Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Niels Wellner"'
Autor:
Giulia Monti, Mads Kjolby, Anne Mette G. Jensen, Mariet Allen, Juliane Reiche, Peter L. Møller, Raquel Comaposada-Baró, Bartlomiej E. Zolkowski, Cármen Vieira, Margarita Melnikova Jørgensen, Ida E. Holm, Paul N. Valdmanis, Niels Wellner, Christian B. Vægter, Sarah J. Lincoln, Anders Nykjær, Nilüfer Ertekin-Taner, Jessica E. Young, Mette Nyegaard, Olav M. Andersen
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-18 (2021)
Abstract SORL1 is strongly associated with both sporadic and familial forms of Alzheimer’s disease (AD), but a lack of information about alternatively spliced transcripts currently limits our understanding of the role of SORL1 in AD. Here, we descr
Externí odkaz:
https://doaj.org/article/6593f8c6612a4dd48b7424bbb99fda5f
Autor:
Ditte Olsen, Niels Wellner, Mathias Kaas, Inge E. M. de Jong, Florence Sotty, Michael Didriksen, Simon Glerup, Anders Nykjaer
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Attention deficit hyperactivity disorder (ADHD) is the most frequently diagnosed neurodevelopmental disorder worldwide. Affected individuals present with hyperactivity, inattention, and cognitive deficits and display a characteristic paradox
Externí odkaz:
https://doaj.org/article/92593cd7cc714224b571f4954375bcbe
Autor:
Camilla Gustafsen, Ditte Olsen, Joachim Vilstrup, Signe Lund, Anika Reinhardt, Niels Wellner, Torben Larsen, Christian B. F. Andersen, Kathrin Weyer, Jin-ping Li, Peter H. Seeberger, Søren Thirup, Peder Madsen, Simon Glerup
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
PCSK9 interacts with LDL receptor, causing its degradation, and consequently reduces the clearance of LDL. Here, Gustafsen et al. show that PCSK9 interacts with heparan sulfate proteoglycans and this binding favors LDLR degradation. Pharmacological i
Externí odkaz:
https://doaj.org/article/e6df4a8d335842ca8793c25354c164bc
Autor:
Marcus Daniel Brandbjerg Bohn Lorensen, Sidra Yasmine Hayat, Niels Wellner, Nanna Bjarnholt, Christian Janfelt
Publikováno v:
Lorensen, M D B B, Hayat, S Y, Wellner, N, Bjarnholt, N & Janfelt, C 2023, ' Leaves of Cannabis sativa and their trichomes studied by DESI and MALDI mass spectrometry imaging for their contents of cannabinoids and flavonoids ', Phytochemical Analysis, vol. 34, no. 3, pp. 269-279 . https://doi.org/10.1002/pca.3202
Introduction: In recent years, industrial production of Cannabis sativa has increased due to increased demand of medicinal products based on the plant. In these medicinal products, it is mainly the contents of cannabinoids like THCA and CBDA which ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::723d6825f5f76e72bc7a7f050525694b
https://doi.org/10.1002/pca.3202
https://doi.org/10.1002/pca.3202
Autor:
Sarah Lincoln, Peter L. Møller, Juliane Reiche, Anne Mette G. Jensen, Margarita Melnikova Jørgensen, Bartlomiej E. Zolkowski, Niels Wellner, Mads Kjolby, Anders Nykjaer, Jessica E. Young, Ida E. Holm, Nilufer Ertekin-Taner, Giulia Monti, Mariet Allen, Christian Bjerggaard Vaegter, Olav M. Andersen, Raquel Comaposada-Baró, Paul N. Valdmanis, Cármen Vieira, Mette Nyegaard
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-18 (2021)
Acta Neuropathologica Communications
Monti, G, Kjolby, M, Jensen, A M G, Allen, M, Reiche, J, Møller, P L, Comaposada-Baró, R, Zolkowski, B E, Vieira, C, Jørgensen, M M, Holm, I E, Valdmanis, P N, Wellner, N, Vægter, C B, Lincoln, S J, Nykjær, A, Ertekin-Taner, N, Young, J E, Nyegaard, M & Andersen, O M 2021, ' Expression of an alternatively spliced variant of SORL1 in neuronal dendrites is decreased in patients with Alzheimer's disease ', Acta Neuropathologica Communications, vol. 9, 43 . https://doi.org/10.1186/s40478-021-01140-7
Acta Neuropathologica Communications
