Zobrazeno 1 - 10
of 9 068
pro vyhledávání: '"Nieminen, P."'
Publikováno v:
Methods Inf Med 2024; 63(01/02): 035-051
Background: Synthetic data has been proposed as a solution for sharing anonymized versions of sensitive biomedical datasets. Ideally, synthetic data should preserve the structure and statistical properties of the original data, while protecting the p
Externí odkaz:
http://arxiv.org/abs/2403.13612
Autor:
Fedik Rahimov, Pekka Nieminen, Priyanka Kumari, Emma Juuri, Tiit Nikopensius, Kitt Paraiso, Jakob German, Antti Karvanen, Mart Kals, Abdelrahman G. Elnahas, Juha Karjalainen, Mitja Kurki, Aarno Palotie, FinnGen, Estonian Biobank Research Team, Arja Heliövaara, Tõnu Esko, Sakari Jukarainen, Priit Palta, Andrea Ganna, Anjali P. Patni, Daniel Mar, Karol Bomsztyk, Julie Mathieu, Hannele Ruohola-Baker, Axel Visel, Walid D. Fakhouri, Brian C. Schutte, Robert A. Cornell, David P. Rice
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract In Finland, the frequency of isolated cleft palate (CP) is higher than that of isolated cleft lip with or without cleft palate (CL/P). This trend contrasts to that in other European countries but its genetic underpinnings are unknown. We con
Externí odkaz:
https://doaj.org/article/deb6024dc0564416a196dc00f1b96ded
Autor:
Juan C. Landoni, Semin Erkul, Tuomas Laalo, Steffi Goffart, Riikka Kivelä, Karlo Skube, Anni I. Nieminen, Sara A. Wickström, James Stewart, Anu Suomalainen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract High mitochondrial DNA (mtDNA) amount has been reported to be beneficial for resistance and recovery of metabolic stress, while increased mtDNA synthesis activity can drive aging signs. The intriguing contrast of these two mtDNA boosting out
Externí odkaz:
https://doaj.org/article/abaa7a8f0e33491a807e68fa7bc5e122
Knee Osteoarthritis (KOA) is a highly prevalent chronic musculoskeletal condition with no currently available treatment. The manifestation of KOA is heterogeneous and prediction of its progression is challenging. Current literature suggests that the
Externí odkaz:
http://arxiv.org/abs/2307.00873
Publikováno v:
Livers, Vol 4, Iss 3, Pp 333-351 (2024)
Overdose of acetaminophen (APAP) produces fulminant hepatic necrosis. The underlying mechanism of APAP hepatotoxicity involves mitochondrial dysfunction, including mitochondrial oxidant stress and the onset of mitochondrial permeability transition (M
Externí odkaz:
https://doaj.org/article/a4f6a251e7eb455597d007a3ff08d8c9
Autor:
Johanna Matilainen, Viivi Berg, Maija Vaittinen, Ulla Impola, Anne-Mari Mustonen, Ville Männistö, Marjo Malinen, Veera Luukkonen, Natalia Rosso, Tanja Turunen, Pirjo Käkelä, Silvia Palmisano, Uma Thanigai Arasu, Sanna P. Sihvo, Niina Aaltonen, Kai Härkönen, Andrea Caddeo, Dorota Kaminska, Päivi Pajukanta, Minna U. Kaikkonen, Claudio Tiribelli, Reijo Käkelä, Saara Laitinen, Jussi Pihlajamäki, Petteri Nieminen, Kirsi Rilla
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-20 (2024)
Abstract Background Obesity is a worldwide epidemic characterized by adipose tissue (AT) inflammation. AT is also a source of extracellular vesicles (EVs) that have recently been implicated in disorders related to metabolic syndrome. However, our und
Externí odkaz:
https://doaj.org/article/ceb5613430cf4656a79cba7215ebe4ee
Autor:
Nina Höglund, Heini Rossi, Hanna-Maaria Javela, Sanna Oikari, Petteri Nieminen, Anne-Mari Mustonen, Niina Airas, Vesa Kärjä, Anna Mykkänen
Publikováno v:
BMC Veterinary Research, Vol 20, Iss 1, Pp 1-11 (2024)
Abstract Background Equine asthma (EA) is a chronic lower airway inflammation that leads to structural and functional changes. Hyaluronic acid (HA) has crucial functions in the extracellular matrix homeostasis and inflammatory mediator activity. HA c
Externí odkaz:
https://doaj.org/article/ac89b01b76b74a57a1d70b0ca1792183
Autor:
Sebastian Heinzel, Jenna Jureczek, Veera Kainulainen, Anni I. Nieminen, Ulrike Suenkel, Anna-Katharina von Thaler, Christoph Kaleta, Gerhard W. Eschweiler, Kathrin Brockmann, Velma T. E. Aho, Petri Auvinen, Walter Maetzler, Daniela Berg, Filip Scheperjans
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Fecal calprotectin is an established marker of gut inflammation in inflammatory bowel disease (IBD). Elevated levels of fecal calprotectin as well as gut microbial dysbiosis have also been observed in other clinical conditions. However, syst
Externí odkaz:
https://doaj.org/article/a46199f195e744deaee36af9c329bc9e
Autor:
Linja, Joakim, Hämäläinen, Joonas, Pihlajamäki, Antti, Nieminen, Paavo, Malola, Sami, Häkkinen, Hannu, Kärkkäinen, Tommi
Molecular-level understanding of the interactions between the constituents of an atomic structure is essential for designing novel materials in various applications. This need goes beyond the basic knowledge of the number and types of atoms, their ch
Externí odkaz:
http://arxiv.org/abs/2303.09453
Publikováno v:
Phys. Rev. B, vol. 107, 174524 (2023)
Using an atomistic tight-binding model, we study the characteristics of a Josephson junction formed by monolayers of MoS$_2$ sandwiched between Pb superconducting electrodes. We derive and apply Green's function-based formulation to compute the Josep
Externí odkaz:
http://arxiv.org/abs/2302.06645