Zobrazeno 1 - 10
of 93
pro vyhledávání: '"Niels Mailand"'
Autor:
Ann Schirin Mirsanaye, Saskia Hoffmann, Melanie Weisser, Andreas Mund, Blanca Lopez Mendez, Dimitris Typas, Johannes van den Boom, Bente Benedict, Ivo A. Hendriks, Michael Lund Nielsen, Hemmo Meyer, Julien P. Duxin, Guillermo Montoya, Niels Mailand
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract The hexameric AAA+ ATPase p97/VCP functions as an essential mediator of ubiquitin-dependent cellular processes, extracting ubiquitylated proteins from macromolecular complexes or membranes by catalyzing their unfolding. p97 is directed to ub
Externí odkaz:
https://doaj.org/article/94acc0facb2c40838b11f84474d25e74
Autor:
Camilla S. Colding-Christensen, Ellen S. Kakulidis, Javier Arroyo-Gomez, Ivo A. Hendriks, Connor Arkinson, Zita Fábián, Agnieszka Gambus, Niels Mailand, Julien P. Duxin, Michael L. Nielsen
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Ubiquitin widely modifies proteins, thereby regulating most cellular functions. The complexity of ubiquitin signalling necessitates unbiased methods enabling global detection of dynamic protein ubiquitylation. Here, we describe UBIMAX (UBiqu
Externí odkaz:
https://doaj.org/article/c45c5dfb98ea4d949da491f277c33fef
Autor:
Laura J. Grange, John J. Reynolds, Farid Ullah, Bertrand Isidor, Robert F. Shearer, Xenia Latypova, Ryan M. Baxley, Antony W. Oliver, Anil Ganesh, Sophie L. Cooke, Satpal S. Jhujh, Gavin S. McNee, Robert Hollingworth, Martin R. Higgs, Toyoaki Natsume, Tahir Khan, Gabriel Á. Martos-Moreno, Sharon Chupp, Christopher G. Mathew, David Parry, Michael A. Simpson, Nahid Nahavandi, Zafer Yüksel, Mojgan Drasdo, Anja Kron, Petra Vogt, Annemarie Jonasson, Saad Ahmed Seth, Claudia Gonzaga-Jauregui, Karlla W. Brigatti, Alexander P. A. Stegmann, Masato Kanemaki, Dragana Josifova, Yuri Uchiyama, Yukiko Oh, Akira Morimoto, Hitoshi Osaka, Zineb Ammous, Jesús Argente, Naomichi Matsumoto, Constance T.R.M. Stumpel, Alexander M. R. Taylor, Andrew P. Jackson, Anja-Katrin Bielinsky, Niels Mailand, Cedric Le Caignec, Erica E. Davis, Grant S. Stewart
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-22 (2022)
The SMC5/6 complex is critical for genome stability. Here, the authors identify mutations in SLF2 and SMC5 as cause of Atelís Syndrome characterized by microcephaly, short stature, anemia, segmented chromosomes and mosaic variegated hyperploidy.
