Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Nienke Losekoot"'
Autor:
Godefridus J. Peters, Masakazu Fukushima, Paul P. Eijk, Bauke Ylstra, Richard J. Honeywell, Kees Smid, Auke D. Adema, Nienke Losekoot, Henk-Jan Prins, Irene V. Bijnsdorp, Olaf H. Temmink
Trifluorothymidine (TFT) is part of the novel oral formulation TAS-102, which is currently evaluated in phase II studies. Drug resistance is an important limitation of cancer therapy. The aim of the present study was to induce resistance to TFT in H6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ae2bf0ea06ae01c6fec69291c8b070d
https://doi.org/10.1158/1535-7163.c.6531774
https://doi.org/10.1158/1535-7163.c.6531774
Autor:
Godefridus J. Peters, Masakazu Fukushima, Paul P. Eijk, Bauke Ylstra, Richard J. Honeywell, Kees Smid, Auke D. Adema, Nienke Losekoot, Henk-Jan Prins, Irene V. Bijnsdorp, Olaf H. Temmink
Supplementary Data from Trifluorothymidine Resistance Is Associated with Decreased Thymidine Kinase and Equilibrative Nucleoside Transporter Expression or Increased Secretory Phospholipase A2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c33d9c0373858d6e8a91df2cdb7760b
https://doi.org/10.1158/1535-7163.22485105.v1
https://doi.org/10.1158/1535-7163.22485105.v1
Autor:
Richard J. Honeywell, Joseph Ciccolini, Nienke Losekoot, Cindy Serdjebi, M. Maulandi, M.C. Etienne-Grimaldi, Elisa Giovannetti, G.J. Peters, G. Milano
Publikováno v:
Nucleosides, Nucleotides and Nucleic Acids, 33(4-6), 403-412. Taylor and Francis Ltd.
Peters, G J, Honeywell, R J, Maulandi, M, Giovannetti, E, Losekoot, N, Etienne-Grimaldi, M C, Milano, G, Serdjebi, C & Ciccolini, J 2014, ' Selection of the Best Blood Compartment to Measure Cytidine Deaminase Activity to Stratify for Optimal Gemcitabine Or Cytarabine Treatment ', Nucleosides, Nucleotides and Nucleic Acids, vol. 33, no. 4-6, pp. 403-412 . https://doi.org/10.1080/15257770.2014.894196
Peters, G J, Honeywell, R J, Maulandi, M, Giovannetti, E, Losekoot, N, Etienne-Grimaldi, M C, Milano, G, Serdjebi, C & Ciccolini, J 2014, ' Selection of the Best Blood Compartment to Measure Cytidine Deaminase Activity to Stratify for Optimal Gemcitabine Or Cytarabine Treatment ', Nucleosides, Nucleotides and Nucleic Acids, vol. 33, no. 4-6, pp. 403-412 . https://doi.org/10.1080/15257770.2014.894196
Cytidine deaminase (CDA) plays a crucial role in the degradation of cytidine analogs, such as gemcitabine and cytarabine. Several studies showed that a low CDA activity is associated with more toxicity but a higher efficacy, while a high activity wil
Autor:
D.P. van Asseldonk, G.J. Peters, Nienke Losekoot, A.A. van Bodegraven, Margien L. Seinen, N. K. H. de Boer, Gerd Bouma, Kees Smid, Cjj Mulder
Publikováno v:
Seinen, M L, van Asseldonk, D P, de Boer, K H N, Losekoot, N, Smid, K, Mulder, C J J, Bouma, G, Peters, G J & van Bodegraven, A A 2013, ' The effect of allopurinol and low-dose thiopurine combination therapy on the activity of three pivotal thiopurine metabolizing enzymes: Results from a prospective pharmacological study ', Journal of Crohn's and Colitis, vol. 7, no. 10, pp. 812-819 . https://doi.org/10.1016/j.crohns.2012.12.006
Journal of Crohn's and Colitis, 7(10), 812-819. Elsevier
Journal of Crohn's and Colitis, 7(10), 812-819. Elsevier
Introduction Thiopurine therapy is often discontinued in inflammatory bowel disease (IBD) patients. The xanthine oxidase (XO) inhibitor allopurinol has previously shown to enhance thiopurine efficacy and to prevent adverse reactions, the mechanism of
