Gliflozins, sucrose and flavonoids are allosteric activators of lecithin-cholesterol acyltransferase.

Autor: Niemelä, Akseli¹ (AUTHOR) akseli.niemela@helsinki.fi, Giorgi, Laura¹ (AUTHOR), Nouri, Sirine¹ (AUTHOR), Yurttaş, Betül² (AUTHOR), Rauniyar, Khushbu¹ (AUTHOR), Jeltsch, Michael¹ (AUTHOR), Koivuniemi, Artturi¹ (AUTHOR) artturi.koivuniemi@helsinki.fi

Publikováno v: Scientific Reports. 10/30/2024, Vol. 14 Issue 1, p1-9. 9p.

Systematic evaluation of lecithin:Cholesterol acyltransferase binding sites in apolipoproteins via peptide based nanodiscs: Regulatory role of charged residues at positions 4 and 7.

Autor: Niemelä, Akseli¹ (AUTHOR) akseli.niemela@helsinki.fi, Koivuniemi, Artturi¹ (AUTHOR)

Publikováno v: PLoS Computational Biology. 5/28/2024, Vol. 20 Issue 5, p1-22. 22p.

Positive allosteric modulators of lecithin: Cholesterol acyltransferase adjust the orientation of the membrane-binding domain and alter its spatial free energy profile.

Autor: Niemelä, Akseli¹ (AUTHOR), Koivuniemi, Artturi¹ (AUTHOR) artturi.koivuniemi@helsinki.fi

Publikováno v: PLoS Computational Biology. 3/15/2021, p1-16. 16p. 5 Diagrams, 1 Chart, 1 Graph.

Molecular Insights on Successful Reconstitution of Freeze-Dried Nanofibrillated Cellulose Hydrogel.

Autor: Koivunotko E; Division of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, 00014 Helsinki, Finland., Merivaara A; Division of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, 00014 Helsinki, Finland., Niemelä A; Division of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, 00014 Helsinki, Finland., Valkonen S; Division of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, 00014 Helsinki, Finland., Manninen K; Division of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, 00014 Helsinki, Finland., Mäkinen H; Department of Physics, University of Helsinki, P.O. Box 64, 00014 Helsinki, Finland., Viljanen M; Department of Physics, University of Helsinki, P.O. Box 64, 00014 Helsinki, Finland., Svedström K; Department of Physics, University of Helsinki, P.O. Box 64, 00014 Helsinki, Finland., Diaz A; Paul Scherrer Institute, Forschungsstrasse 111, 5232 Villigen, PSI, Switzerland., Holler M; Paul Scherrer Institute, Forschungsstrasse 111, 5232 Villigen, PSI, Switzerland., Zini J; Division of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, 00014 Helsinki, Finland., Paasonen L; UPM Biomedicals, UPM-Kymmene Corporation, 00100 Helsinki, Finland., Korhonen O; School of Phamacy, University of Eastern Finland, 70210 Kuopio, Finland., Huotari S; Department of Physics, University of Helsinki, P.O. Box 64, 00014 Helsinki, Finland., Koivuniemi A; Division of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, 00014 Helsinki, Finland., Yliperttula M; Division of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, 00014 Helsinki, Finland.

Publikováno v: ACS applied bio materials [ACS Appl Bio Mater] 2021 Sep 20; Vol. 4 (9), pp. 7157-7167. Date of Electronic Publication: 2021 Sep 01.