Genome-wide study investigating effector genes and polygenic prediction for kidney function in persons with ancestry from Africa and the Americas

Autor: Odessica Hughes, Amy R. Bentley, Charles E. Breeze, Francois Aguet, Xiaoguang Xu, Girish Nadkarni, Quan Sun, Bridget M. Lin, Thomas Gilliland, Mariah C. Meyer, Jiawen Du, Laura M. Raffield, Holly Kramer, Robert W. Morton, Mateus H. Gouveia, Elizabeth G. Atkinson, Adan Valladares-Salgado, Niels Wacher-Rodarte, Nicole D. Dueker, Xiuqing Guo, Yang Hai, Adebowale Adeyemo, Lyle G. Best, Jianwen Cai, Guanjie Chen, Michael Chong, Ayo Doumatey, James Eales, Mark O. Goodarzi, Eli Ipp, Marguerite Ryan Irvin, Minzhi Jiang, Alana C. Jones, Charles Kooperberg, Jose E. Krieger, Ethan M. Lange, Matthew B. Lanktree, James P. Lash, Paulo A. Lotufo, Ruth J.F. Loos, Vy Thi Ha My, Jesús Peralta-Romero, Lihong Qi, Leslie J. Raffel, Stephen S. Rich, Erik J. Rodriquez, Eduardo Tarazona-Santos, Kent D. Taylor, Jason G. Umans, Jia Wen, Bessie A. Young, Zhi Yu, Ying Zhang, Yii-Der Ida Chen, Tanja Rundek, Jerome I. Rotter, Miguel Cruz, Myriam Fornage, Maria Fernanda Lima-Costa, Alexandre C. Pereira, Guillaume Paré, Pradeep Natarajan, Shelley A. Cole, April P. Carson, Leslie A. Lange, Yun Li, Eliseo J. Perez-Stable, Ron Do, Fadi J. Charchar, Maciej Tomaszewski, Josyf C. Mychaleckyj, Charles Rotimi, Andrew P. Morris, Nora Franceschini

Publikováno v: Cell Genomics, Vol 4, Iss 1, Pp 100468- (2024)

Summary: Chronic kidney disease is a leading cause of death and disability globally and impacts individuals of African ancestry (AFR) or with ancestry in the Americas (AMS) who are under-represented in genome-wide association studies (GWASs) of kidne

Externí odkaz: https://doaj.org/article/975974e930614de28f7b1b95b70b9859

Increased expression of hypoxia-induced factor 1α mRNA and its related genes in myeloid blood cells from critically ill COVID-19 patients

Autor: Keiko Taniguchi-Ponciano, Eduardo Vadillo, Héctor Mayani, César Raúl Gonzalez-Bonilla, Javier Torres, Abraham Majluf, Guillermo Flores-Padilla, Niels Wacher-Rodarte, Juan Carlos Galan, Eduardo Ferat-Osorio, Francisco Blanco-Favela, Constantino Lopez-Macias, Aldo Ferreira-Hermosillo, Claudia Ramirez-Renteria, Eduardo Peña-Martínez, Gloria Silva-Román, Sandra Vela-Patiño, Carlos Mata-Lozano, Roberto Carvente-Garcia, Lourdes Basurto-Acevedo, Renata Saucedo, Patricia Piña-Sanchez, Antonieta Chavez-Gonzalez, Daniel Marrero-Rodríguez, Moisés Mercado

Publikováno v: Annals of Medicine, Vol 53, Iss 1, Pp 197-207 (2021)

AbstractBackground COVID-19 counts 46 million people infected and killed more than 1.2 million. Hypoxaemia is one of the main clinical manifestations, especially in severe cases. HIF1α is a master transcription factor involved in the cellular respon

Externí odkaz: https://doaj.org/article/d7d5cbc7ec954c4fbfb9590414a7248c

Post-cardioversion time Course of Atrial Remodeling Markers and their Association with Recurrence in Subjects with Long-standing, Persistent Atrial Fibrillation

Autor: Luis Antonio Moreno-Ruiz, Luis Chávez-Sánchez, Wendy Vazquez-González, Alejandra Madrid-Miller, Noe Zamorano-Velázquez, Enrique Martinez-Flores, Niels Wacher-Rodarte, Antonio González-Hermosillo, Francisco Blanco-Favela

Publikováno v: Archives of medical research. 53(7)

Activation of the renin-angiotensin-aldosterone axis with elevation of inflammatory markers and the resulting fibrosis play a very important role in atrial remodeling in patients with atrial fibrillation (AF), which is associated with post-cardiovers

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::848dcd664757f2d27a20ebd6aec47269
https://pubmed.ncbi.nlm.nih.gov/36244846

Evaluation of predictive value of olfactory dysfunction, as a screening tool for COVID‐19

Autor: Salomón Waizel-Haiat, Tania Colin-Martínez, José Luis Martínez-Ordaz, Guadalupe Vargas-Ortega, Alfredo Anaya‐Dyck, Baldomero González-Virla, Eduardo Ferat-Osorio, Mayra Alejandra López-Moreno, Niels Wacher Rodarte, Carlos Alfonso Romero-Gameros, Eulalio Vivar-Acevedo, Victoria Mendoza-Zubieta

Publikováno v: Laryngoscope Investigative Otolaryngology

Objectives At the end of 2019, SARS‐CoV‐2 was identified, the one responsible for the COVID‐19 disease. Between a 5.1% and a 98% of COVID‐19 patients present some form of alteration in their sense of smell. The objective of this study is to d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b576a065c2c08c56ce4045da23b0c91
http://europepmc.org/articles/PMC7752039

The Melanocortin 4 Receptor p.Ile269Asn Mutation Is Associated with Childhood and Adult Obesity in Mexicans

Autor: Miguel Cruz, David Meyre, Jesús Peralta-Romero, Hamza Asif, Miguel Vázquez-Moreno, Niels Wacher-Rodarte, Gloria Patricia Sosa-Bustamante, Vivian W.Y. Tam, Helen Zeng, Daniel Locia-Morales, Arjuna Maharaj, Socorro Méndez-Martínez, María del Socorro Romero-Figueroa, Adan Valladares-Salgado, Aurora Mejía-Benítez

Publikováno v: The Journal of Clinical Endocrinology & Metabolism. 105:e1468-e1477

Context Rare partial/complete loss-of-function mutations in the melanocortin-4 receptor (MC4R) gene are the most common cause of Mendelian obesity in European populations, but their contribution to obesity in the Mexican population is unclear. Object

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d27be44a9fcdf02c860e1501dee090fd
https://doi.org/10.1210/clinem/dgz276