Externí odkaz:
https://doaj.org/article/bfe3845b80824c5996d10d21e1575e9d
Autor:
Marina E. Borisova, Andrea Voigt, Maxim A. X. Tollenaere, Sanjeeb Kumar Sahu, Thomas Juretschke, Nastasja Kreim, Niels Mailand, Chunaram Choudhary, Simon Bekker-Jensen, Masato Akutsu, Sebastian A. Wagner, Petra Beli
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
UV-light-induced DNA damage affects RNA metabolism but the underlying signalling pathways are largely unexplored. Here, the authors show that UV light triggers p38-MK2-mediated phosphorylation of the NELF complex, promoting its release from chromatin
Externí odkaz:
https://doaj.org/article/1c38a6be3fea435e8a20721ee3302833
Publikováno v:
eLife, Vol 8 (2019)
The faithful segregation of eukaryotic chromosomes in mitosis requires that the genome be duplicated completely prior to anaphase. However, cells with large genomes sometimes fail to complete replication during interphase and instead enter mitosis wi
Externí odkaz:
https://doaj.org/article/7a4bbbba579a45c4a2b6bfe82441f165
Autor:
Maxim A.X. Tollenaere, Christopher Tiedje, Simon Rasmussen, Julie C. Nielsen, Anna C. Vind, Melanie Blasius, Tanveer S. Batth, Niels Mailand, Jesper V. Olsen, Matthias Gaestel, Simon Bekker-Jensen
Publikováno v:
Cell Reports, Vol 26, Iss 13, Pp 3511-3521.e4 (2019)
Summary: Inflammatory signaling is restricted through degradation and the translational repression of cytokine mRNAs. A key factor in this regulation is tristetraprolin (TTP), an RNA-binding protein (RBP) that recruits RNA-destabilizing factors and t
Externí odkaz:
https://doaj.org/article/5588f8057b1148499dbf19a354bfd526
Autor:
Rune Busk Damgaard, Berthe Katrine Fiil, Carsten Speckmann, Monica Yabal, Udo zur Stadt, Simon Bekker‐Jensen, Philipp J. Jost, Stephan Ehl, Niels Mailand, Mads Gyrd‐Hansen
Publikováno v:
EMBO Molecular Medicine, Vol 5, Iss 8, Pp 1278-1295 (2013)
Abstract X‐linked Inhibitor of Apoptosis (XIAP) is an essential ubiquitin ligase for pro‐inflammatory signalling downstream of the nucleotide‐binding oligomerization domain containing (NOD)‐1 and ‐2 pattern recognition receptors. Mutations
Externí odkaz:
https://doaj.org/article/c4c84a4ab8224c50af75cc1e1e683af9
Autor:
Niels, Mailand
Publikováno v:
Molecular Cell. 83:3-5
In this issue of Molecular Cell, Yaneva et al.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10f01de27eb560feb46074e8a8729ae9
https://doi.org/10.1016/j.molcel.2022.12.009
https://doi.org/10.1016/j.molcel.2022.12.009
Autor:
Camilla S. Colding-Christensen, Ellen S. Kakulidis, Javier Arroyo-Gomez, Ivo A. Hendriks, Connor Arkinson, Zita Fábián, Agnieszka Gambus, Niels Mailand, Julien P. Duxin, Michael L. Nielsen
Ubiquitin widely modifies proteins, thereby regulating most cellular functions. The complexity of ubiquitin signalling necessitates unbiased methods enabling global detection of dynamic protein ubiquitylation. Here, we describe UBIMAX (UBiquitin targ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b13890b5da4774cae5b948c4358d1c02
https://doi.org/10.1101/2023.05.15.540799
https://doi.org/10.1101/2023.05.15.540799
Autor:
Esperanza Hernández-Carralero, Elisa Cabrera, Gara Rodríguez-Torres, Yeray Hernández-Reyes, Abhay N Singh, Cristina Santa-María, José Miguel Fernández-Justel, Roel C Janssens, Jurgen A Marteijn, Bernd O Evert, Niels Mailand, María Gómez, Kristijan Ramadan, Veronique A J Smits, Raimundo Freire
Publikováno v:
Hernández-Carralero, E, Cabrera, E, Rodríguez-Torres, G, Hernández-Reyes, Y, Singh, A N, Santa-María, C, Fernández-Justel, J M, Janssens, R C, Marteijn, J A, Evert, B O, Mailand, N, Gómez, M, Ramadan, K, Smits, V A J & Freire, R 2023, ' ATXN3 controls DNA replication and transcription by regulating chromatin structure ', Nucleic Acids Research, vol. 51, no. 11, pp. 5396–5413 . https://doi.org/10.1093/nar/gkad212
The deubiquitinating enzyme Ataxin-3 (ATXN3) contains a polyglutamine (PolyQ) region, the expansion of which causes spinocerebellar ataxia type-3 (SCA3). ATXN3 has multiple functions, such as regulating transcription or controlling genomic stability
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5aa7d5c4a33687a0e2797bef5f2c754
https://doi.org/10.1093/nar/gkad212
https://doi.org/10.1093/nar/gkad212