Autor:
Nicolaas A. P. Franken, Lukas J.A. Stalpers, Hans M. Rodermond, Ahmed Güçlü, Suzanne Hovingh, Bregje van Oorschot, Nienke Losekoot, G. W. Barendsen, Albert A. Geldof
Publikováno v:
Oncology Reports, 29(6), 2175-2180. Spandidos Publications
Oncology reports, 29(6), 2175-2180. Spandidos Publications
Van Oorschot, B, Hovingh, S E, Rodermond, H, Guclu, A, Losekoot, N, Geldof, A A, Barendsen, G W, Stalpers, LJ & Franken, N A P 2013, ' Decay of gamma-H2AX foci correlates with potentially lethal damage repair in prostate cancer cells ', Oncology Reports, vol. 29, no. 6, pp. 2175-2180 . https://doi.org/10.3892/or.2013.2364
Oncology reports, 29(6), 2175-2180. Spandidos Publications
Van Oorschot, B, Hovingh, S E, Rodermond, H, Guclu, A, Losekoot, N, Geldof, A A, Barendsen, G W, Stalpers, LJ & Franken, N A P 2013, ' Decay of gamma-H2AX foci correlates with potentially lethal damage repair in prostate cancer cells ', Oncology Reports, vol. 29, no. 6, pp. 2175-2180 . https://doi.org/10.3892/or.2013.2364
To determine the relationship between ionizing radiation-induced levels of γ-H2AX foci and cell survival in cultured prostate cancer cell lines, three prostate cancer cell lines: LNCaP (wt TP53), DU145 (mut TP53) and PC3 (TP53 null), were studied. F
Autor:
Deog Joong Kim, Ietje Kathmann, Young Bok Lee, Chang-Ho Ahn, Godefridus J. Peters, Aric Orbach, Leonardo Vecchi, Nienke Losekoot, Kees Smid, Richard J. Honeywell, Eran Blaugrund, Osnat Ohne, Lak Shin Jeong, Dzjemma Sarkisjan
Publikováno v:
Peters, G J, Smid, K, Vecchi, L, Kathmann, I, Sarkisjan, D, Honeywell, R J, Losekoot, N, Ohne, O, Orbach, A, Blaugrund, E, Jeong, L S, Lee, Y B, Ahn, C H & Kim, D J 2013, ' Metabolism, mechanism of action and sensitivity profile of fluorocyclopentenylcytosine (RX-3117; TV-1360) ', Investigational New Drugs, vol. 31, no. 6, pp. 1444-1457 . https://doi.org/10.1007/s10637-013-0025-x
Investigational New Drugs, 31(6), 1444-1457. Kluwer Academic Publishers
Investigational New Drugs, 31(6), 1444-1457. Kluwer Academic Publishers
A novel cytidine analog fluorocyclopentenylcytosine (RX-3117; TV-1360) was characterized for its cytotoxicity in a 59-cell line panel and further characterized for cytotoxicity, metabolism and mechanism of action in 15 additional cancer cell lines, i
Autor:
Nienke Losekoot, Gerrit Jansen, Godefridus J. Peters, Jan Hendrik Hooijberg, Clara Lemos, Ietje Kathmann
Publikováno v:
Pteridines, Vol 24, Iss 1, Pp 81-86 (2013)
Pteridines, 24(1), 81-86. International Society of Pteridinology
Peters, G J, Kathmann, I, Lemos, C, Hooijberg, J H, Losekoot, N & Jansen, G 2013, ' Folate homeostasis of cancer cells affects sensitivity to not only antifolates but also other non-folate drugs: effect of MRP expression ', Pteridines, vol. 24, no. 1, pp. 81-86 . https://doi.org/10.1515/pterid-2013-0019
Pteridines, 24(1), 81-86. International Society of Pteridinology
Peters, G J, Kathmann, I, Lemos, C, Hooijberg, J H, Losekoot, N & Jansen, G 2013, ' Folate homeostasis of cancer cells affects sensitivity to not only antifolates but also other non-folate drugs: effect of MRP expression ', Pteridines, vol. 24, no. 1, pp. 81-86 . https://doi.org/10.1515/pterid-2013-0019
