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Akademický článek

The Effect of Deuteration and Homologation of the Lactam Ring of Nirmatrelvir on Its Biochemical Properties and Oxidative Metabolism.

Autor: Arutyunova E; Department of Biochemistry, University of Alberta, Edmonton, AB T6G 2H7, Canada.; Li Ka Shing Institute of Virology, University of Alberta, Edmonton, AB T6G 2E1, Canada., Belovodskiy A; Li Ka Shing Applied Virology Institute, University of Alberta, Edmonton, AB T6G 2E1, Canada.; Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB T6G 2E1, Canada., Chen P; Department of Biochemistry, University of Alberta, Edmonton, AB T6G 2H7, Canada.; Li Ka Shing Institute of Virology, University of Alberta, Edmonton, AB T6G 2E1, Canada., Khan MB; Department of Biochemistry, University of Alberta, Edmonton, AB T6G 2H7, Canada., Joyce M; Li Ka Shing Institute of Virology, University of Alberta, Edmonton, AB T6G 2E1, Canada.; Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB T6G 2E1, Canada., Saffran H; Li Ka Shing Institute of Virology, University of Alberta, Edmonton, AB T6G 2E1, Canada.; Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB T6G 2E1, Canada., Lu J; Department of Biochemistry, University of Alberta, Edmonton, AB T6G 2H7, Canada.; Li Ka Shing Institute of Virology, University of Alberta, Edmonton, AB T6G 2E1, Canada., Turner Z; Department of Biochemistry, University of Alberta, Edmonton, AB T6G 2H7, Canada., Bai B; Li Ka Shing Applied Virology Institute, University of Alberta, Edmonton, AB T6G 2E1, Canada.; Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB T6G 2E1, Canada., Lamer T; Department of Chemistry, University of Alberta, Edmonton, AB T6G 2G2, Canada., Young HS; Department of Biochemistry, University of Alberta, Edmonton, AB T6G 2H7, Canada., Vederas JC; Department of Chemistry, University of Alberta, Edmonton, AB T6G 2G2, Canada., Tyrrell DL; Li Ka Shing Institute of Virology, University of Alberta, Edmonton, AB T6G 2E1, Canada.; Li Ka Shing Applied Virology Institute, University of Alberta, Edmonton, AB T6G 2E1, Canada.; Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB T6G 2E1, Canada., Lemieux MJ; Department of Biochemistry, University of Alberta, Edmonton, AB T6G 2H7, Canada.; Li Ka Shing Institute of Virology, University of Alberta, Edmonton, AB T6G 2E1, Canada., Nieman JA; Li Ka Shing Applied Virology Institute, University of Alberta, Edmonton, AB T6G 2E1, Canada.; Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB T6G 2E1, Canada.

Publikováno v: ACS bio & med chem Au [ACS Bio Med Chem Au] 2023 Nov 15; Vol. 3 (6), pp. 528-541. Date of Electronic Publication: 2023 Nov 15 (Print Publication: 2023).

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Akademický článek

Deuteration for Metabolic Stabilization of SARS-CoV-2 Inhibitors GC373 and Nirmatrelvir.

Autor: Van Oers TJ; Department of Chemistry, University of Alberta, Edmonton, Alberta T6G 2G2, Canada., Piercey A; Department of Chemistry, McGill University, Montreal, Quebec H3A 0B8, Canada., Belovodskiy A; Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta T6G 2E1, Canada., Reiz B; Department of Chemistry, University of Alberta, Edmonton, Alberta T6G 2G2, Canada., Donnelly BL; Department of Chemistry, University of Alberta, Edmonton, Alberta T6G 2G2, Canada., Vuong W; Department of Chemistry, University of Alberta, Edmonton, Alberta T6G 2G2, Canada., Lemieux MJ; Department of Biochemistry, University of Alberta, Edmonton, Alberta T6G 2H7, Canada., Nieman JA; Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta T6G 2E1, Canada., Auclair K; Department of Chemistry, McGill University, Montreal, Quebec H3A 0B8, Canada., Vederas JC; Department of Chemistry, University of Alberta, Edmonton, Alberta T6G 2G2, Canada.

Publikováno v: Organic letters [Org Lett] 2023 Aug 11; Vol. 25 (31), pp. 5885-5889. Date of Electronic Publication: 2023 Jul 31.

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Akademický článek

Inhibition of the hERG potassium ion channel by different non-nucleoside human cytomegalovirus polymerase antiviral inhibitor series and the exploration of variations on a pyrroloquinoline core to reduce cardiotoxicity potential.

Autor: Srinivas Kandadai A; Li Ka Shing Applied Virology Institute and Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta T6G 2E1, Canada., Bai B; Li Ka Shing Applied Virology Institute and Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta T6G 2E1, Canada., Rahim M; Rane Pharmaceuticals, Inc., Edmonton, Alberta T6E 5V2, Canada., Lin F; WuXi AppTec (Shanghai) Co., Ltd., Shanghai 200131, China., Gu Z; WuXi AppTec (Shanghai) Co., Ltd., Shanghai 200131, China., Qi X; WuXi AppTec (Shanghai) Co., Ltd., Shanghai 200131, China., Zhang X; WuXi AppTec (Shanghai) Co., Ltd., Shanghai 200131, China., Dong H; WuXi AppTec (Shanghai) Co., Ltd., Shanghai 200131, China., Chen Y; WuXi AppTec (Shanghai) Co., Ltd., Shanghai 200131, China., Shen J; ProFoldin, 10 Technology Drive, Suite 40, Hudson, MA 01749-2791, USA., Nieman JA; Li Ka Shing Applied Virology Institute and Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta T6G 2E1, Canada. Electronic address: jnieman@ualberta.ca.

