Zobrazeno 1 - 10
of 89
pro vyhledávání: '"Nien‐Pei Tsai"'
Autor:
Yuxin Wang, Matthew Chae, Teak‐Jung Oh, Kangqiang Qiu, Kritika Mehta, Adrian Tan, Nien‐Pei Tsai, Donglu Shi, Kai Zhang, Jiajie Diao
Publikováno v:
Smart Medicine, Vol 3, Iss 3, Pp n/a-n/a (2024)
Abstract Bio‐waste is a side product of biomedical research containing carbon, which can be utilized for developing carbon dots (CDs). CDs are known to be useful for a variety of applications because of their unique photoluminescence, low toxicity,
Externí odkaz:
https://doaj.org/article/5c453deb12914b16b2e50bdaea9556c4
Autor:
Vipendra Kumar, Kwan Young Lee, Anirudh Acharya, Matthew S Babik, Catherine A Christian-Hinman, Justin S Rhodes, Nien-Pei Tsai
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 3, Pp 506-522 (2024)
Abstract Fragile X syndrome (FXS) is the leading cause of inherited autism and intellectual disabilities. Aberrant protein synthesis due to the loss of fragile X messenger ribonucleoprotein (FMRP) is the major defect in FXS, leading to a plethora of
Externí odkaz:
https://doaj.org/article/b326dbbf75824151a5fca593719224e0
Autor:
Brian C. Baculis, Harish Kesavan, Amanda C. Weiss, Edward H. Kim, Gregory C. Tracy, Wenhao Ouyang, Nien-Pei Tsai, Hee Jung Chung
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
Homeostatic plasticity encompasses the mechanisms by which neurons stabilize their synaptic strength and excitability in response to prolonged and destabilizing changes in their network activity. Prolonged activity blockade leads to homeostatic scali
Externí odkaz:
https://doaj.org/article/fcb24ce855bb47faa1f71d7609964866
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 14 (2022)
Fragile X Syndrome (FXS) is a leading inherited cause of autism and intellectual disability, resulting from a mutation in the FMR1 gene and subsequent loss of its protein product FMRP. Despite this simple genetic origin, FXS is a phenotypically compl
Externí odkaz:
https://doaj.org/article/a052d5e9be10403798c6e5054370e552
Publikováno v:
Neurobiology of Disease, Vol 158, Iss , Pp 105450- (2021)
Imbalanced neuronal excitability homeostasis is commonly observed in patients with fragile X syndrome (FXS) and the animal model of FXS, the Fmr1 KO. While alterations of neuronal intrinsic excitability and synaptic activity at the steady state in FX
Externí odkaz:
https://doaj.org/article/466fbf51d1614f10a86fbe0227d94175
Autor:
Eung Chang Kim, Jiaren Zhang, Weilun Pang, Shuwei Wang, Kwan Young Lee, John P. Cavaretta, Jennifer Walters, Erik Procko, Nien-Pei Tsai, Hee Jung Chung
Publikováno v:
Neurobiology of Disease, Vol 118, Iss , Pp 76-93 (2018)
Neuronal Kv7/KCNQ channels are voltage-gated potassium channels composed of Kv7.2/KCNQ2 and Kv7.3/KCNQ3 subunits. Enriched at the axonal membrane, they potently suppress neuronal excitability. De novo and inherited dominant mutations in Kv7.2 cause e
Externí odkaz:
https://doaj.org/article/372cf4aa38974527be62f6235c53539e
Publikováno v:
PLoS Genetics, Vol 15, Iss 9, p e1008364 (2019)
Seizures can induce endoplasmic reticulum (ER) stress, and sustained ER stress contributes to neuronal death after epileptic seizures. Despite the recent debate on whether inhibiting ER stress can reduce neuronal death after seizures, whether and how
Externí odkaz:
https://doaj.org/article/cdbc06f2547640848eab6aeb40b04cf0
Publikováno v:
PLoS Genetics, Vol 13, Iss 2, p e1006634 (2017)
The neural precursor cell expressed developmentally down-regulated gene 4-2, Nedd4-2, is an epilepsy-associated gene with at least three missense mutations identified in epileptic patients. Nedd4-2 encodes a ubiquitin E3 ligase that has high affinity
Externí odkaz:
https://doaj.org/article/73230d764dbf49f1bea48f9234d21df7
Autor:
Julia R. Wilkerson, Nien-Pei Tsai, Marina A. Maksimova, Hao Wu, Nicole P. Cabalo, Kristofer W. Loerwald, Jason B. Dictenberg, Jay R. Gibson, Kimberly M. Huber
Publikováno v:
Cell Reports, Vol 7, Iss 5, Pp 1589-1600 (2014)
Experience refines synaptic connectivity through neural activity-dependent regulation of transcription factors. Although activity-dependent regulation of transcription factors has been well described, it is unknown whether synaptic activity and local
Externí odkaz:
https://doaj.org/article/3f9656a8c4d043f39c85f44b977de992
Publikováno v:
PLoS ONE, Vol 3, Iss 7, p e2658 (2008)
Receptor interacting protein 140 (RIP140) is a versatile transcriptional co-repressor that plays roles in diverse metabolic processes including fat accumulation in adipocytes. Previously we identified three methylated arginine residues in RIP140, whi
Externí odkaz:
https://doaj.org/article/5bc074aeaded44d784a993f15373797b