Monti, G, Kjolby, M, Jensen, A M G, Allen, M, Reiche, J, Møller, P L, Comaposada-Baró, R, Zolkowski, B E, Vieira, C, Jørgensen, M M, Holm, I E, Valdmanis, P N, Wellner, N, Vægter, C B, Lincoln, S J, Nykjær, A, Ertekin-Taner, N, Young, J E, Nyegaard, M & Andersen, O M 2021, ' Expression of an alternatively spliced variant of SORL1 in neuronal dendrites is decreased in patients with Alzheimer's disease ', Acta Neuropathologica Communications, vol. 9, 43 . https://doi.org/10.1186/s40478-021-01140-7
SORL1 is strongly associated with both sporadic and familial forms of Alzheimer’s disease (AD), but a lack of information about alternatively spliced transcripts currently limits our understanding of the role of SORL1 in AD. Here, we describe a SOR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79ad653f92bf542e720982592384a034
https://doaj.org/article/6593f8c6612a4dd48b7424bbb99fda5f
https://doaj.org/article/6593f8c6612a4dd48b7424bbb99fda5f
Autor:
Mads Kjolby, Peter Breining, Karen Pedersen, Niels Wellner, Karen Sørensen, Anette Gjessing, Dovile Januliene, Dorthe Vittrup, Arulmani Manavalan, Maarten Rotman, Gangadaar Thotakura, Guido Hermey, Peder Madsen, Christian Vaegter, Søren Thirup, Olof Asplund, Rashmi Prasad, Edwin Parlevliet, Patrick Rensen, Andreas Madsen, Birgitte Holst, Olav Andersen, Arne Moller, Torben Hansen, Anders Nykjaer
Type 2 diabetes has reached endemic proportions and is a substantial burden for the affected patients and the society. Along with lifestyle factors, a number of genetic loci predisposing to type 2 diabetes have been identified, including SORCS1 that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec672209d92bb95a06749b31dbc88c6e
https://doi.org/10.21203/rs.3.rs-1299440/v1
https://doi.org/10.21203/rs.3.rs-1299440/v1
Autor:
Rashmi B. Prasad, Torben Hansen, Patrick C.N. Rensen, Sune Skeldal, Dorthe Maria Vittrup, Karen M. Pedersen, Olof Asplund, Christian Bjerggaard Vaegter, Anette Marianne Prior Gjessing, Andreas N. Madsen, Karen Marie Juul Sørensen, Mads Kjolby, Maarten Rotman, Dovile Januliene, Olav M. Andersen, Guido Hermey, Edwin T. Parlevliet, Birgitte Holst, Arne Moller, Gangadaar Thotakura, Ernst-Martin Füchtbauer, Søren Thirup, Peder Madsen, Niels Wellner, Peter Breining, Arulmani Manavalan
Type II diabetes mellitus (T2DM) has reached endemic levels and comprises a substantial burden to the patient and the society. Along with lifestyle factors, a number of genetic loci predisposing to T2DM have been suggested including SORCS1 that encod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cbdadf328d061149c37f06c00ea13f49
https://doi.org/10.1101/2020.11.10.376178
https://doi.org/10.1101/2020.11.10.376178
Autor:
Christian Brix Folsted Andersen, Jin-Ping Li, Joachim Vilstrup, Simon Glerup, Camilla Gustafsen, Peder Madsen, Søren Thirup, Anika Reinhardt, Kathrin Weyer, Torben Larsen, Niels Wellner, Signe Lund, Peter H. Seeberger, Ditte Olsen
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Gustafsen, C, Olsen, D, Vilstrup, J, Lund, S, Reinhardt, A, Wellner, N, Larsen, T, Andersen, C B F, Weyer, K, Li, J-P, Seeberger, P H, Thirup, S, Madsen, P & Glerup, S 2017, ' Heparan sulfate proteoglycans present PCSK9 to the LDL receptor ', Nature Communications, vol. 8, no. 1, pp. 503 . https://doi.org/10.1038/s41467-017-00568-7
Nature Communications
Gustafsen, C, Olsen, D, Vilstrup, J, Lund, S, Reinhardt, A, Wellner, N, Larsen, T, Andersen, C B F, Weyer, K, Li, J-P, Seeberger, P H, Thirup, S, Madsen, P & Glerup, S 2017, ' Heparan sulfate proteoglycans present PCSK9 to the LDL receptor ', Nature Communications, vol. 8, no. 1, pp. 503 . https://doi.org/10.1038/s41467-017-00568-7
Nature Communications
Coronary artery disease is the main cause of death worldwide and accelerated by increased plasma levels of cholesterol-rich low-density lipoprotein particles (LDL). Circulating PCSK9 contributes to coronary artery disease by inducing lysosomal degrad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54b9c9a06332998a9d20f0f662317a56
