Sara Cazzaniga, Paolo U. Bettica

Publikováno v: Muscle & Nerve. WILEY
Muscle & Nerve

Introduction/Aims Becker muscular dystrophy (BMD) is characterized by variable disease severity and progression, prompting the identification of biomarkers for clinical trials. We used data from an ongoing phase II study to provide a comprehensive ch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e7f4f876bdc57b0758e80894b15e5e2
https://pubmed.ncbi.nlm.nih.gov/34918368

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Selection approach to identify the optimal biomarker using quantitative muscle MRI and functional assessments in Becker muscular dystrophy

Autor: Erik W. van Zwet, Nienke M van de Velde, Hermien E. Kan, Kevin R Keene, Thom T.J. Veeger, Jan J.G.M. Verschuuren, Zaïda Koeks, Jan-Willem M Beenakker, Erik H. Niks, Iris Alleman, Aashley S.D. Sardjoe Mishre, Melissa T. Hooijmans

Publikováno v: Neurology, 97(5), E513-E522. LIPPINCOTT WILLIAMS & WILKINS
Neurology, 97(5), e513-e522. Lippincott Williams and Wilkins
Neurology
article-version (Version of Record) 3

ObjectiveTo identify the best quantitative fat–water MRI biomarker for disease progression of leg muscles in Becker muscular dystrophy (BMD) by applying a stepwise approach based on standardized response mean (SRM) over 24 months, correlations with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff716d20ff74a8dbdfb5e4c0827d95f8
https://n.neurology.org/content/neurology/97/5/e513.full.pdf

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Muscle architecture is associated with muscle fat replacement in Duchenne and Becker muscular dystrophies

Autor: Erik W. van Zwet, Hermien E. Kan, Melissa T. Hooijmans, Karin J. Naarding, Andrew G. Webb, Jurriaan H. de Groot, Erik H. Niks, Diaa Al Mohamad, Thom T.J. Veeger, Nienke M van de Velde

Publikováno v: Muscle & Nerve, 64(5), 576-584. WILEY
Muscle & nerve, 64(5), 576-584. John Wiley and Sons Inc.

Introduction/aims Duchenne and Becker muscular dystrophies (DMD and BMD, respectively) are characterized by fat replacement of different skeletal muscles in a specific temporal order. Given the structural role of dystrophin in skeletal muscle mechani

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::910ea969a3cfa9bc9d5ed75be9116b0d
https://pubmed.ncbi.nlm.nih.gov/34383334

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Preserved thenar muscles in non-ambulant Duchenne muscular dystrophy patients

Autor: Aashley S D Sardjoe Mishre, Jedrzej Burakiewicz, Jan J.G.M. Verschuuren, Kevin R Keene, Nienke M van de Velde, Thom T J Veeger, Karin J. Naarding, Erik H. Niks, Arina J Prins, Hermien E. Kan, Menno van der Holst

Publikováno v: Journal of Cachexia, Sarcopenia and Muscle, 12(3), 694-703. WILEY
Journal of Cachexia, Sarcopenia and Muscle
Journal of Cachexia, Sarcopenia and Muscle, Vol 12, Iss 3, Pp 694-703 (2021)

Background Clinical trials in Duchenne muscular dystrophy (DMD) focus primarily on ambulant patients. Results cannot be extrapolated to later disease stages due to a decline in targeted muscle tissue. In non-ambulant DMD patients, hand function is re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60162bdefeb1ce0431f95c58467ad319
https://doi.org/10.1002/jcsm.12711

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