Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Niels Verburg"'
Autor:
Caterina Brighi, Niels Verburg, Eng-Siew Koh, Amy Walker, Cathy Chen, Sugendran Pillay, Philip C. de Witt Hamer, Farhannah Aly, Lois C. Holloway, Paul J. Keall, David E.J. Waddington
Publikováno v:
Physics and Imaging in Radiation Oncology, Vol 23, Iss , Pp 8-15 (2022)
Background and purpose: Glioblastoma (GBM) patients have a dismal prognosis. Tumours typically recur within months of surgical resection and post-operative chemoradiation. Multiparametric magnetic resonance imaging (mpMRI) biomarkers promise to impro
Externí odkaz:
https://doaj.org/article/ccc04573c6b34bc88475161dde74b6eb
Autor:
Niels Verburg, Thomas Koopman, Maqsood Yaqub, Otto S. Hoekstra, Adriaan A. Lammertsma, Lothar A. Schwarte, Frederik Barkhof, Petra J. W. Pouwels, Jan J. Heimans, Jaap C. Reijneveld, Annemieke J. M. Rozemuller, William P. Vandertop, Pieter Wesseling, Ronald Boellaard, Philip C. de Witt Hamer
Publikováno v:
EJNMMI Research, Vol 9, Iss 1, Pp 1-9 (2019)
Abstract Background Positron emission tomography (PET) is increasingly used to guide local treatment in glioma. The purpose of this study was a direct comparison of two potential tracers for detecting glioma infiltration, O-(2-[18F]-fluoroethyl)-l-ty
Externí odkaz:
https://doaj.org/article/6d9c6a5bb9024f70a10e92b69f8c0b8e
Autor:
Thomas Koopman, Niels Verburg, Robert C. Schuit, Petra J. W. Pouwels, Pieter Wesseling, Albert D. Windhorst, Otto S. Hoekstra, Philip C. de Witt Hamer, Adriaan A. Lammertsma, Ronald Boellaard, Maqsood Yaqub
Publikováno v:
EJNMMI Research, Vol 8, Iss 1, Pp 1-9 (2018)
Abstract Background This study identified the optimal tracer kinetic model for quantification of dynamic O-(2-[18F]fluoroethyl)-L-tyrosine ([18F]FET) positron emission tomography (PET) studies in seven patients with diffuse glioma (four glioblastoma,
Externí odkaz:
https://doaj.org/article/50f1ee5529d3411bac7070c186c4c5c8
Autor:
Zhiqing Zhang, Jan C. de Munck, Niels Verburg, Annemieke J. Rozemuller, Willem Vreuls, Pinar Cakmak, Laura M. G. van Huizen, Sander Idema, Eleonora Aronica, Philip C. de Witt Hamer, Pieter Wesseling, Marie Louise Groot
Publikováno v:
Advanced Science, Vol 6, Iss 11, Pp n/a-n/a (2019)
Abstract Distinguishing tumors from normal brain cells is important but challenging in glioma surgery due to the lack of clear interfaces between the two. The ability of label‐free third harmonic generation (THG) microscopy in combination with auto
Externí odkaz:
https://doaj.org/article/900390b26aa7491e849b470796ed753e
Autor:
René Wilbers, Verjinia D. Metodieva, Sarah Duverdin, Djai B. Heyer, Anna A. Galakhova, Eline J. Mertens, Tamara D. Versluis, Johannes C. Baayen, Sander Idema, David P. Noske, Niels Verburg, Ronald B. Willemse, Philip C. de Witt Hamer, Maarten H. P. Kole, Christiaan P.J. de Kock, Huibert D. Mansvelder, Natalia A. Goriounova
Human cortical pyramidal neurons are large, have extensive dendritic trees, and yet have surprisingly fast input-output properties: rapid subthreshold synaptic membrane potential changes are reliably encoded in timing of action potentials (APs). Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e2879fb92cd26c33bd4d472d55460a29
https://doi.org/10.1101/2022.11.29.518317
https://doi.org/10.1101/2022.11.29.518317
Autor:
Caterina Brighi, Paul J Keall, Lois C Holloway, Amy Walker, Brendan Whelan, Philip C de Witt Hamer, Niels Verburg, Farhannah Aly, Cathy Chen, Eng-Siew Koh, David E J Waddington
