Zobrazeno 1 - 10
of 270
pro vyhledávání: '"Niels P Riksen"'
Autor:
Roy P C Kessels, Audrey Low, Hugh Markus, Anil Tuladhar, Frank‐Erik de Leeuw, Robin G Morris, Ziad Mallat, Niels P Riksen, Daniel J Tozer, Sanne van Winden, Lupei Cai, Marnix C Maas, Meritxell Nus, Anja van der Kolk, Rowan Wolters
Publikováno v:
BMJ Open, Vol 14, Iss 2 (2024)
Introduction The INflammation and Small Vessel Disease (INSVD) study aims to investigate whether peripheral inflammation, immune (dys)regulation and blood–brain barrier (BBB) permeability relate to disease progression in cerebral small vessel disea
Externí odkaz:
https://doaj.org/article/9de6a34a9f7443a3934e4e2d8c33f96d
Autor:
Peter Pickkers, Mark Rijpkema, Hendrik-Jan Dieker, Julia van Tuijl, Annemieke M Peters van Ton, Harmke B. Duindam, Wilson WL Li, Niels P Riksen, FJ Anton Meijer, Roy PC Kessels, Nils Kohn, Johannes G. van der Hoeven, Wilson F Abdo
Publikováno v:
BMJ Open, Vol 11, Iss 5 (2021)
Introduction Postoperative cognitive dysfunction occurs frequently after coronary artery bypass grafting (CABG). The underlying mechanisms remain poorly understood, but neuroinflammation might play a pivotal role. We hypothesise that systemic inflamm
Externí odkaz:
https://doaj.org/article/ce178f1be39b4bc8b1268dba404ac770
Autor:
Amit Frishberg, Inge van den Munckhof, Rob ter Horst, Kiki Schraa, Leo AB Joosten, Joost HW Rutten, Adrian C Iancu, Ioana M Dregoesc, Bogdan A Tigu, Mihai G Netea, Niels P Riksen, Irit Gat-Viks
Publikováno v:
eLife, Vol 10 (2021)
Human diseases arise in a complex ecosystem composed of disease mechanisms and the whole-body state. However, the precise nature of the whole-body state and its relations with disease remain obscure. Here we map similarities among clinical parameters
Externí odkaz:
https://doaj.org/article/e056a59b1d5b495b9470fb0728d5c3f5
Autor:
Marlies P Noz, Siroon Bekkering, Laszlo Groh, Tim MJ Nielen, Evert JP Lamfers, Andreas Schlitzer, Saloua El Messaoudi, Niels van Royen, Erik HJPG Huys, Frank WMB Preijers, Esther MM Smeets, Erik HJG Aarntzen, Bowen Zhang, Yang Li, Manita EJ Bremmers, Walter JFM van der Velden, Harry Dolstra, Leo AB Joosten, Marc E Gomes, Mihai G Netea, Niels P Riksen
Publikováno v:
eLife, Vol 9 (2020)
Atherosclerosis is the major cause of cardiovascular disease (CVD). Monocyte-derived macrophages are the most abundant immune cells in atherosclerotic plaques. In patients with atherosclerotic CVD, leukocytes have a hyperinflammatory phenotype. We hy
Externí odkaz:
https://doaj.org/article/b39e72c767544715bfa9f5d794429461
Autor:
Raquel Tarancón, Jorge Domínguez-Andrés, Santiago Uranga, Anaísa V Ferreira, Laszlo A Groh, Mirian Domenech, Fernando González-Camacho, Niels P Riksen, Nacho Aguilo, José Yuste, Carlos Martín, Mihai G Netea
Publikováno v:
PLoS Pathogens, Vol 16, Iss 4, p e1008404 (2020)
Among infectious diseases, tuberculosis is the leading cause of death worldwide, and represents a serious threat, especially in developing countries. The protective effects of Bacillus Calmette-Guerin (BCG), the current vaccine against tuberculosis,
Externí odkaz:
https://doaj.org/article/7b71c8787cd644c99f20ce73d47db510
Autor:
Nienke A Hesen, Niels P Riksen, Bart Aalders, Michelle A E Brouwer, Merel Ritskes-Hoitinga, Saloua El Messaoudi, Kimberley E Wever
Publikováno v:
PLoS ONE, Vol 13, Iss 4, p e0195858 (2018)
[This corrects the article DOI: 10.1371/journal.pone.0183664.].
Externí odkaz:
https://doaj.org/article/76cfa438b8b547a8a796501a69821715
Autor:
Nienke A Hesen, Niels P Riksen, Bart Aalders, Michelle AE Brouwer, Merel Ritskes-Hoitinga, Saloua El Messaoudi, Kimberley E Wever
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0183664 (2017)
Metformin improves cardiovascular prognosis in patients with diabetes mellitus, compared to alternative glucose-lowering drugs, despite similar glycemic control. Direct cardiovascular protective properties have therefore been proposed, and studied in
Externí odkaz:
https://doaj.org/article/d818ad21e724471396c52d511761ad04
Autor:
Kimberley E Wever, Carlijn R Hooijmans, Niels P Riksen, Thomas B Sterenborg, Emily S Sena, Merel Ritskes-Hoitinga, Michiel C Warlé
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0142021 (2015)
Ischemic preconditioning (IPC) of the heart is a protective strategy in which a brief ischemic stimulus immediately before a lethal ischemic episode potently limits infarct size. Although very promising in animal models of myocardial infarction, IPC
Externí odkaz:
https://doaj.org/article/97fa9da40d6741f98944589fbcb14588
Autor:
Saloua El Messaoudi, Tim H Schreuder, Roel D Kengen, Gerard A Rongen, Petra H van den Broek, Dick H J Thijssen, Niels P Riksen
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e96062 (2014)
Large prospective studies in patients with type 2 diabetes mellitus have demonstrated that metformin treatment improves cardiovascular prognosis, independent of glycemic control. Administration of metformin potently limits infarct size in murine mode
Externí odkaz:
https://doaj.org/article/b40207f1f7f24896866b70a42a310d85
Autor:
T N A van den Berg, Jaap Deinum, Albert Bilos, A Rogier T Donders, Gerard A Rongen, Niels P Riksen
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e111248 (2014)
It has been suggested that mineralocorticoid receptor antagonists have direct cardioprotective properties, because these drugs reduce mortality in patients with heart failure. In murine models of myocardial infarction, mineralocorticoid receptor anta
Externí odkaz:
https://doaj.org/article/757cbe05964348a9a1bd92491a0cd489