Sensitivity to antifolates can be decreased by endogenous or exogenous folates. Leucovorin protects cancer patients against toxicity of the dihydrofolate reductase inhibitor methotrexate (MTX), while folic acid is used to protect rheumatoid arthritis
Autor:
Richard J. Honeywell, A.D. Adema, Finn Myhren, Marit Liland Sandvold, Godefridus J. Peters, Nienke Losekoot, Henk M.W. Verheul, Kees Smid
Publikováno v:
Investigational New Drugs
Investigational New Drugs, 30(5), 1908-1916. Kluwer Academic Publishers
Adema, A D, Smid, K, Losekoot, N, Honeywell, R J, Verheul, H M W, Myhren, F, Sandvold, M & Peters, G J 2012, ' Metabolism and accumulation of the lipophilic deoxynucleoside analogs elacytarabine and CP-4126 ', Investigational New Drugs, vol. 30, no. 5, pp. 1908-1916 . https://doi.org/10.1007/s10637-011-9756-8
Investigational New Drugs, 30(5), 1908-1916. Kluwer Academic Publishers
Adema, A D, Smid, K, Losekoot, N, Honeywell, R J, Verheul, H M W, Myhren, F, Sandvold, M & Peters, G J 2012, ' Metabolism and accumulation of the lipophilic deoxynucleoside analogs elacytarabine and CP-4126 ', Investigational New Drugs, vol. 30, no. 5, pp. 1908-1916 . https://doi.org/10.1007/s10637-011-9756-8
Summary Cytarabine (ara-C) and gemcitabine (dFdC) are commonly used anticancer drugs, which depend on the equilibrative (ENT) and concentrative-nucleoside-transporters to enter the cell. To bypass transport-related drug resistance, lipophilic derivat
Autor:
Richard J. Honeywell, Godefridus J. Peters, Masakazu Fukushima, Nienke Losekoot, Paul P. Eijk, Kees Smid, Olaf H. Temmink, Auke D. Adema, Irene V. Bijnsdorp, Bauke Ylstra, Henk-Jan Prins
Publikováno v:
Temmink, O H, Bijnsdorp, I V, Prins, H J, Losekoot, N, Adema, A D, Smid, K, Honeywell, R J, Ylstra, B, Eijk, P P, Fukushima, M & Peters, G J 2010, ' Trifluorothymidine Resistance Is Associated with Decreased Thymidine Kinase and Equilibrative Nucleoside Transporter Expression or Increased Secretory Phospholipase A2 ', Molecular Cancer Therapeutics, vol. 9, no. 4, pp. 1047-1057 . https://doi.org/10.1158/1535-7163.MCT-09-0932
Molecular Cancer Therapeutics, 9(4), 1047-1057. American Association for Cancer Research Inc.
Molecular Cancer Therapeutics, 9(4), 1047-1057. American Association for Cancer Research Inc.
Trifluorothymidine (TFT) is part of the novel oral formulation TAS-102, which is currently evaluated in phase II studies. Drug resistance is an important limitation of cancer therapy. The aim of the present study was to induce resistance to TFT in H6
Autor:
Egbert F. Smit, Henk M.W. Verheul, Elisa Giovannetti, Joline S.W. Lind, Richard J. Honeywell, Carmelo Tibaldi, K. Yarzadah, Nienke Losekoot, G.J. Peters, Maudy Walraven
Publikováno v:
Honeywell, R J, Yarzadah, K, Giovannetti, E, Losekoot, N, Smit, E F, Walraven, M, Lind, J S W, Tibaldi, C, Verheul, H M W & Peters, G J 2010, ' Simple and selective method for the determination of various tyrosine kinase inhibitors used in the clinical setting by liquid chromatography tandem mass spectrometry ', Journal of Chromatography B, vol. 878, no. 15-16, pp. 1059-1068 . https://doi.org/10.1016/j.jchromb.2010.03.010
Journal of Chromatography B, 878(15-16), 1059-1068. Elsevier
Journal of Chromatography B, 878(15-16), 1059-1068. Elsevier
A fast, sensitive, universal and accurate method for the determination of four different tyrosine kinase inhibitors from biological material was developed using LC-MS/MS techniques. Utilizing a simple protein precipitation with acetonitrile a 20 micr