Publikováno v:
Neuro-oncology advances, 4(1):vdac134. Oxford University Press
Brighi, C, Keall, P J, Holloway, L C, Walker, A, Whelan, B, de Witt Hamer, P C, Verburg, N, Aly, F, Chen, C, Koh, E-S & Waddington, D E J 2022, ' An investigation of the conformity, feasibility, and expected clinical benefits of multiparametric MRI-guided dose painting radiotherapy in glioblastoma ', Neuro-oncology advances, vol. 4, no. 1, vdac134 . https://doi.org/10.1093/noajnl/vdac134
Brighi, C, Keall, P J, Holloway, L C, Walker, A, Whelan, B, de Witt Hamer, P C, Verburg, N, Aly, F, Chen, C, Koh, E-S & Waddington, D E J 2022, ' An investigation of the conformity, feasibility, and expected clinical benefits of multiparametric MRI-guided dose painting radiotherapy in glioblastoma ', Neuro-oncology advances, vol. 4, no. 1, vdac134 . https://doi.org/10.1093/noajnl/vdac134
Background New technologies developed to improve survival outcomes for glioblastoma (GBM) continue to have limited success. Recently, image-guided dose painting (DP) radiotherapy has emerged as a promising strategy to increase local control rates. In
Autor:
Philip C. De Witt Hamer, Petra J. W. Pouwels, W Pieter Vandertop, Frederik Barkhof, Otto S. Hoekstra, Kevin J. Anderson, Sunit Das, Annemieke J.M. Rozemuller, Niels Verburg, Pieter Wesseling, Ronald Boellaard, Michael D. Taylor, Jeroen A.M. Beliën, Jaap C. Reijneveld, Roel G.W. Verhaak, Maqsood Yaqub, Joseph F. Costello, Kevin C. Johnson, Adriaan A. Lammertsma, Floris P. Barthel, Thomas Koopman
Publikováno v:
Neuro-Oncology, 23(12), 2054-2065. Oxford University Press
Verburg, N, Barthel, F P, Anderson, K J, Johnson, K C, Koopman, T, Yaqub, M M, Hoekstra, O S, Lammertsma, A A, Barkhof, F, Pouwels, P J W, Reijneveld, J C, Rozemuller, A J M, Beliën, J A M, Boellaard, R, Taylor, M D, Das, S, Costello, J F, Vandertop, W P, Wesseling, P, de Witt Hamer, P C & Verhaak, R G W 2021, ' Spatial concordance of DNA methylation classification in diffuse glioma ', Neuro-Oncology, vol. 23, no. 12, pp. 2054-2065 . https://doi.org/10.1093/neuonc/noab134
Neuro-Oncology, vol 23, iss 12
Neuro-oncology, 23(12), 2054-2065. Oxford University Press
Neuro-Oncology
Verburg, N, Barthel, F P, Anderson, K J, Johnson, K C, Koopman, T, Yaqub, M M, Hoekstra, O S, Lammertsma, A A, Barkhof, F, Pouwels, P J W, Reijneveld, J C, Rozemuller, A J M, Beliën, J A M, Boellaard, R, Taylor, M D, Das, S, Costello, J F, Vandertop, W P, Wesseling, P, de Witt Hamer, P C & Verhaak, R G W 2021, ' Spatial concordance of DNA methylation classification in diffuse glioma ', Neuro-Oncology, vol. 23, no. 12, pp. 2054-2065 . https://doi.org/10.1093/neuonc/noab134
Neuro-Oncology, vol 23, iss 12
Neuro-oncology, 23(12), 2054-2065. Oxford University Press
Neuro-Oncology
Background Intratumoral heterogeneity is a hallmark of diffuse gliomas. DNA methylation profiling is an emerging approach in the clinical classification of brain tumors. The goal of this study is to investigate the effects of intratumoral heterogenei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::500075d31fc825394290fd5a81476763
https://research.vumc.nl/en/publications/d65cfd45-3b50-4b9f-91a1-55557b4b5eab
https://research.vumc.nl/en/publications/d65cfd45-3b50-4b9f-91a1-55557b4b5eab
Autor:
