Permanent Neonatal diabetes-causing Insulin mutations have dominant negative effects on beta cell identity.

Autor: Zhang Y; Naomi Berrie Diabetes Center & Department of Pediatrics, College of Physicians and Surgeons, Columbia University, New York, New York, 10032, United States.; These authors contributed equally., Sui L; Naomi Berrie Diabetes Center & Department of Pediatrics, College of Physicians and Surgeons, Columbia University, New York, New York, 10032, United States.; These authors contributed equally., Du Q; Naomi Berrie Diabetes Center & Department of Pediatrics, College of Physicians and Surgeons, Columbia University, New York, New York, 10032, United States., Haataja L; Metabolism Endocrinology & Diabetes, University of Michigan, Ann Arbor, MI 48105, United States., Yin Y; Naomi Berrie Diabetes Center & Department of Pediatrics, College of Physicians and Surgeons, Columbia University, New York, New York, 10032, United States., Viola R; Naomi Berrie Diabetes Center & Department of Pediatrics, College of Physicians and Surgeons, Columbia University, New York, New York, 10032, United States., Xu S; Naomi Berrie Diabetes Center & Department of Pediatrics, College of Physicians and Surgeons, Columbia University, New York, New York, 10032, United States., Nielsson CU; Naomi Berrie Diabetes Center & Department of Pediatrics, College of Physicians and Surgeons, Columbia University, New York, New York, 10032, United States., Leibel RL; Naomi Berrie Diabetes Center & Department of Pediatrics, College of Physicians and Surgeons, Columbia University, New York, New York, 10032, United States., Barbetti F; Department of Experimental Medicine, University of Rome Tor Vergata, Rome 00133, Italy.; Monogenic Diabetes Clinic, Endocrinology and Diabetes Unit, Bambino Gesù Children's Hospital, Rome 00164, Italy., Arvan P; Metabolism Endocrinology & Diabetes, University of Michigan, Ann Arbor, MI 48105, United States., Egli D; Naomi Berrie Diabetes Center & Department of Pediatrics, College of Physicians and Surgeons, Columbia University, New York, New York, 10032, United States.; Lead Contact.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Sep 15. Date of Electronic Publication: 2023 Sep 15.