Effect of the KCa3.1 blocker, senicapoc, on cerebral edema and cardiovascular function after cardiac arrest — A randomized experimental rat study

Autor: Frederik Boe Hansen, Niels Secher, Thomas Mattson, Bo Løfgren, Ulf Simonsen, Asger Granfeldt

Publikováno v: Resuscitation Plus, Vol 6, Iss , Pp 100111- (2021)

Aim: Formation of cerebral edema and cardiovascular dysfunction may worsen brain injury following cardiac arrest. We hypothesized that administration of the intermediate calcium-activated potassium (KCa3.1) channel blocker, senicapoc, would reduce ce

Externí odkaz: https://doaj.org/article/30c4973e5aab40c6934d17b75ef905a7

α-Melanocyte stimulating hormone treatment in pigs does not improve early graft function in kidney transplants from brain dead donors.

Autor: Willem G van Rijt, Niels Secher, Anna K Keller, Ulla Møldrup, Yahor Chynau, Rutger J Ploeg, Harry van Goor, Rikke Nørregaard, Henrik Birn, Jørgen Frøkiaer, Søren Nielsen, Henri G D Leuvenink, Bente Jespersen

Publikováno v: PLoS ONE, Vol 9, Iss 4, p e94609 (2014)

Delayed graft function and primary non-function are serious complications following transplantation of kidneys derived from deceased brain dead (DBD) donors. α-melanocyte stimulating hormone (α-MSH) is a pleiotropic neuropeptide and its renoprotect

Externí odkaz: https://doaj.org/article/a842997d9d2243dcba89a50536a5c5ee

Integrative omics reveals subtle molecular perturbations following ischemic conditioning in a porcine kidney transplant model

Autor: Darragh P. O’Brien, Adam M. Thorne, Honglei Huang, Elisa Pappalardo, Xuan Yao, Peter Søndergaard Thyrrestrup, Kristian Ravlo, Niels Secher, Rikke Norregaard, Rutger J. Ploeg, Bente Jespersen, Benedikt M. Kessler

Publikováno v: O'Brien, D P, Thorne, A M, Huang, H, Pappalardo, E, Yao, X, Thyrrestrup, P S, Ravlo, K, Secher, N, Norregaard, R, Ploeg, R J, Jespersen, B & Kessler, B M 2022, ' Integrative omics reveals subtle molecular perturbations following ischemic conditioning in a porcine kidney transplant model ', Clinical proteomics, vol. 19, no. 1, 6 . https://doi.org/10.1186/s12014-022-09343-3
O’Brien, D P, Thorne, A M, Huang, H, Pappalardo, E, Yao, X, Thyrrestrup, P S, Ravlo, K, Secher, N, Norregaard, R, Ploeg, R J, Jespersen, B & Kessler, B M 2022, ' Integrative omics reveals subtle molecular perturbations following ischemic conditioning in a porcine kidney transplant model ', Clinical Proteomics, vol. 19, 6 . https://doi.org/10.1186/s12014-022-09343-3

Background Remote Ischemic Conditioning (RIC) has been proposed as a therapeutic intervention to circumvent the ischemia/reperfusion injury (IRI) that is inherent to organ transplantation. Using a porcine kidney transplant model, we aimed to decipher

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80ecb1f5ff3a9dc87f8842689ff6c76f
https://pubmed.ncbi.nlm.nih.gov/35164671

Hydration and the human brain circulation and metabolism

Autor: Steven, Trangmar, Scott, Chiesa, Kameljit, Kalsi, Niels, Secher, José, González-Alonso

Publikováno v: Nutricion hospitalaria. 32

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1fad981294d02385a951438845ce6b87
https://pubmed.ncbi.nlm.nih.gov/26615231

Abstract 18408: Cortical Spreading Depolarizations After Cardiac Arrest in an Asphyxial Rat Model

Autor: Frederik B Hansen, Niels Secher, Leif Østergaard, Morten Skovgaard, Else Tønnesen, Asger Granfeldt

Publikováno v: Circulation. 132

Introduction: Delayed neuronal cell death is observed following cardiac arrest (CA). The exact mechanisms remain unknown. Cortical spreading depolarization (CSD) is characterized by depolarization of neurons and glia cells, spreading as a wave that t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a6493b6e87d2cd65c1f238d3de6aaf0e
https://doi.org/10.1161/circ.132.suppl_3.18408