Rahul Maurya, Hoon Kim, Sunit Das, Amit D. Gujar, Philip C. De Witt Hamer, Elise T. Courtois, Chew Yee Ngan, Kevin J. Anderson, Floris P. Barthel, Niels Verburg, Kevin C. Johnson, Dacheng Zhao, Ketan R. Bulsara, Martine Seignon, Paul Robson, Frederick S. Varn, Eun Hee Yi, Nicholas Navin, Marcos R. Estecio, Diane Luo, Roel G.W. Verhaak, Michael Samuels, Ming Tang
Publikováno v:
Johnson, K C, Anderson, K J, Courtois, E T, Gujar, A D, Barthel, F P, Varn, F S, Luo, D, Seignon, M, Yi, E, Kim, H, Estecio, M R H, Zhao, D, Tang, M, Navin, N E, Maurya, R, Ngan, C Y, Verburg, N, de Witt Hamer, P C, Bulsara, K, Samuels, M L, Das, S, Robson, P & Verhaak, R G W 2021, ' Single-cell multimodal glioma analyses identify epigenetic regulators of cellular plasticity and environmental stress response ', Nature Genetics, vol. 53, no. 10, pp. 1456-1468 . https://doi.org/10.1038/s41588-021-00926-8
Nature Genetics, 53(10), 1456-1468. Nature Publishing Group
Nature Genetics, 53(10), 1456-1468. Nature Publishing Group
Glioma intratumoral heterogeneity enables adaptation to challenging microenvironments and contributes to therapeutic resistance. We integrated 914 single-cell DNA methylomes, 55,284 single-cell transcriptomes and bulk multi-omic profiles across 11 ad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aad1ae7e79d3ae7c7008a19eba37ea4d
https://research.vumc.nl/en/publications/3ef3cb20-34eb-4d85-9b84-b617090e15d1
https://research.vumc.nl/en/publications/3ef3cb20-34eb-4d85-9b84-b617090e15d1
Autor:
Petra J. W. Pouwels, Philip C. De Witt Hamer, Ronald Boellaard, Niels Verburg, Pieter Wesseling, Maqsood Yaqub, Thomas Koopman, Otto S. Hoekstra, Adriaan A. Lammertsma
Publikováno v:
Journal of Cerebral Blood Flow and Metabolism, 40(4), 895-903. SAGE Publications Inc.
Journal of Cerebral Blood Flow and Metabolism, 40(4), 895-903. Nature Publishing Group
Koopman, T, Verburg, N, Pouwels, P J W, Wesseling, P, Hoekstra, O S, De Witt Hamer, P C, Lammertsma, A A, Yaqub, M & Boellaard, R 2020, ' Quantitative parametric maps of O-(2-[ 18 F]fluoroethyl)-L-tyrosine kinetics in diffuse glioma ', Journal of Cerebral Blood Flow and Metabolism, vol. 40, no. 4, pp. 895-903 . https://doi.org/10.1177/0271678X19851878
Journal of Cerebral Blood Flow and Metabolism, 40(4), 895-903. Nature Publishing Group
Koopman, T, Verburg, N, Pouwels, P J W, Wesseling, P, Hoekstra, O S, De Witt Hamer, P C, Lammertsma, A A, Yaqub, M & Boellaard, R 2020, ' Quantitative parametric maps of O-(2-[ 18 F]fluoroethyl)-L-tyrosine kinetics in diffuse glioma ', Journal of Cerebral Blood Flow and Metabolism, vol. 40, no. 4, pp. 895-903 . https://doi.org/10.1177/0271678X19851878
Quantitative parametric images of O-(2-[18F]fluoroethyl)-L-tyrosine kinetics in diffuse gliomas could be used to improve glioma grading, tumour delineation or the assessment of the uptake distribution of this positron emission tomography tracer. In t
Autor:
Frederick S. Varn, Ming Tang, Hoon Kim, Floris P. Barthel, Paul Robson, Michael L. Samuels, Elise T. Courtois, Nicholas Navin, Kevin C. Johnson, Philip C. De Witt Hamer, Kevin J. Anderson, Niels Verburg, Amit D. Gujar, Marcos R. Estecio, Diane Luo, Ketan R. Bulsara, Roel G.W. Verhaak, Eun Hee Yi, Martine Seignon, Rahul Maurya, Chew Yee Ngan, Sunit Das
Publikováno v:
Cancer Research. 81:2084-2084
Glioma intratumoral heterogeneity enables adaptation to challenging microenvironments and contributes to universal therapeutic resistance. Here, we integrated 914 single-cell DNA methylomes, 55,284 single-cell transcriptomes, and bulk multi-omic prof