Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Nien-Jung Chen"'
Autor:
Yen-Han Tseng, Sheng-Wei Pan, Jhong-Ru Huang, Chang-Ching Lee, Jung-Jyh Hung, Po-Kuei Hsu, Nien-Jung Chen, Wei-Juin Su, Yuh-Min Chen, Jia-Yih Feng
Publikováno v:
Microbial Cell, Vol 11, p 278 (2024)
The PD-1/PD-L1 pathway plays a pivotal role in T cell activity and is involved in the pathophysiology of Mycobacterium tuberculosis (MTB) infection. DNA methylation is a mechanism that modulates PD-L1 expression in cancer cells. However, its effect o
Externí odkaz:
https://doaj.org/article/0d13d1073e114f1b828ead3170573d78
Autor:
Hao-Yuan Wang, Fu-Chen Yang, Ching-Fen Yang, Yao-Chung Liu, Po-Shen Ko, Chien-Jung Li, Chun-Kuang Tsai, Yi-Lin Chung, Nien-Jung Chen
Publikováno v:
Experimental Hematology & Oncology, Vol 12, Iss 1, Pp 1-16 (2023)
Abstract Introduction Circulating monocytic myeloid-derived suppressive cells (M-MDSCs) are implicated as a poor prognostic factor and cause CAR T-cell failure in diffuse large B-cell lymphoma (DLBCL). Triggering receptors expressed on myeloid cells
Externí odkaz:
https://doaj.org/article/2e5508dfc5244e1788f61acbf60eb93d
Autor:
Tyng-An Zhou, Hsuan-Po Hsu, Yueh-Hua Tu, Hui-Kuei Cheng, Chih-Yu Lin, Nien-Jung Chen, Jin-Wu Tsai, Ellen A Robey, Hsuan-Cheng Huang, Chia-Lin Hsu, Ivan L Dzhagalov
Publikováno v:
eLife, Vol 11 (2022)
Tissue-resident macrophages are essential to protect from pathogen invasion and maintain organ homeostasis. The ability of thymic macrophages to engulf apoptotic thymocytes is well appreciated, but little is known about their ontogeny, maintenance, a
Externí odkaz:
https://doaj.org/article/e2be2a7d17c844db955442ecde1ea243
Autor:
Wei-Cheng Tseng, Pei-Ying Lee, Ming-Tsun Tsai, Fu-Pang Chang, Nien-Jung Chen, Chiang-Ting Chien, Shih-Chieh Hung, Der-Cherng Tarng
Publikováno v:
Stem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-22 (2021)
Abstract Background Acute kidney injury (AKI) is an emerging global healthcare issue without effective therapy yet. Autophagy recycles damaged organelles and helps maintain tissue homeostasis in acute renal ischemia-reperfusion (I/R) injury. Hypoxic
Externí odkaz:
https://doaj.org/article/2db882749f6745dab40c445a66045281
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
BackgroundDecoy receptor 3 (DcR3) belongs to the tumor necrosis factor (TNF) receptor superfamily and neutralizes TNF ligands, including FasL and TRAIL, to prevent T activation during T-cell priming. However, the cellular mechanisms underlying acute
Externí odkaz:
https://doaj.org/article/29f78f4249c34bf8b79eebe7bd043cf6
Autor:
Yi-Ju Chou, Ching-Cheng Lin, Ivan Dzhagalov, Nien-Jung Chen, Chao-Hsiung Lin, Chun-Cheng Lin, Szu-Ting Chen, Kuo-Hsin Chen, Shu-Ling Fu
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Abstract Toll-like receptors (TLRs) play crucial roles in host immune defenses. Recently, TLR-mediated autophagy is reported to promote immune responses via increasing antigen processing and presentation in antigen presenting cells. The present study
Externí odkaz:
https://doaj.org/article/1b2b59d6d750445faa8b12ddd17b55b0
Publikováno v:
Journal of Biomedical Science, Vol 26, Iss 1, Pp 1-14 (2019)
Abstract Background Triggering receptor expressed on myeloid cells-1 (TREM-1) is highly expressed on macrophages in inflamed intestines and reportedly promotes inflammatory bowel disease (IBD) by augmenting pro-inflammatory responses. To study the me
Externí odkaz:
https://doaj.org/article/b27b150d37914016bd91b1135fcb3ebf
Autor:
Sheng-Wei Pan, Chin-Chung Shu, Jhong-Ru Huang, Chang-Ching Lee, Yen-Han Tseng, Jung-Jyh Hung, Po-Kuei Hsu, Nien-Jung Chen, Wei-Juin Su, Jia-Yih Feng, Yuh-Min Chen
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 3, p 1619 (2022)
The PD-1/PD-L1 pathway is critical in T cell biology; however, the role of the PD-1/PD-L1 pathway in clinical characteristics and treatment outcomes in pulmonary tuberculosis (PTB) patients is unclear. We prospectively enrolled PTB, latent TB infecti
Externí odkaz:
https://doaj.org/article/2307f281c39d441d9276cfa971d9a58e
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 17, p 5966 (2020)
Mounting evidence indicates that an increase in histone deacetylation contributes to renal fibrosis. Although inhibition of histone deacetylase (HDAC) can reduce the extent of fibrosis, whether HDAC inhibitors exert the antifibrotic effect through mo
Externí odkaz:
https://doaj.org/article/396f0d64b5ac473c9fff9c3b61cc0de5
Nintedanib Reduces Neutrophil Chemotaxis via Activating GRK2 in Bleomycin-Induced Pulmonary Fibrosis
Autor:
Wei-Chih Chen, Nien-Jung Chen, Hsin-Pai Chen, Wen-Kuang Yu, Vincent Yi-Fong Su, Hao Chen, Huai-Hsuan Wu, Kuang-Yao Yang
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 13, p 4735 (2020)
Neutrophils are involved in the alveolitis of idiopathic pulmonary fibrosis (IPF). However, their pathogenic mechanisms are still poorly understood. Nintedanib has antifibrotic and anti-inflammatory activity in IPF. This study aimed to investigate th
Externí odkaz:
https://doaj.org/article/cd688deb4e7b40ce86db7bb65d92a707