http://link.springer.com/article/10.1038/s41467-017-00568-7
http://link.springer.com/article/10.1038/s41467-017-00568-7
Autor:
Suneel S. Apte, Birgitte Holst, Marie Balslev Backe, Jesper B. Birk, Annette K. Serup, Steen Larsen, Linn Gillberg, Björn Zethelius, Niels Wellner, Karolina Sulek, Jonas T. Treebak, Allan Vaag, Sara H Lystbæk, Anders Nykjaer, Hans-Ulrich Häring, Rasmus Ribel-Madsen, Trine Welløv Boesgaard, Jørgen F. P. Wojtaszewski, Niels Grarup, Johanne Dubail, Sabina Chubanava, Mads Kjolby, Harald Staiger, Clara Prats, Anne-Sofie Graae, Andreas Fritsche, Sara G. Vienberg, Torben Hansen, Bente Kiens, Oluf Pedersen
Publikováno v:
Diabetes 68, 502-514 (2019)
Graae, A-S, Grarup, N, Ribel-Madsen, R, Lystbæk, S H, Boesgaard, T, Staiger, H, Fritsche, A, Wellner, N, Sulek, K, Kjolby, M, Backe, M B, Chubanava, S, Prats, C, Serup, A K, Birk, J B, Dubail, J, Gillberg, L, Vienberg, S G, Nykjær, A, Kiens, B, Wojtaszewski, J F P, Larsen, S, Apte, S S, Häring, H-U, Vaag, A, Zethelius, B, Pedersen, O, Treebak, J T, Hansen, T & Holst, B 2019, ' ADAMTS9 regulates skeletal muscle insulin sensitivity through extracellular matrix alterations ', Diabetes, vol. 68, no. 3, pp. 502-514 . https://doi.org/10.2337/db18-0418
Diabetes
Graae, A S, Grarup, N, Ribel-Madsen, R, Lystbæk, S H, Boesgaard, T, Staiger, H, Fritsche, A, Wellner, N, Sulek, K, Kjolby, M, Backe, M B, Chubanava, S, Prats, C, Serup, A K, Birk, J B, Dubail, J, Gillberg, L, Vienberg, S G, Nykjær, A, Kiens, B, Wojtaszewski, J F P, Larsen, S, Apte, S S, Häring, H U, Vaag, A, Zethelius, B, Pedersen, O, Treebak, J T, Hansen, T & Holst, B 2019, ' ADAMTS9 regulates skeletal muscle insulin sensitivity through extracellular matrix alterations ' Diabetes, vol. 68, no. 3, pp. 502-514 . https://doi.org/10.2337/db18-0418
Graae, A-S, Grarup, N, Ribel-Madsen, R, Lystbæk, S H, Boesgaard, T, Staiger, H, Fritsche, A, Wellner, N, Sulek, K, Kjolby, M, Backe, M B, Chubanava, S, Prats, C, Serup, A K, Birk, J B, Dubail, J, Gillberg, L, Vienberg, S G, Nykjær, A, Kiens, B, Wojtaszewski, J F P, Larsen, S, Apte, S S, Häring, H-U, Vaag, A, Zethelius, B, Pedersen, O, Treebak, J T, Hansen, T & Holst, B 2019, ' ADAMTS9 regulates skeletal muscle insulin sensitivity through extracellular matrix alterations ', Diabetes, vol. 68, no. 3, pp. 502-514 . https://doi.org/10.2337/db18-0418
Diabetes
Graae, A S, Grarup, N, Ribel-Madsen, R, Lystbæk, S H, Boesgaard, T, Staiger, H, Fritsche, A, Wellner, N, Sulek, K, Kjolby, M, Backe, M B, Chubanava, S, Prats, C, Serup, A K, Birk, J B, Dubail, J, Gillberg, L, Vienberg, S G, Nykjær, A, Kiens, B, Wojtaszewski, J F P, Larsen, S, Apte, S S, Häring, H U, Vaag, A, Zethelius, B, Pedersen, O, Treebak, J T, Hansen, T & Holst, B 2019, ' ADAMTS9 regulates skeletal muscle insulin sensitivity through extracellular matrix alterations ' Diabetes, vol. 68, no. 3, pp. 502-514 . https://doi.org/10.2337/db18-0418
The ADAMTS9 rs4607103 C allele is one of the few gene variants proposed to increase the risk of type 2 diabetes through an impairment of insulin sensitivity. We show that the variant is associated with increased expression of the secreted ADAMTS9 and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce1222d05d40196cc2a07501a33f4eb3
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=55586
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=55586
Autor:
Sarah Lincoln, Mads Fuglsang Kjølby, Giulia Monti, Juliane Reiche, Mette Nyegaard, Margarita Melnikova, Olav M. Andersen, Christian Bjerggaard Vaegter, Mariet Allen, Anders Nykjaer, Niels Wellner, Raquel Comaposada Barò, Ida E. Holm, Nilufer Ertekin-Taner
Publikováno v:
Alzheimer's & Dementia. 14
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::773f3fb14d5ab8065c2e65c39d125fc2
https://doi.org/10.1016/j.jalz.2018.07.081
https://doi.org/10.1016/j.jalz.2018.07.081