Publikováno v: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2023 May 01; Vol. 85, pp. 117276. Date of Electronic Publication: 2023 Apr 05.

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Akademický článek

SARS-CoV-2 M ^pro Protease Variants of Concern Display Altered Viral Substrate and Cell Host Target Galectin-8 Processing but Retain Sensitivity toward Antivirals.

Autor: Chen SA; Department of Biochemistry, University of Alberta, Edmonton, Alberta T6G 2H7, Canada.; Li Ka Shing Institute of Virology, University of Alberta, Edmonton, Alberta T6G 2E1, Canada., Arutyunova E; Department of Biochemistry, University of Alberta, Edmonton, Alberta T6G 2H7, Canada.; Li Ka Shing Institute of Virology, University of Alberta, Edmonton, Alberta T6G 2E1, Canada., Lu J; Department of Biochemistry, University of Alberta, Edmonton, Alberta T6G 2H7, Canada.; Li Ka Shing Institute of Virology, University of Alberta, Edmonton, Alberta T6G 2E1, Canada., Khan MB; Department of Biochemistry, University of Alberta, Edmonton, Alberta T6G 2H7, Canada., Rut W; Department of Chemical Biology and Bioimaging, Wroclaw University of Science and Technology, Wroclaw, 50-370, Poland., Zmudzinski M; Department of Chemical Biology and Bioimaging, Wroclaw University of Science and Technology, Wroclaw, 50-370, Poland., Shahbaz S; Department of Dentistry & Dental Hygiene, University of Alberta, Edmonton, Alberta T6G 2E1, Canada., Iyyathurai J; Department of Biochemistry, University of Alberta, Edmonton, Alberta T6G 2H7, Canada.; Li Ka Shing Institute of Virology, University of Alberta, Edmonton, Alberta T6G 2E1, Canada., Moussa EW; Department of Biochemistry, University of Alberta, Edmonton, Alberta T6G 2H7, Canada., Turner Z; Department of Biochemistry, University of Alberta, Edmonton, Alberta T6G 2H7, Canada., Bai B; Li Ka Shing Applied Virology Institute, University of Alberta, Edmonton, Alberta T6G 2E1, Canada.; Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta T6G 2E1, Canada., Lamer T; Department of Chemistry, University of Alberta, Edmonton, Alberta T6G 2G2, Canada., Nieman JA; Li Ka Shing Applied Virology Institute, University of Alberta, Edmonton, Alberta T6G 2E1, Canada.; Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta T6G 2E1, Canada., Vederas JC; Department of Chemistry, University of Alberta, Edmonton, Alberta T6G 2G2, Canada., Julien O; Department of Biochemistry, University of Alberta, Edmonton, Alberta T6G 2H7, Canada., Drag M; Department of Chemical Biology and Bioimaging, Wroclaw University of Science and Technology, Wroclaw, 50-370, Poland., Elahi S; Department of Dentistry & Dental Hygiene, University of Alberta, Edmonton, Alberta T6G 2E1, Canada., Young HS; Department of Biochemistry, University of Alberta, Edmonton, Alberta T6G 2H7, Canada., Lemieux MJ; Department of Biochemistry, University of Alberta, Edmonton, Alberta T6G 2H7, Canada.; Li Ka Shing Institute of Virology, University of Alberta, Edmonton, Alberta T6G 2E1, Canada.

Publikováno v: ACS central science [ACS Cent Sci] 2023 Mar 21; Vol. 9 (4), pp. 696-708. Date of Electronic Publication: 2023 Mar 21 (Print Publication: 2023).

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Akademický článek

Establishing an Integrated Curriculum to Improve Patient Safety and Quality Care.

Autor: Nieman JA; Joyce A. Nieman, MHS, PA-C, MLS(ASCP), is director of clinical education and simulation at the University of California San Diego School of Medicine Richard C. and Rita L. Atkinson Physician Assistant Education Program.; Daniel Boyd Hammond, MPAS, PA-C, is an assistant professor for the Child Health Associate/Physician Assistant Program at the University of Colorado Anschutz Medical Campus in Aurora, Colorado., Hammond DB; Joyce A. Nieman, MHS, PA-C, MLS(ASCP), is director of clinical education and simulation at the University of California San Diego School of Medicine Richard C. and Rita L. Atkinson Physician Assistant Education Program.; Daniel Boyd Hammond, MPAS, PA-C, is an assistant professor for the Child Health Associate/Physician Assistant Program at the University of Colorado Anschutz Medical Campus in Aurora, Colorado.

Publikováno v: The journal of physician assistant education : the official journal of the Physician Assistant Education Association [J Physician Assist Educ] 2023 Mar 01; Vol. 34 (1), pp. 80-82. Date of Electronic Publication: 2023 Jan 11.

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