Increasing number of long-lived ancestors marks a decade of healthspan extension and healthier metabolomics profiles

Autor: Niels van den Berg, Mar Rodríguez-Girondo, Ingrid K. van Dijk, P. Eline Slagboom, Marian Beekman

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)

Abstract Globally, the lifespan of populations increases but the healthspan is lagging behind. Previous research showed that survival into extreme ages (longevity) clusters in families as illustrated by the increasing lifespan of study participants w

Externí odkaz: https://doaj.org/article/766a9773f5514a0f9bf0ddc49e70d005

Longevity defined as top 10% survivors and beyond is transmitted as a quantitative genetic trait

Autor: Niels van den Berg, Mar Rodríguez-Girondo, Ingrid K. van Dijk, Rick J. Mourits, Kees Mandemakers, Angelique A. P. O. Janssens, Marian Beekman, Ken R. Smith, P. Eline Slagboom

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)

While human lifespan is only moderately heritable, “getting old” runs in families. Here, van den Berg et al. study mortality data from three-generation cohorts to define a threshold for longevity and find that individuals have an increasing survi

Externí odkaz: https://doaj.org/article/44642dfb9cb94830b8332d5e5db86fc0

Effects of residual stresses on fatigue crack propagation of an orthotropic steel bridge deck

Autor: Niels van den Berg, Haohui Xin, Milan Veljkovic

Publikováno v: Materials & Design, Vol 198, Iss , Pp 109294- (2021)

Orthotropic steel decks (OSD's) are susceptible to fatigue failure due to cyclic loading. Often fatigue cracks are found in the joint between the deck plate and the trough. Due to the welding process, residual stresses are present in and around the j

Externí odkaz: https://doaj.org/article/16a0fe0426f849e6b8336d55ad219d4e

Improved selection of participants in genetic longevity studies: family scores revisited

Autor: Eline Slagboom, Mar Rodríguez-Girondo, Michel H. Hof, Marian Beekman, Niels van den Berg

Publikováno v: BMC medical research methodology, 21(1):7. BioMed Central
BMC Medical Research Methodology
BMC MEDICAL RESEARCH METHODOLOGY
BMC Medical Research Methodology, 21(1). BMC
BMC Medical Research Methodology, Vol 21, Iss 1, Pp 1-11 (2021)

Background Although human longevity tends to cluster within families, genetic studies on longevity have had limited success in identifying longevity loci. One of the main causes of this limited success is the selection of participants. Studies genera

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7436500f25079d38ef60abbb9e2c5711
https://pure.amc.nl/en/publications/improved-selection-of-participants-in-genetic-longevity-studies-family-scores-revisited(1e70531e-b3ed-460a-8c01-ea2de7ed7494).html

Family matters in unraveling human longevity

Autor: Niels van den Berg

Publikováno v: Aging (Albany NY)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae18366d60e9056a4255f8eb60f474a8
https://doi.org/10.18632/aging.104218